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Questions and Answers
What type of bond links monosaccharides to form oligosaccharides and polysaccharides?
What type of bond links monosaccharides to form oligosaccharides and polysaccharides?
Galactose is a pentose monosaccharide.
Galactose is a pentose monosaccharide.
False
What are the two types of glycosidic links mentioned in the content?
What are the two types of glycosidic links mentioned in the content?
N-glycosidic link and O-glycosidic link
Lactose is formed by the glycosidic bond between C 1 of β-galactose and C 4 of ________.
Lactose is formed by the glycosidic bond between C 1 of β-galactose and C 4 of ________.
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Match the following oligosaccharides with their components:
Match the following oligosaccharides with their components:
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Which enzyme hydrolyzes glycosidic bonds?
Which enzyme hydrolyzes glycosidic bonds?
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Oligosaccharides are formed from more than ten monosaccharide units.
Oligosaccharides are formed from more than ten monosaccharide units.
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Name one important disaccharide that has been listed.
Name one important disaccharide that has been listed.
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Which of the following statements is true regarding sucrose?
Which of the following statements is true regarding sucrose?
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Polysaccharides can consist of fewer than ten monosaccharide units.
Polysaccharides can consist of fewer than ten monosaccharide units.
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Name two common storage polysaccharides.
Name two common storage polysaccharides.
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Sucrose can be hydrolyzed into _______ and _______ by acids or the enzyme sucrase.
Sucrose can be hydrolyzed into _______ and _______ by acids or the enzyme sucrase.
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Match the following polysaccharides with their primary functions:
Match the following polysaccharides with their primary functions:
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What are heteropolysaccharides primarily composed of?
What are heteropolysaccharides primarily composed of?
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D-fructose is the most common monosaccharide in polysaccharides.
D-fructose is the most common monosaccharide in polysaccharides.
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Polysaccharides differ according to chain length and ________ of the monosaccharide units.
Polysaccharides differ according to chain length and ________ of the monosaccharide units.
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What type of polysaccharide is starch considered to be?
What type of polysaccharide is starch considered to be?
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Glycogen has fewer branches than amylopectin.
Glycogen has fewer branches than amylopectin.
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Name one structural polysaccharide mentioned in the content.
Name one structural polysaccharide mentioned in the content.
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Starch consists of two types: amylose and __________.
Starch consists of two types: amylose and __________.
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Match the following polysaccharides with their key features:
Match the following polysaccharides with their key features:
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What property is shared by all glycosaminoglycans (GAGs)?
What property is shared by all glycosaminoglycans (GAGs)?
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Hyaluronic acid is a type of glycosaminoglycan.
Hyaluronic acid is a type of glycosaminoglycan.
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Glycogen is especially abundant in the liver and __________.
Glycogen is especially abundant in the liver and __________.
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Which of the following is a homo-disaccharide?
Which of the following is a homo-disaccharide?
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Sucrose is classified as a reducing sugar.
Sucrose is classified as a reducing sugar.
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What are the monosaccharide units that make up lactose?
What are the monosaccharide units that make up lactose?
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Maltose consists of two units of __________.
Maltose consists of two units of __________.
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Match the disaccharides with their sources:
Match the disaccharides with their sources:
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Which type of bond links the monosaccharides in sucrose?
Which type of bond links the monosaccharides in sucrose?
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Both lactose and maltose have a free anomeric carbon and are thus reducing sugars.
Both lactose and maltose have a free anomeric carbon and are thus reducing sugars.
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What is the main enzyme that hydrolyzes lactose in the intestine?
What is the main enzyme that hydrolyzes lactose in the intestine?
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Which of the following is NOT a characteristic of Hyaluronic Acid (HA)?
Which of the following is NOT a characteristic of Hyaluronic Acid (HA)?
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Hyaluronic Acid is involved in wound healing.
Hyaluronic Acid is involved in wound healing.
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What occurs to the vitreous humor of the eye as age advances?
What occurs to the vitreous humor of the eye as age advances?
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Chondroitin sulfates are most abundant in ______, tendons, ligaments, and aorta.
Chondroitin sulfates are most abundant in ______, tendons, ligaments, and aorta.
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Which of the following is a function of hyaluronate lyase produced by some bacteria?
Which of the following is a function of hyaluronate lyase produced by some bacteria?
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Match the type of glycosaminoglycans (GAGs) with their occurrence:
Match the type of glycosaminoglycans (GAGs) with their occurrence:
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Dermatan sulfate contains a disaccharide unit of N-acetylgalactosamine and L-iduronic acid.
Dermatan sulfate contains a disaccharide unit of N-acetylgalactosamine and L-iduronic acid.
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What is one consequence of reduced hyaluronic acid levels in aging skin?
What is one consequence of reduced hyaluronic acid levels in aging skin?
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What is the primary function of heparin?
What is the primary function of heparin?
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All glycosaminoglycans are covalently attached to a core protein forming glycoproteins.
All glycosaminoglycans are covalently attached to a core protein forming glycoproteins.
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Name two tissues where keratan sulfate can be found.
Name two tissues where keratan sulfate can be found.
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The structure of proteoglycans involves a glycosidic bond between xylose and the hydroxyl group of __________.
The structure of proteoglycans involves a glycosidic bond between xylose and the hydroxyl group of __________.
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Which of the following is NOT a property of glycoproteins?
Which of the following is NOT a property of glycoproteins?
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Match the following components with their function:
Match the following components with their function:
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Hyaluronic acid is a glycosaminoglycan that is not attached to a core protein.
Hyaluronic acid is a glycosaminoglycan that is not attached to a core protein.
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What is the disaccharide unit found in keratan sulfate?
What is the disaccharide unit found in keratan sulfate?
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Study Notes
Carbohydrate II
- Intended Learning Outcomes (ILOs)
- Describe glycosidic linkage
- Define oligosaccharides and polysaccharides
- Understand nomenclature, structure, and properties of disaccharides and polysaccharides
- Classify disaccharides and polysaccharides
- List important disaccharides (e.g., maltose, lactose, and sucrose)
- Distinguish between polysaccharides and their derivatives; glycosaminoglycans, proteoglycans, and glycoproteins
Glycosidic Linkage
- Monosaccharides are joined by glycosidic bonds to form oligosaccharides and polysaccharides
- Glycosidic bonds are formed by enzymes called glycosyltransferases
- Glycosidic bonds are hydrolyzed to produce two monosaccharide molecules by enzymes called glycosidases
- Glycosidic bonds are named according to the carbon atoms involved in the bond
- Example: Lactose is synthesized by forming a β(1→4) glycosidic bond between C1 of β-galactose and C4 of glucose.
Oligosaccharides
- Oligosaccharides are molecules formed from a few (3-10) different monosaccharide units, including hexoses (e.g., glucose, fructose, mannose, and galactose) and pentoses (e.g., ribose and xylose)
- Disaccharides are the simplest oligosaccharides, consisting of two monosaccharide units linked by a glycosidic bond
- Classification of disaccharides: homo-disaccharides (e.g., maltose, isomaltose, cellobiose, and trehalose) consist of two similar monosaccharide units, and hetero-disaccharides (e.g., sucrose, lactose) consist of two different monosaccharide units
Nomenclature and Reducing Characteristics
- Anomeric carbon is present in the ring form of the sugar and represents the sugar carbonyl carbon responsible for reducing properties
- In many disaccharides (e.g., lactose and maltose), the anomeric carbon of one unit monosaccharide is involved in the glycosidic linkage, while the other is free
- Lactose and maltose are reducing sugars since one unit may have an open-chain form with an aldehyde group
- Sucrose is a non-reducing sugar because neither of the two rings is capable of opening
Disaccharides: Examples
- Lactose (milk sugar): β-D-galactose and α-D-glucose linked by β-1,4-galactosidic linkage; reducing sugar
- Maltose (malt sugar): two D-glucose residues linked by α-1,4-glucosidic bond; reducing sugar
- Sucrose (cane sugar, table sugar): β-D-fructose and α-D-glucose linked by α-1,2-glucosidic linkage; non-reducing sugar
Polysaccharides (Glycans)
- Polysaccharides are sugars that contain tens to thousands of monosaccharide units joined by glycosidic bonds to form linear chains or branched structures
- Polysaccharides differ according to chain length and branching and the type of the constituting monosaccharide units
- Starch: a glucose homopolymer, major storage polysaccharide in plants; consists of amylose (unbranched) and amylopectin (branched)
- Glycogen: a glucose homopolymer, main storage polysaccharide in animals; more extensively branched than amylopectin
- Polysaccharide Functions:
- Storage as energy reserves (e.g., starch, glycogen).
- Structural components (e.g., chitin, cellulose in plants)
- Cell membrane structure (e.g., mucopolysaccharides).
- Cellular recognition and communication.
Heteropolysaccharides (Glycosaminoglycans - GAGs)
- GAGs are linear chains of repeating disaccharide units
- Contain hexose, hexosamine, or hexuronic acid
- Often negatively charged due to sulfate residues (except hyaluronic acid)
- Important components of the extracellular matrix (ECM)
- Hyaluronic acid: not sulfated, found in synovial fluid, vitreous humor, and connective tissue.
- Chondroitin sulfates: most abundant GAGs in cartilage, tendons, and ligaments.
- Dermatan sulfate: found in skin, blood vessels, and heart valves
- Heparin/Heparan sulfate: anticoagulant, found in mast cells lining blood vessels.
- Keratan sulfate: found in cornea, cartilage, and bone.
Proteoglycans
- Proteoglycans are a subclass of glycoproteins
- They consist of glycosaminoglycans (GAGs) covalently attached to a core protein
- GAGs and core protein are linked together through a trihexoside (gala-gala-xyl) and a serine residue
Glycoproteins
- Glycoproteins are proteins containing short carbohydrate chains (usually oligosaccharides)
- Carbohydrate chains are linked to proteins by O-glycosidic and N-glycosidic bonds
- Important functions include cell-cell communication, blood group determination, and interactions with other molecules
Extracellular Matrix (ECM)
- A component of connective tissue
- Composed of proteoglycans and fibrous proteins (collagen, elastin, fibronectin, and laminin)
- Provides structural support, regulates cell behavior, facilitates nutrient diffusion.
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Description
Test your knowledge on oligosaccharides and polysaccharides, including the types of bonds that link monosaccharides, key enzymes involved, and important examples like lactose and sucrose. Explore the composition and function of various oligosaccharides and polysaccharides in this informative quiz.