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Sulfonamides and Their Pharmacokinetics

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Questions and Answers

What is the common chemical nucleus of sulfonamides?

Resembling thiazide diuretics

Resembling P amino benzoic acid (PABA) (correct)

Resembling bilirubin

Resembling folic acid

What is the pharmacokinetic feature of sulfonamides?

Renal metabolism

Extensive tissue penetration

Excretion in feces

Modest tissue penetration (correct)

How do sulfonamides affect the solubility in acidic urine?

Become more soluble in acidic urine

Remain unaffected by urine pH

May be decreased, resulting in precipitation of metabolites (correct)

May be increased, leading to crystallization

What is the selective toxicity of sulfonamides attributed to?

Inability of mammalian cells to synthesize folic acid Signup and view all the answers

What type of organisms are sulfonamides active against?

Gram positive, gram negative, Chlamydia, and Nocardia Signup and view all the answers

What route of administration is indicated for simple urinary tract infections?

Oral Signup and view all the answers

Which condition is NOT indicated for topical administration of sulfonamides?

Fungal infections Signup and view all the answers

What adverse reaction occurs commonly due to sulfonamides?

Nausea and diarrhea Signup and view all the answers

Which drug interaction is associated with sulfonamides?

Competes with warfarin for plasma protein binding Signup and view all the answers

What condition should be considered before using sulfonamides in the third trimester of pregnancy?

Risk of kernicterus in neonate Signup and view all the answers