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Questions and Answers
What is the role of BH4 in NOS?
What is the role of BH4 in NOS?
- Coupling the reductase and oxygenase domains (correct)
- Oxidizing the guanidine moiety of L-arginine
- Transferring electrons from FMN to heme
- Facilitating dimerization of the NOS monomers
What binds the substrate L-arginine and cofactor tetrahydrobiopterin (BH4) in NOS?
What binds the substrate L-arginine and cofactor tetrahydrobiopterin (BH4) in NOS?
- The reductase domain
- Calmodulin
- The oxygenase domain
- Tetrahedral coordination of a zinc ion (correct)
What is the product of the reaction between the Fe2+-O2 complex and the guanidine moiety of L-arginine?
What is the product of the reaction between the Fe2+-O2 complex and the guanidine moiety of L-arginine?
- FMN and heme
- L-arginine and BH4
- NADPH and FAD
- L-citrulline and NO (correct)
What is the purpose of the linker region in NOS?
What is the purpose of the linker region in NOS?
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What is the role of the zinc ion in the normal coupled state of NOS?
What is the role of the zinc ion in the normal coupled state of NOS?
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What is the net effect of the Fe3+ center of the heme being reduced to the ferrous (Fe2+) center?
What is the net effect of the Fe3+ center of the heme being reduced to the ferrous (Fe2+) center?
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What is the consequence of BH4 scarcity on NOS?
What is the consequence of BH4 scarcity on NOS?
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What is the byproduct of the uncoupled NOS reaction?
What is the byproduct of the uncoupled NOS reaction?
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What is a major cause of NO deficiency in chronic disorders?
What is a major cause of NO deficiency in chronic disorders?
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What is the result of BH4 deficiency on the body?
What is the result of BH4 deficiency on the body?
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