10 Questions
What is the common chemical nucleus of sulfonamides?
Resembling P amino benzoic acid (PABA)
What is the pharmacokinetic feature of sulfonamides?
Modest tissue penetration
How do sulfonamides affect the solubility in acidic urine?
May be decreased, resulting in precipitation of metabolites
What is the selective toxicity of sulfonamides attributed to?
Inability of mammalian cells to synthesize folic acid
What type of organisms are sulfonamides active against?
Gram positive, gram negative, Chlamydia, and Nocardia
What route of administration is indicated for simple urinary tract infections?
Oral
Which condition is NOT indicated for topical administration of sulfonamides?
Fungal infections
What adverse reaction occurs commonly due to sulfonamides?
Nausea and diarrhea
Which drug interaction is associated with sulfonamides?
Competes with warfarin for plasma protein binding
What condition should be considered before using sulfonamides in the third trimester of pregnancy?
Risk of kernicterus in neonate
Test your knowledge on sulfonamides and their pharmacokinetic features including tissue penetration, metabolism, and excretion. Learn about the chemical structure, inhibition of dihydropteroate synthase, and solubility in acidic urine.
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