Ocular Adrenergic Agonist and Antagonist Drugs Review

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27 Questions

Which neurotransmitter is involved in the efferent oculosympathetic pathway at the 1st order neuron trajectory?

Acetylcholine

What is the primary clinical use of 10% phenylephrine?

Posterior synechiae

Which direct sympathomimetic is structurally similar to epinephrine?

Phenylephrine

What is the effect of epinephrine on conjunctival vasoconstriction?

Conjunctival vasoconstriction

Which side effect is associated with topical epinephrine use?

Allergic dermatitis

What is the mechanism of action of 2.5% and 10% phenylephrine in clinical use?

Pupillary dilation

What is the primary neurotransmitter involved in the efferent oculosympathetic pathway at the 3rd order neuron trajectory?

Norepinephrine

Which side effect is associated with chronic use of phenylephrine?

Hypoxia of conjunctiva and iris

What are the systemic side effects associated with phenylephrine use?

Hypertension, tachycardia, subarachnoid hemorrhage

What clinical condition contraindicates the use of epinephrine in patients?

Narrow angles

What is the neurotransmitter in the sympathetic post-ganglionic synapse?

Norepinephrine

Which receptor type is involved in Ocular Autonomic Nervous System post-ganglionic structure?

Alpha (α) 1 receptors

What is the function of Iris Sphincter in the pupil?

Constriction via parasympathetic innervation

Which synapse in the sympathetic system has three components?

Post-ganglionic-organ effector synapse

In the Ocular Autonomic Nervous System, what neurotransmitter is present in some post-ganglionic sites?

Acetylcholine

Which nervous system regulates voluntary actions?

Somatic nervous system

What is the primary neurotransmitter in the central and pre-ganglionic synapse of the sympathetic system?

Acetylcholine

Which part of the eye dilates the pupil via sympathetic innervation?

Iris Dilator

Which drug interaction enhances the cardiovascular effect of tricyclic antidepressants and MAO inhibitors?

Guanethedine

What is the mode of action of 1% concentration paredrine?

Liberates norepinephrine from the pre-synaptic vesicle at the neuromuscular junction

What differentiates between central /2nd and 3rd neuron in Horner’s Syndrome?

Force duction test

What does a postcocaine anisocoria value of 0.8 mm indicate?

Horner's syndrome

What is the primary mode of action of Aproclonidine (Iopidine 0.5%)?

Decreases aqueous humor production

What is the mode of action of Brimonidine tartrate (Alphagan P 0.2%)?

Decreases aqueous production

What is the effect of Dapiprazole (Mydriolytic agent) on mydriasis?

Reversibly blocks ά-receptors on dilator muscle

Which ophthalmic beta blocker has a new mode of therapy with a maximum effect in 3 weeks?

Timolol Maleate (Timoptic)

'Rev-eyes 0.5%' is associated with which side effect?

Superficial punctate keratitis

Test your knowledge of ocular adrenergic agonist and antagonist drugs, as well as the nervous system related to the eye. This quiz covers topics such as efferent innervation, sympathetic and parasympathetic systems, and the autonomic nervous system.

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