Podcast
Questions and Answers
What is the role of α1A-adrenoceptors stimulation in BPH?
What is the role of α1A-adrenoceptors stimulation in BPH?
- Increasing c-GMP levels
- Causing smooth muscle relaxation
- Enhancing tissue perfusion
- Increasing prostatic urethral resistance (correct)
What is the primary effect of PDE5 inhibitors in the treatment of erectile dysfunction?
What is the primary effect of PDE5 inhibitors in the treatment of erectile dysfunction?
- Inducing smooth muscle contraction
- Increasing heart rate
- Causing vasodilation (correct)
- Inhibiting muscle relaxation
How does PDE5 negatively impact BPH?
How does PDE5 negatively impact BPH?
- By hydrolyzing c-GMP to inactive GMP (correct)
- By activating Protein Kinase G
- By reducing free intracellular Ca2+ levels
- By elevating c-GMP levels
Which visual side effect is commonly associated with the use of PDE5 inhibitors?
Which visual side effect is commonly associated with the use of PDE5 inhibitors?
Why are PDE5 inhibitors contraindicated in patients using organic nitrates?
Why are PDE5 inhibitors contraindicated in patients using organic nitrates?
Which pathway, besides the α1A-adrenoceptors stimulation, is involved in smooth muscle contractility related to BPH?
Which pathway, besides the α1A-adrenoceptors stimulation, is involved in smooth muscle contractility related to BPH?
What is the main mechanism of action of PDE5 inhibitors in treating erectile dysfunction?
What is the main mechanism of action of PDE5 inhibitors in treating erectile dysfunction?
Where is the Phosphodiesterase 5 enzyme located in the urinary tract?
Where is the Phosphodiesterase 5 enzyme located in the urinary tract?
What effect does PDE5 inhibition have on smooth muscle in the detrusor musculature?
What effect does PDE5 inhibition have on smooth muscle in the detrusor musculature?
Which common side effect is NOT typically associated with the use of PDE5 inhibitors?
Which common side effect is NOT typically associated with the use of PDE5 inhibitors?
Which subtype of alpha-1-receptors prevail in the bladder neck?
Which subtype of alpha-1-receptors prevail in the bladder neck?
What happens when there is adrenergic stimulation of α1A-receptors in the bladder neck?
What happens when there is adrenergic stimulation of α1A-receptors in the bladder neck?
In what part of the urinary tract do α1DARs predominate?
In what part of the urinary tract do α1DARs predominate?
Which subtype of alpha-1-receptors predominates in the human vascular bed with aging?
Which subtype of alpha-1-receptors predominates in the human vascular bed with aging?
What effect does blocking α1DARs have on LUTS symptoms?
What effect does blocking α1DARs have on LUTS symptoms?
What enzyme converts testosterone into DHT?
What enzyme converts testosterone into DHT?
Which of the following is a condition associated with DHT?
Which of the following is a condition associated with DHT?
Where is Type II isoform of 5-Alpha Reductase primarily active?
Where is Type II isoform of 5-Alpha Reductase primarily active?
What effect does DHT have on the scalp?
What effect does DHT have on the scalp?
When should a 5-Alpha Reductase inhibitor be offered to men as per the information provided?
When should a 5-Alpha Reductase inhibitor be offered to men as per the information provided?
What is a common phenotype observed in individuals with 5-alpha reductase deficiency?
What is a common phenotype observed in individuals with 5-alpha reductase deficiency?
Which urinary condition can be effectively managed in men with overactive bladder (OAB) induced by BPH using selective β3 adrenergic receptor agonists?
Which urinary condition can be effectively managed in men with overactive bladder (OAB) induced by BPH using selective β3 adrenergic receptor agonists?
How does 5-alpha reductase deficiency typically affect male infants' external genitalia?
How does 5-alpha reductase deficiency typically affect male infants' external genitalia?
Which medication is used to prevent contraction of the detrusor muscle in the urinary bladder wall?
Which medication is used to prevent contraction of the detrusor muscle in the urinary bladder wall?
In individuals with 5-alpha reductase deficiency, what is a common characteristic of the urethra opening in male infants affected by the condition?
In individuals with 5-alpha reductase deficiency, what is a common characteristic of the urethra opening in male infants affected by the condition?
