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Questions and Answers
What physiological effect does excessive contraction of the ciliary muscle indicate?
What physiological effect does excessive contraction of the ciliary muscle indicate?
Which substance is primarily depleted by capsaicin in nerve endings to relieve pain?
Which substance is primarily depleted by capsaicin in nerve endings to relieve pain?
What is the primary function of the TRPV1 receptor?
What is the primary function of the TRPV1 receptor?
At what temperature does the TRPV1 receptor typically open?
At what temperature does the TRPV1 receptor typically open?
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Which type of surgery involves reshaping the refractive power of the eye?
Which type of surgery involves reshaping the refractive power of the eye?
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Why are birds unaffected by capsaicin?
Why are birds unaffected by capsaicin?
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Which of the following is responsible for the refractive power of the eye?
Which of the following is responsible for the refractive power of the eye?
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What happens to presynaptic Substance P during prolonged activation by capsaicin?
What happens to presynaptic Substance P during prolonged activation by capsaicin?
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What function do inner hair cells serve in the auditory system?
What function do inner hair cells serve in the auditory system?
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What role do outer hair cells play in relation to inner hair cells?
What role do outer hair cells play in relation to inner hair cells?
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How many outer hair cells are present compared to inner hair cells?
How many outer hair cells are present compared to inner hair cells?
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What part of the cochlea is primarily responsible for supporting the auditory signal's transduction?
What part of the cochlea is primarily responsible for supporting the auditory signal's transduction?
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What anatomical structure aids in decompression of acoustic energy in the cochlea?
What anatomical structure aids in decompression of acoustic energy in the cochlea?
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How do nerve fibers from the brain stem interact with outer hair cells?
How do nerve fibers from the brain stem interact with outer hair cells?
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What characteristic of the fibers in the basilar membrane changes from the base to the helicotrema?
What characteristic of the fibers in the basilar membrane changes from the base to the helicotrema?
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What characterizes Deutan Dichromat vision?
What characterizes Deutan Dichromat vision?
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Which condition involves green sensitivity shifted toward red?
Which condition involves green sensitivity shifted toward red?
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What kind of vibratory movement do the stiff fibers in the basilar membrane exhibit?
What kind of vibratory movement do the stiff fibers in the basilar membrane exhibit?
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What type of potential is used by most neural elements in the retina for signal transmission?
What type of potential is used by most neural elements in the retina for signal transmission?
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Which cell type in the retina has action potentials and sends signals to the brain?
Which cell type in the retina has action potentials and sends signals to the brain?
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What effect does lateral inhibition have on visual processing?
What effect does lateral inhibition have on visual processing?
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In Protan Dichromat vision, which type of cones are absent?
In Protan Dichromat vision, which type of cones are absent?
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Which of the following describes a Protanope?
Which of the following describes a Protanope?
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What is the primary function of horizontal cells in the retina?
What is the primary function of horizontal cells in the retina?
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What is the primary function of the dorsal column-medial lemniscal system?
What is the primary function of the dorsal column-medial lemniscal system?
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Where does the anterolateral system decussate?
Where does the anterolateral system decussate?
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What is a dermatome?
What is a dermatome?
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What characterizes the spatial orientation of the anterolateral system?
What characterizes the spatial orientation of the anterolateral system?
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Which area of the body has the most significant representation in the somatosensory cortex?
Which area of the body has the most significant representation in the somatosensory cortex?
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How does shingles typically manifest in relation to dermatomes?
How does shingles typically manifest in relation to dermatomes?
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What does the sensory homunculus represent?
What does the sensory homunculus represent?
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Which type of fibers are primarily found in the dorsal column-medial lemniscal system?
Which type of fibers are primarily found in the dorsal column-medial lemniscal system?
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What does the Place principle determine in relation to sound?
What does the Place principle determine in relation to sound?
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How is sound intensity expressed in terms of decibels?
How is sound intensity expressed in terms of decibels?
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What factors contribute to the pathophysiology of noise-induced hearing loss?
What factors contribute to the pathophysiology of noise-induced hearing loss?
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What is the significance of a 1-decibel increase in sound intensity?
What is the significance of a 1-decibel increase in sound intensity?
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Which sound level corresponds to a normal conversation in decibels?
Which sound level corresponds to a normal conversation in decibels?
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What indicates the maximum safe exposure duration for sounds at 90 dB?
What indicates the maximum safe exposure duration for sounds at 90 dB?
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What sound level is associated with the quietest sound that humans can hear?
What sound level is associated with the quietest sound that humans can hear?
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What occurs when a shotgun blast is heard in terms of hearing protection?
What occurs when a shotgun blast is heard in terms of hearing protection?
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Study Notes
Sensory Pathways Overview
- Sensory information enters the spinal cord through dorsal roots of spinal nerves.
- Two main pathways exist for sensory afferents: the Anterolateral system and the Dorsal column-medial lemniscal system.
Dorsal Column-Medial Lemniscal System
- Comprises large myelinated nerve fibers (30-110 m/sec), specifically A-beta fibers.
- Utilizes three neurons to transmit signals to the sensory cortex and decussates in the medulla oblongata.
- Maintains a high degree of spatial orientation, allowing rapid transmission of mechanoreceptor information, including touch and vibration.
Anterolateral System
- Contains smaller myelinated and unmyelinated fibers for slower transmission (0.5-40 m/sec), including A-delta and C fibers.
- Also uses three neurons to reach the sensory cortex but decussates in the spinal cord.
- Features a lower degree of spatial orientation, capable of transmitting varied modalities such as pain, thermal sensations, crude touch, and pressure.
Dermatomes
- Defined as skin areas supplied by sensory neurons from a spinal nerve ganglion.
- Clinically significant for localizing spinal cord lesions and identifying areas affected by viruses such as varicella zoster.
- Hosts referred pain, where pain is perceived in a location different from its source.
Shingles and Dermatome Connection
- Following a chickenpox infection, varicella zoster virus may reactivate, causing a rash in the affected nerve's dermatome.
Somatosensory Cortex
- Located in the postcentral gyrus, exhibiting a highly organized spatial orientation.
- Each cortex side receives sensory information from the opposite body side.
- Displays unequal body representation, with the lips having the greatest area, followed by the face and thumb; the trunk has the least representation.
Sensory Homunculus
- Represents the proportional space allocated to different parts of the body in the somatosensory cortex.
Brodmann’s Areas
- Demonstrates cytoarchitectural organization of neurons in the cerebral cortex, recognized through Nissl stain.
Substance P and Capsaicin
- Substance P plays a role in mediating lower back pain, arthritis, and fibromyalgia.
- Capsaicin, derived from chili peppers, can reduce pain by depleting Substance P from nerve endings, providing pain relief through selective binding to the TRPV1 receptor.
Phyiscal Anatomy of the Eye
- White outer layer is continuous with the cornea at the front; suspensory fibers connect the ciliary muscle to the lens.
- Contains transparent, jellylike tissue with photosensitive cells and 2/3 of the eye’s refractive power.
- Vision correction procedures like LASEK/LASIK reshape this component for improved visual acuity.
Color Perception
- Understanding of deuteranomaly, dichromatism, and protanomalous vision, with associated sensitivities and prevalence statistics among males.
Retinal Organization and Signal Transmission
- Processing begins in the retina using electrotonic potentials for signal transmission.
- Ganglion cells send action potentials to the brain through the optic nerve, responding to light intensity changes and enhancing image contrast through lateral inhibition.
Auditory Signal Processing
- Inner hair cells transmit auditory signals, while outer hair cells modulate sensitivity to different pitches.
- The cochlea’s basilar membrane contains fibers whose stiffness varies by frequency, enabling the perception of pitch.
Sound Frequency and Amplitude
- The place principle describes how different sound frequencies stimulate specific basilar membrane locations.
- Sound intensity is expressed in decibels, reflecting the logarithm of actual sound intensity, where 10-fold increases signify a bel.
Noise-Induced Hearing Loss
- Prevalent condition characterized by decreased stereocilia stiffness and loss caused by exposure to high decibel levels.
- Recommendations for maximum sound exposure durations to prevent hearing damage based on decibel levels.
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