Nazmun Nahar Alam Tetracycline Quiz

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What is the effect of Tetracycline when given to pregnant women?

Reduces the effect of ADH

Gets deposited in the bones of the foetus (correct)

Causes hepatotoxicity

Increases intestinal flora

Which tetracycline drug antagonizes ADH in the nephron?

Minocycline

Demeclocycline (correct)

Doxycycline

Tigecycline

What is a common side effect associated with Minocycline?

Hepatotoxicity

Intestinal bleeding

Vestibular toxicity (correct)

Renal failure

Which tetracycline is considered the drug of choice for most indications?

Doxycycline Signup and view all the answers

What is a contraindication for using Tetracycline?

Pregnant & lactating mothers Signup and view all the answers

What reduces the absorption of tetracycline by chelation?

Iron Signup and view all the answers

In which condition is Tigecycline effective?

Infections due to tetracycline-resistant gram-positive organisms Signup and view all the answers

What distinguishes Doxycycline from other tetracyclines in terms of absorption?

Completely absorbed in GI and less affected by food intake Signup and view all the answers

What is the classification of tetracyclines based on plasma half-life?

Short-acting, intermediate-acting, long-acting Signup and view all the answers

Which tetracycline falls under the short-acting category based on plasma half-life?

Oxytetracycline Signup and view all the answers

What is the mechanism of action of tetracyclines?

Blocking the binding of aminoacyl-tRNA to the acceptor site on the mRNA ribosome complex Signup and view all the answers

What type of bacteria are tetracyclines effective against?

Both Gram-positive and Gram-negative bacteria Signup and view all the answers

What is the primary route of excretion for most tetracyclines?

Urinary excretion Signup and view all the answers

Which of the following is true about tetracycline resistance?

It is a common phenomenon in both Gram-positive and Gram-negative bacteria Signup and view all the answers

Which tetracycline can be given to patients with kidney dysfunction due to its excretion via bile?

Doxycycline Signup and view all the answers

What is the main pharmacokinetic consideration for taking tetracyclines?

Should be taken with water while standing to avoid oesophageal ulcers Signup and view all the answers

What effect does administration with milk or antacids have on the oral absorption of demeclocycline?

Incomplete & impaired due to complex formation Signup and view all the answers

Which adverse effect of tetracyclines specifically affects pregnant women?

Hepatotoxicity Signup and view all the answers

'Methacycline' falls under which category based on plasma half-life?

Intermediate-acting Signup and view all the answers

What is the indication for tetracyclines in combination therapy?

Peptic ulcer disease (H.Pylori) Signup and view all the answers

What is the characteristic feature of 'Doxycycline' regarding oral absorption and dosing frequency?

Completely absorbed, long half-life, OD or BD dosing Signup and view all the answers

Why should tetracyclines not be given to children below 8 years?

They get deposited in teeth causing yellow discoloration & increased susceptibility to caries Signup and view all the answers

Which type of infection is NOT an indication for tetracyclines?

(Pelvic inflammatory disease) Signup and view all the answers

What is a key characteristic of Tetracycline antibiotics?

Broad spectrum of activity Signup and view all the answers

Which of the following is NOT a Tetracycline antibiotic?

Ciprofloxacin Signup and view all the answers

What type of antibiotic is Tetracycline in terms of its bactericidal properties?

Bacteriostatic Signup and view all the answers

Which of the following is NOT a mechanism of resistance to Tetracyclines?

Increased drug uptake Signup and view all the answers

Among the listed options, which antibiotic has a similar spectrum of activity to Tetracyclines?

Azithromycin Signup and view all the answers

Which statement accurately describes the pharmacokinetics of Tetracyclines?

They are extensively metabolized in the liver. Signup and view all the answers

What is the classification of demeclocycline, minocycline, and doxycycline among Tetracycline antibiotics?

Second-generation Tetracyclines Signup and view all the answers

Which of the following is a mechanism of action shared by demeclocycline, minocycline, and doxycycline?

Inhibition of protein synthesis Signup and view all the answers

'Ribosomal protection proteins' are involved in which resistance mechanism against Tetracycline antibiotics?

'Alterations in ribosomal target site' Signup and view all the answers