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Nitric Oxide Synthase (NOS) Structure and Function

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Nitric Oxide Synthase (NOS) Structure and Function

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Questions and Answers

What is the role of BH4 in NOS?

Coupling the reductase and oxygenase domains (correct)

Oxidizing the guanidine moiety of L-arginine

Transferring electrons from FMN to heme

Facilitating dimerization of the NOS monomers

What binds the substrate L-arginine and cofactor tetrahydrobiopterin (BH4) in NOS?

The reductase domain

Calmodulin

The oxygenase domain

Tetrahedral coordination of a zinc ion (correct)

What is the product of the reaction between the Fe2+-O2 complex and the guanidine moiety of L-arginine?

FMN and heme

L-arginine and BH4

NADPH and FAD

L-citrulline and NO (correct)

What is the purpose of the linker region in NOS?

Binding calmodulin Signup and view all the answers

What is the role of the zinc ion in the normal coupled state of NOS?

Stabilize the NOS dimer Signup and view all the answers

What is the net effect of the Fe3+ center of the heme being reduced to the ferrous (Fe2+) center?

The Fe2+-O2 complex reacts with molecular oxygen Signup and view all the answers

What is the consequence of BH4 scarcity on NOS?

NOS remains as a monomer and fails to bind L-arginine Signup and view all the answers

What is the byproduct of the uncoupled NOS reaction?

Superoxide (O2−) Signup and view all the answers

What is a major cause of NO deficiency in chronic disorders?

Deficiency of BH4 Signup and view all the answers

What is the result of BH4 deficiency on the body?

Tissue fibrosis and stiffening Signup and view all the answers