Neuromuscular Blockers and Skeletal Muscle Relaxants Quiz
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Questions and Answers

Which type of skeletal muscle relaxant interferes with transmission at the neuromuscular end plate?

  • Non-depolarizing (Competitive) blockers
  • Neuromuscular blockers (correct)
  • Spasmolytic Drugs
  • Centrally Acting Directly-Acting

    • Which drug is a prototype of non-depolarizing (competitive) blockers?

  • Atracurium
  • Pancuronium
  • Rocuronium
  • d-Tubocurarine (correct)

    • What is the order of paralysis caused by succinylcholine?

  • Face, trunk, respiratory, hyperkalemia, limbs, neck, jaws, eyes
  • Neck, respiratory, trunk, limbs, face, eyes, jaws, pharynx
  • Neck, limbs, face, jaws, eyes, pharynx, trunk, respiratory (correct)
  • Respiratory, hyperkalemia, malignant hyperthermia

    • How does succinylcholine affect the neuromuscular junction and autonomic ganglia?

    <p>More effect on NMJ and less on autonomic ganglia</p> Signup and view all the answers

    What is the mechanism of action of non-depolarizing (competitive) blockers?

    <p>Reversible competitive antagonists</p> Signup and view all the answers

    What is the main use of spasmolytic drugs?

    <p>To reduce spasticity in painful conditions</p> Signup and view all the answers

    What is the effect of depolarizing blockers on the end plate?

    <p>Block the end plate from responding to further stimulation</p> Signup and view all the answers

    What is the primary use of neuromuscular blockers?

    <p>For surgical procedures and tracheal intubation</p> Signup and view all the answers

    Which drug acts as a GABAB agonist and is used for severe spasticity in conditions like cerebral palsy and multiple sclerosis?

    <p>Baclofen</p> Signup and view all the answers

    Which drug facilitates GABAergic transmission in the central nervous system and is used for chronic spasm due to cerebral palsy and stroke?

    <p>Diazepam</p> Signup and view all the answers

    Which drug is an α2-Adrenoceptor agonist in the spinal cord and is used for spasm due to multiple sclerosis and stroke?

    <p>Tizanidine</p> Signup and view all the answers

    Which drug blocks RyR1 Ca2+ release channels in the sarcoplasmic reticulum of skeletal muscle and is used for spasm due to cerebral palsy, spinal cord injury, and multiple sclerosis?

    <p>Dantrolene</p> Signup and view all the answers

    Which neuromuscular blocking drug is 5 times more potent than d-tubocurarine and has a long onset time of 2.9 minutes?

    <p>Pancuronium</p> Signup and view all the answers

    Which neuromuscular blocking drug has a rapid onset time of 1 minute and a duration of action of 55 minutes?

    <p>Rocuronium</p> Signup and view all the answers

    Which neuromuscular blocking drug is good for patients with kidney and liver diseases and has a duration of action of 45 minutes?

    <p>Atracurium</p> Signup and view all the answers

    Which drug acts in the brain stem, possibly by interfering with polysynaptic reflexes that maintain skeletal muscle tone and has marked sedative and antimuscarinic actions?

    <p>Cyclobenzaprine</p> Signup and view all the answers

    What is the mechanism of action of Baclofen?

    <p>Facilitates GABAergic transmission in the central nervous system</p> Signup and view all the answers

    What is the main use of Atracurium?

    <p>Surgical relaxation</p> Signup and view all the answers

    What is the effect of hypokalemia on nondepolarizing blockers?

    <p>Potentiates their effects</p> Signup and view all the answers

    What is the mechanism of action of Dantrolene?

    <p>Blocks RyR1 Ca2+ release channels in the sarcoplasmic reticulum of skeletal muscle</p> Signup and view all the answers

    What are the adverse effects of Cyclobenzaprine?

    <p>Confusion, visual hallucinations</p> Signup and view all the answers

    What is the order of paralysis caused by nondepolarizing blockers?

    <p>Eyes, fingers, limbs, neck, face, trunk, respiratory</p> Signup and view all the answers

    What is the duration of action of Pancuronium?

    <p>110 minutes</p> Signup and view all the answers

    Which drug is a potentiation factor for nondepolarizing blockers?

    <p>Neostigmine</p> Signup and view all the answers

    What is the mechanism of action of Tizanidine?

    <p>Acts as an α2-Adrenoceptor agonist in the spinal cord</p> Signup and view all the answers

    What is the onset time of Mivacurium?

    <p>1.8 minutes</p> Signup and view all the answers

    Which drug is used for acute spasm due to muscle injury and inflammation?

    <p>Cyclobenzaprine</p> Signup and view all the answers

    What is the primary use of Rocuronium?

    <p>Tracheal intubation</p> Signup and view all the answers

    What is the primary use of neuromuscular blockers?

    <p>Induction of general anesthesia and tracheal intubation</p> Signup and view all the answers

    What is the mechanism of action of succinylcholine?

    <p>Causes desensitization of Ach receptors</p> Signup and view all the answers

    Which drug is a prototype of depolarizing blockers?

    <p>Succinylcholine</p> Signup and view all the answers

    What is the order of paralysis caused by succinylcholine?

    <p>Neck → limbs → face → jaws → eyes → pharynx → trunk → respiratory</p> Signup and view all the answers

    What is the primary use of spasmolytic drugs?

    <p>Reduction of spasticity in painful conditions</p> Signup and view all the answers

    Which drug is used for acute muscle spasm due to injury and inflammation?

    <p>Cyclobenzaprine</p> Signup and view all the answers

    What is the mechanism of action of non-depolarizing (competitive) blockers?

    <p>Reversible competitive antagonists</p> Signup and view all the answers

    What is the main use of Atracurium?

    <p>Muscle relaxation during surgical procedures</p> Signup and view all the answers

    What is the effect of hypokalemia on nondepolarizing blockers?

    <p>Prolongs the block</p> Signup and view all the answers

    Which drug is used for chronic spasm due to cerebral palsy and stroke?

    <p>Tizanidine</p> Signup and view all the answers

    What is the duration of action of Pancuronium?

    <p>60 minutes</p> Signup and view all the answers

    Which drug is a potentiation factor for nondepolarizing blockers?

    <p>Dantrolene</p> Signup and view all the answers

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