Nazmun Nahar Alam Tetracycline Quiz
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Questions and Answers

What is the effect of Tetracycline when given to pregnant women?

  • Reduces the effect of ADH
  • Gets deposited in the bones of the foetus (correct)
  • Causes hepatotoxicity
  • Increases intestinal flora

Which tetracycline drug antagonizes ADH in the nephron?

  • Minocycline
  • Demeclocycline (correct)
  • Doxycycline
  • Tigecycline

What is a common side effect associated with Minocycline?

  • Hepatotoxicity
  • Intestinal bleeding
  • Vestibular toxicity (correct)
  • Renal failure

Which tetracycline is considered the drug of choice for most indications?

<p>Doxycycline (C)</p> Signup and view all the answers

What is a contraindication for using Tetracycline?

<p>Pregnant &amp; lactating mothers (D)</p> Signup and view all the answers

What reduces the absorption of tetracycline by chelation?

<p>Iron (A)</p> Signup and view all the answers

In which condition is Tigecycline effective?

<p>Infections due to tetracycline-resistant gram-positive organisms (C)</p> Signup and view all the answers

What distinguishes Doxycycline from other tetracyclines in terms of absorption?

<p>Completely absorbed in GI and less affected by food intake (B)</p> Signup and view all the answers

What is the classification of tetracyclines based on plasma half-life?

<p>Short-acting, intermediate-acting, long-acting (B)</p> Signup and view all the answers

Which tetracycline falls under the short-acting category based on plasma half-life?

<p>Oxytetracycline (C)</p> Signup and view all the answers

What is the mechanism of action of tetracyclines?

<p>Blocking the binding of aminoacyl-tRNA to the acceptor site on the mRNA ribosome complex (A)</p> Signup and view all the answers

What type of bacteria are tetracyclines effective against?

<p>Both Gram-positive and Gram-negative bacteria (C)</p> Signup and view all the answers

What is the primary route of excretion for most tetracyclines?

<p>Urinary excretion (B)</p> Signup and view all the answers

Which of the following is true about tetracycline resistance?

<p>It is a common phenomenon in both Gram-positive and Gram-negative bacteria (B)</p> Signup and view all the answers

Which tetracycline can be given to patients with kidney dysfunction due to its excretion via bile?

<p>Doxycycline (B)</p> Signup and view all the answers

What is the main pharmacokinetic consideration for taking tetracyclines?

<p>Should be taken with water while standing to avoid oesophageal ulcers (D)</p> Signup and view all the answers

What effect does administration with milk or antacids have on the oral absorption of demeclocycline?

<p>Incomplete &amp; impaired due to complex formation (B)</p> Signup and view all the answers

Which adverse effect of tetracyclines specifically affects pregnant women?

<p>Hepatotoxicity (A)</p> Signup and view all the answers

'Methacycline' falls under which category based on plasma half-life?

<p>Intermediate-acting (D)</p> Signup and view all the answers

What is the indication for tetracyclines in combination therapy?

<p>Peptic ulcer disease (H.Pylori) (C)</p> Signup and view all the answers

What is the characteristic feature of 'Doxycycline' regarding oral absorption and dosing frequency?

<p>Completely absorbed, long half-life, OD or BD dosing (D)</p> Signup and view all the answers

Why should tetracyclines not be given to children below 8 years?

<p>They get deposited in teeth causing yellow discoloration &amp; increased susceptibility to caries (B)</p> Signup and view all the answers

Which type of infection is NOT an indication for tetracyclines?

<p>(Pelvic inflammatory disease) (C)</p> Signup and view all the answers

What is a key characteristic of Tetracycline antibiotics?

<p>Broad spectrum of activity (A)</p> Signup and view all the answers

Which of the following is NOT a Tetracycline antibiotic?

<p>Ciprofloxacin (D)</p> Signup and view all the answers

What type of antibiotic is Tetracycline in terms of its bactericidal properties?

<p>Bacteriostatic (A)</p> Signup and view all the answers

Which of the following is NOT a mechanism of resistance to Tetracyclines?

<p>Increased drug uptake (B)</p> Signup and view all the answers

Among the listed options, which antibiotic has a similar spectrum of activity to Tetracyclines?

<p>Azithromycin (D)</p> Signup and view all the answers

Which statement accurately describes the pharmacokinetics of Tetracyclines?

<p>They are extensively metabolized in the liver. (D)</p> Signup and view all the answers

What is the classification of demeclocycline, minocycline, and doxycycline among Tetracycline antibiotics?

<p>Second-generation Tetracyclines (A)</p> Signup and view all the answers

Which of the following is a mechanism of action shared by demeclocycline, minocycline, and doxycycline?

<p>Inhibition of protein synthesis (B)</p> Signup and view all the answers

'Ribosomal protection proteins' are involved in which resistance mechanism against Tetracycline antibiotics?

<p>'Alterations in ribosomal target site' (D)</p> Signup and view all the answers

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