40 Questions
Which type of skeletal muscle relaxant interferes with transmission at the neuromuscular end plate?
Neuromuscular blockers
Which drug is a prototype of non-depolarizing (competitive) blockers?
d-Tubocurarine
What is the order of paralysis caused by succinylcholine?
Neck, limbs, face, jaws, eyes, pharynx, trunk, respiratory
How does succinylcholine affect the neuromuscular junction and autonomic ganglia?
More effect on NMJ and less on autonomic ganglia
What is the mechanism of action of non-depolarizing (competitive) blockers?
Reversible competitive antagonists
What is the main use of spasmolytic drugs?
To reduce spasticity in painful conditions
What is the effect of depolarizing blockers on the end plate?
Block the end plate from responding to further stimulation
What is the primary use of neuromuscular blockers?
For surgical procedures and tracheal intubation
Which drug acts as a GABAB agonist and is used for severe spasticity in conditions like cerebral palsy and multiple sclerosis?
Baclofen
Which drug facilitates GABAergic transmission in the central nervous system and is used for chronic spasm due to cerebral palsy and stroke?
Diazepam
Which drug is an α2-Adrenoceptor agonist in the spinal cord and is used for spasm due to multiple sclerosis and stroke?
Tizanidine
Which drug blocks RyR1 Ca2+ release channels in the sarcoplasmic reticulum of skeletal muscle and is used for spasm due to cerebral palsy, spinal cord injury, and multiple sclerosis?
Dantrolene
Which neuromuscular blocking drug is 5 times more potent than d-tubocurarine and has a long onset time of 2.9 minutes?
Pancuronium
Which neuromuscular blocking drug has a rapid onset time of 1 minute and a duration of action of 55 minutes?
Rocuronium
Which neuromuscular blocking drug is good for patients with kidney and liver diseases and has a duration of action of 45 minutes?
Atracurium
Which drug acts in the brain stem, possibly by interfering with polysynaptic reflexes that maintain skeletal muscle tone and has marked sedative and antimuscarinic actions?
Cyclobenzaprine
What is the mechanism of action of Baclofen?
Facilitates GABAergic transmission in the central nervous system
What is the main use of Atracurium?
Surgical relaxation
What is the effect of hypokalemia on nondepolarizing blockers?
Potentiates their effects
What is the mechanism of action of Dantrolene?
Blocks RyR1 Ca2+ release channels in the sarcoplasmic reticulum of skeletal muscle
What are the adverse effects of Cyclobenzaprine?
Confusion, visual hallucinations
What is the order of paralysis caused by nondepolarizing blockers?
Eyes, fingers, limbs, neck, face, trunk, respiratory
What is the duration of action of Pancuronium?
110 minutes
Which drug is a potentiation factor for nondepolarizing blockers?
Neostigmine
What is the mechanism of action of Tizanidine?
Acts as an α2-Adrenoceptor agonist in the spinal cord
What is the onset time of Mivacurium?
1.8 minutes
Which drug is used for acute spasm due to muscle injury and inflammation?
Cyclobenzaprine
What is the primary use of Rocuronium?
Tracheal intubation
What is the primary use of neuromuscular blockers?
Induction of general anesthesia and tracheal intubation
What is the mechanism of action of succinylcholine?
Causes desensitization of Ach receptors
Which drug is a prototype of depolarizing blockers?
Succinylcholine
What is the order of paralysis caused by succinylcholine?
Neck → limbs → face → jaws → eyes → pharynx → trunk → respiratory
What is the primary use of spasmolytic drugs?
Reduction of spasticity in painful conditions
Which drug is used for acute muscle spasm due to injury and inflammation?
Cyclobenzaprine
What is the mechanism of action of non-depolarizing (competitive) blockers?
Reversible competitive antagonists
What is the main use of Atracurium?
Muscle relaxation during surgical procedures
What is the effect of hypokalemia on nondepolarizing blockers?
Prolongs the block
Which drug is used for chronic spasm due to cerebral palsy and stroke?
Tizanidine
What is the duration of action of Pancuronium?
60 minutes
Which drug is a potentiation factor for nondepolarizing blockers?
Dantrolene
Test your knowledge of neuromuscular blockers and skeletal muscle relaxants with this quiz. Learn about the different types of skeletal muscle relaxants, including neuromuscular blockers such as non-depolarizing and depolarizing blockers, as well as spasmolytic drugs. Explore drugs used for acute muscle spasm and enhance your understanding of these essential pharmacological concepts.
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