Nazmun Nahar Alam Tetracycline Quiz
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Questions and Answers

What is the effect of Tetracycline when given to pregnant women?

  • Reduces the effect of ADH
  • Gets deposited in the bones of the foetus (correct)
  • Causes hepatotoxicity
  • Increases intestinal flora

    • Which tetracycline drug antagonizes ADH in the nephron?

  • Minocycline
  • Demeclocycline (correct)
  • Doxycycline
  • Tigecycline

    • What is a common side effect associated with Minocycline?

  • Hepatotoxicity
  • Intestinal bleeding
  • Vestibular toxicity (correct)
  • Renal failure

    • Which tetracycline is considered the drug of choice for most indications?

    <p>Doxycycline</p> Signup and view all the answers

    What is a contraindication for using Tetracycline?

    <p>Pregnant &amp; lactating mothers</p> Signup and view all the answers

    What reduces the absorption of tetracycline by chelation?

    <p>Iron</p> Signup and view all the answers

    In which condition is Tigecycline effective?

    <p>Infections due to tetracycline-resistant gram-positive organisms</p> Signup and view all the answers

    What distinguishes Doxycycline from other tetracyclines in terms of absorption?

    <p>Completely absorbed in GI and less affected by food intake</p> Signup and view all the answers

    What is the classification of tetracyclines based on plasma half-life?

    <p>Short-acting, intermediate-acting, long-acting</p> Signup and view all the answers

    Which tetracycline falls under the short-acting category based on plasma half-life?

    <p>Oxytetracycline</p> Signup and view all the answers

    What is the mechanism of action of tetracyclines?

    <p>Blocking the binding of aminoacyl-tRNA to the acceptor site on the mRNA ribosome complex</p> Signup and view all the answers

    What type of bacteria are tetracyclines effective against?

    <p>Both Gram-positive and Gram-negative bacteria</p> Signup and view all the answers

    What is the primary route of excretion for most tetracyclines?

    <p>Urinary excretion</p> Signup and view all the answers

    Which of the following is true about tetracycline resistance?

    <p>It is a common phenomenon in both Gram-positive and Gram-negative bacteria</p> Signup and view all the answers

    Which tetracycline can be given to patients with kidney dysfunction due to its excretion via bile?

    <p>Doxycycline</p> Signup and view all the answers

    What is the main pharmacokinetic consideration for taking tetracyclines?

    <p>Should be taken with water while standing to avoid oesophageal ulcers</p> Signup and view all the answers

    What effect does administration with milk or antacids have on the oral absorption of demeclocycline?

    <p>Incomplete &amp; impaired due to complex formation</p> Signup and view all the answers

    Which adverse effect of tetracyclines specifically affects pregnant women?

    <p>Hepatotoxicity</p> Signup and view all the answers

    'Methacycline' falls under which category based on plasma half-life?

    <p>Intermediate-acting</p> Signup and view all the answers

    What is the indication for tetracyclines in combination therapy?

    <p>Peptic ulcer disease (H.Pylori)</p> Signup and view all the answers

    What is the characteristic feature of 'Doxycycline' regarding oral absorption and dosing frequency?

    <p>Completely absorbed, long half-life, OD or BD dosing</p> Signup and view all the answers

    Why should tetracyclines not be given to children below 8 years?

    <p>They get deposited in teeth causing yellow discoloration &amp; increased susceptibility to caries</p> Signup and view all the answers

    Which type of infection is NOT an indication for tetracyclines?

    <p>(Pelvic inflammatory disease)</p> Signup and view all the answers

    What is a key characteristic of Tetracycline antibiotics?

    <p>Broad spectrum of activity</p> Signup and view all the answers

    Which of the following is NOT a Tetracycline antibiotic?

    <p>Ciprofloxacin</p> Signup and view all the answers

    What type of antibiotic is Tetracycline in terms of its bactericidal properties?

    <p>Bacteriostatic</p> Signup and view all the answers

    Which of the following is NOT a mechanism of resistance to Tetracyclines?

    <p>Increased drug uptake</p> Signup and view all the answers

    Among the listed options, which antibiotic has a similar spectrum of activity to Tetracyclines?

    <p>Azithromycin</p> Signup and view all the answers

    Which statement accurately describes the pharmacokinetics of Tetracyclines?

    <p>They are extensively metabolized in the liver.</p> Signup and view all the answers

    What is the classification of demeclocycline, minocycline, and doxycycline among Tetracycline antibiotics?

    <p>Second-generation Tetracyclines</p> Signup and view all the answers

    Which of the following is a mechanism of action shared by demeclocycline, minocycline, and doxycycline?

    <p>Inhibition of protein synthesis</p> Signup and view all the answers

    'Ribosomal protection proteins' are involved in which resistance mechanism against Tetracycline antibiotics?

    <p>'Alterations in ribosomal target site'</p> Signup and view all the answers

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