12 Questions
What is the primary mechanism by which iodinated contrast causes acute kidney injury (AKI)?
Intense renal vasoconstriction
Which of the following pharmacologic interventions has been shown to reduce the incidence of contrast-associated AKI?
None of the above
Which of the following is a key, preventable risk factor for AKI?
Volume depletion
Which of the following nephrotoxins is commonly encountered in the perioperative setting?
all correct
What is the recommended approach to prevent AKI when using nephrotoxic medications?
Avoid combinations of nephrotoxins when possible
Which of the following is a conventional indication for renal replacement therapy (dialysis)?
Acidosis
What is the optimal timing for initiating dialysis in critically ill and postoperative patients with AKI?
Initiation for stage 2 AKI (doubling of sCr or decreased urine output)
What is a key modifiable risk factor for acute kidney injury (AKI) associated with contrast use?
Volume depletion
Which antibiotic combination has been linked to an increased rate of AKI?
vancomycin and piperacillin-tazobactam
What is a common nephrotoxin encountered in the perioperative setting other than aminoglycosides?
NSAIDs
What is a conventional indication for initiating renal replacement therapy (dialysis)?
Uremia
When considering the optimal timing for dialysis initiation after cardiac surgery, what stage of AKI showed significant benefit from early initiation?
Stage 2 AKI
Test your knowledge on nephrotoxins and acute kidney injury. Explore the association between iodinated contrast and renal vasoconstriction, pharmacologic interventions, and key risk factors for contrast-associated AKI. Learn about other common nephrotoxins encountered in the perioperative setting.
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