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eNOS Function and Cardiovascular Health

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Questions and Answers

What is the outcome of eNOS uncoupling in endothelial cells?

Increased production of nitric oxide

Enhanced VSMC relaxation

Stimulation of angiogenesis

Production of strong oxidizing free radicals that damage cellular components (correct)

What is the effect of Rho-ROCK signaling on eNOS in endothelial cells?

Stimulation of eNOS expression and activity

Enhanced VSMC contraction

No effect on eNOS expression and activity

Inhibition of eNOS expression and activity (correct)

What is the role of eNOS in the vasodilation of blood vessels?

Production of nitric oxide, which stimulates VSMC relaxation (correct)

Regulation of blood vessel growth and development

Stimulation of VSMC contraction

Inhibition of VSMC relaxation

What is the effect of eNOS knockout on blood pressure?

Increased blood pressure Signup and view all the answers

What is the consequence of impaired NO pathways in humans?

Increased risk of atherosclerosis, diabetes, and hypertension Signup and view all the answers

What is determined by the barrier properties of the endothelium?

Microvascular permeability Signup and view all the answers

Which of the following is NOT an agent that increases microvascular permeability?

Nitric oxide Signup and view all the answers

What is the primary function of quiescent ECs?

To provide a barrier to solutes Signup and view all the answers

What is the function of endothelial cells in capillaries?

To form a selectively permeable barrier between the blood and tissues Signup and view all the answers

What is the process of forming new blood vessels from existing ones?

Angiogenesis Signup and view all the answers

What happens to endothelial cells upon tissue injury or in response to increased oxygen and nutrient demands?

They become proliferative and migratory, forming new blood vessels Signup and view all the answers

What does eNOS regulate in vascular barrier function?

Nitric oxide production Signup and view all the answers

What is the role of nitric oxide in regulating endothelial and vascular homeostasis?

It relaxes vascular smooth muscle cells, prevents platelet adhesion, and regulates inflammation Signup and view all the answers

What is unique about endothelial cells in terms of their structure and function?

They are organotypic, meaning their structure and function vary depending on the organ or tissue Signup and view all the answers

What is the enzyme responsible for producing nitric oxide in endothelial cells?

Endothelial nitric oxide synthase (eNOS) Signup and view all the answers