NSAIDs: Therapeutic Uses and Side Effects

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What is the primary mechanism by which Aspirin-like drugs exert their analgesic, antipyretic, and anti-inflammatory effects?

Inhibition of Peripheral Prostaglandins synthesis (correct)

Stimulation of Prostaglandin synthesis

Activation of Lipoxygenase pathway

Inhibition of COX-3 enzyme

Which of the following is a potential side effect of Aspirin-like drugs in susceptible patients?

Bradycardia

Tachycardia

Bronchospasm (correct)

Hypotension

What is the primary reason why Aspirin-like drugs should be discontinued before labor in pregnant women?

To prevent Prolongation of Labor

To prevent Postpartum Hemorrhage

To prevent Intrauterine Closure of Ductus Arteriosus

All of the above (correct)

Why are NSAIDs not recommended in the first three months of pregnancy?

Risk of Birth Malformations Signup and view all the answers

What is the primary mechanism by which Paracetamol exerts its analgesic and antipyretic effects?

Selective inhibition of COX-3 enzyme Signup and view all the answers

What is the potential consequence of NSAIDs binding to plasma proteins in patients taking other medications?

Displacement of other drugs, leading to serious drug interactions Signup and view all the answers

Which of the following is NOT a therapeutic use of NSAIDs?

Treating bronchospasm Signup and view all the answers

What is the main concern with using NSAIDs in patients with renal disease?

Decreased renal blood flow and glomerular filtration Signup and view all the answers

Which of the following drugs is the safest analgesic and antipyretic in pregnant women?

Paracetamol Signup and view all the answers

What is the potential consequence of NSAIDs binding to plasma proteins in patients taking warfarin?

Displacement of warfarin from plasma proteins Signup and view all the answers

Why should Aspirin be discontinued before labor in pregnant women?

All of the above Signup and view all the answers

What is the primary reason why NSAIDs are not recommended in the last two weeks of pregnancy?

Risk of premature closure of the ductus arteriosus Signup and view all the answers

Why may NSAIDs induce bronchospasm in susceptible patients?

Due to increase in leukotriens, the product of the lipoxygenase pathway Signup and view all the answers

Why are NSAIDs not recommended during the last two weeks of pregnancy?

Due to the risk of bleeding Signup and view all the answers

What is the primary mechanism by which NSAIDs affect platelet function?

Through inhibition of the cyclooxygenase pathway Signup and view all the answers

What is the potential consequence of NSAIDs binding to plasma proteins in patients taking oral hypoglycemics?

Displacement of oral hypoglycemics, leading to serious drug interactions Signup and view all the answers

What is the therapeutic use of NSAIDs in patent ductus arteriosus?

To induce closure of the ductus arteriosus Signup and view all the answers

Why are NSAIDs not recommended in the first three months of pregnancy?

Due to the risk of birth malformations Signup and view all the answers

What is the primary mechanism by which NSAIDs decrease renal blood flow and glomerular filtration rate in patients with renal disease?

By reducing the synthesis of peripheral prostaglandins Signup and view all the answers

What is the primary reason why NSAIDs can cause salt and water retention?

Because they inhibit the production of prostaglandins Signup and view all the answers

What is the primary therapeutic use of NSAIDs in premature labor?

To relax the uterus Signup and view all the answers

What is the primary mechanism by which NSAIDs can cause gastric or intestinal ulcerations?

By inhibiting the production of prostaglandins Signup and view all the answers

What is the primary reason why NSAIDs can cause bleeding in pregnant women?

Because they reduce platelet function Signup and view all the answers

What is the primary therapeutic use of NSAIDs in patients with patent ductus arteriosus?

To close the patent ductus arteriosus Signup and view all the answers

What is the primary reason why Aspirin-like drugs can cause uterine contraction in pregnant women?

They inhibit the production of prostaglandins Signup and view all the answers

Why are NSAIDs not recommended in patients with renal disease?

They decrease renal blood flow and glomerular filtration rate Signup and view all the answers

What is the primary therapeutic use of Aspirin-like drugs in premature labor?

To relax the uterus Signup and view all the answers

Why may NSAIDs induce bronchospasm in susceptible patients?

They increase leukotriene production Signup and view all the answers

What is the primary concern with using NSAIDs in pregnant women during the last two weeks of pregnancy?

Postpartum hemorrhage Signup and view all the answers

What is the primary mechanism by which NSAIDs affect platelet function?

Inhibiting thromboxane production Signup and view all the answers

NSAIDs: Therapeutic Uses and Side Effects

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Questions and Answers

What is the primary mechanism by which Aspirin-like drugs exert their analgesic, antipyretic, and anti-inflammatory effects?

Which of the following is a potential side effect of Aspirin-like drugs in susceptible patients?

What is the primary reason why Aspirin-like drugs should be discontinued before labor in pregnant women?

Why are NSAIDs not recommended in the first three months of pregnancy?

What is the primary mechanism by which Paracetamol exerts its analgesic and antipyretic effects?

What is the potential consequence of NSAIDs binding to plasma proteins in patients taking other medications?

Which of the following is NOT a therapeutic use of NSAIDs?

What is the main concern with using NSAIDs in patients with renal disease?

Which of the following drugs is the safest analgesic and antipyretic in pregnant women?

What is the potential consequence of NSAIDs binding to plasma proteins in patients taking warfarin?

Why should Aspirin be discontinued before labor in pregnant women?

What is the primary reason why NSAIDs are not recommended in the last two weeks of pregnancy?

Why may NSAIDs induce bronchospasm in susceptible patients?

Why are NSAIDs not recommended during the last two weeks of pregnancy?

What is the primary mechanism by which NSAIDs affect platelet function?

What is the potential consequence of NSAIDs binding to plasma proteins in patients taking oral hypoglycemics?

What is the therapeutic use of NSAIDs in patent ductus arteriosus?

Why are NSAIDs not recommended in the first three months of pregnancy?

What is the primary mechanism by which NSAIDs decrease renal blood flow and glomerular filtration rate in patients with renal disease?

What is the primary reason why NSAIDs can cause salt and water retention?

What is the primary therapeutic use of NSAIDs in premature labor?

What is the primary mechanism by which NSAIDs can cause gastric or intestinal ulcerations?

What is the primary reason why NSAIDs can cause bleeding in pregnant women?

What is the primary therapeutic use of NSAIDs in patients with patent ductus arteriosus?

What is the primary reason why Aspirin-like drugs can cause uterine contraction in pregnant women?

Why are NSAIDs not recommended in patients with renal disease?

What is the primary therapeutic use of Aspirin-like drugs in premature labor?

Why may NSAIDs induce bronchospasm in susceptible patients?

What is the primary concern with using NSAIDs in pregnant women during the last two weeks of pregnancy?

What is the primary mechanism by which NSAIDs affect platelet function?

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