9 Questions
What is the essential characteristic of the acidic moiety in NSAIDs?
Strong organic acid with pKa in the 3.0–5.0 range
What property do NSAIDs differ in based on the lipophilic character of their aryl groups?
Lipophilicity
What range typically describes the pKa values of NSAIDs?
3.0–5.0
What is the major role of the acidic group in NSAIDs?
Serving as a binding group with plasma proteins
Which process leads to the inactivation of many NSAIDs?
Glucuronidation
What is a major pathway of clearance for many NSAIDs?
Glucuronidation followed by renal elimination
What is the mechanism of action for acetylsalicylic acid as an inhibitor of COX?
It irreversibly inhibits COX by transferring the acetyl group to a serine residue
What is the consequence of inhibiting the synthesis of thromboxane A by acetylsalicylic acid?
Reduction in platelet aggregation
Why are platelets unable to synthesize additional COX upon inhibition by acetylsalicylic acid?
Platelets lack a nucleus
Test your knowledge of NSAIDs chemical and pharmacologic properties with this quiz. Explore the structural and functional characteristics of NSAIDs, including their acidic nature and COX inhibitory activity.
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