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Nephrotoxicity and Hepatotoxicity Quiz
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Nephrotoxicity and Hepatotoxicity Quiz

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Questions and Answers

What is the potential consequence of progressive concentration of toxicants along the nephron?

  • Increased glomerular filtration rate
  • Decreased tubular obstruction
  • Renal calculus formation (correct)
  • Enhanced urine concentrating ability
  • How do activation reactions in the kidney contribute to nephrotoxicity susceptibility?

  • They decrease the reabsorption of glucose in the proximal tubule
  • They enhance glomerular filtration rate
  • They reduce the risk of hepatotoxicity
  • They activate toxic metabolites that can lead to kidney damage (correct)
  • Which of the following toxicants can be activated in both the liver and kidney?

  • Vitamin C
  • Magnesium oxide
  • Acetaminophen (correct)
  • Calcium carbonate
  • What role does ADH play in urine concentration?

    <p>It impairs urine concentrating ability</p> Signup and view all the answers

    Which type of proteinuria indicates glomerular damage?

    <p>Albuminuria</p> Signup and view all the answers

    What can chemically induced increases in urine volume accompanied by decreases in osmolality suggest?

    <p>Defect in ADH synthesis, release, and/or action</p> Signup and view all the answers

    How does Glucosuria reflect defects in renal function?

    <p>It represents failures in proximal tubular sugar reabsorption</p> Signup and view all the answers

    Which condition might result from chemically induced changes causing increased urine volume and decreased osmolality?

    <p>Impaired urine concentration ability</p> Signup and view all the answers

    What could chemically induced changes in urinary composition possibly suggest?

    <p>Defective proximal tubular reabsorption mechanisms</p> Signup and view all the answers

    How does the accumulation and metabolism of xenobiotics contribute to kidney susceptibility to toxic injury?

    <p>It increases the risk of kidney damage from toxicants</p> Signup and view all the answers

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