Antibiotics Inhibiting Protein Synthesis Quiz
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Questions and Answers

Which antibiotic binds reversibly to the 30S subunit, blocking the binding of tRNA to the acceptor site on the mRNA-ribosome complex?

  • Aminoglycosides
  • Streptogramins
  • Tetracyclines (correct)
  • Macrolides

    • What is the chemical structure of tetracyclines?

  • octahydronaphthacene ring as a scaffold (correct)
  • streptidine moiety
  • aminoglycoside moiety
  • macrocyclic lactone ring structure

    • How does resistance to tetracyclines develop?

  • Preventing accumulation of the drug inside the bacterial cell (correct)
  • Increasing influx of the drug into the bacterial cell
  • Decreasing efflux of the drug from the bacterial cell
  • Enhancing bacterial ribosome function

    • What type of activity do tetracyclines exhibit?

    <p>Broad spectrum of activity (Gram + and Gram -, protozoa, ricketsie)</p> Signup and view all the answers

    Which region of the tetracycline structure carries out chelation of divalent atoms by c11 and c12 oxygen atoms?

    <p>Metal ion binding region</p> Signup and view all the answers

    What predominates at physiological pH in the structure of tetracycline?

    <p>Zwitterionic tetracycline</p> Signup and view all the answers

    Which modification makes the drug more water soluble and prone to hydrolysis in vivo?

    <p>Aminoalkylation of N</p> Signup and view all the answers

    What renders the drug inactive or produces toxic products due to a photochemical reaction?

    <p>Metal ion binding face modification</p> Signup and view all the answers

    What is the impact of the presence of 5-OH on the drug?

    <p>Affects pharmacokinetics but not activity</p> Signup and view all the answers

    What is the effect of the removal of the tertiary amine substituent on the drug's activity?

    <p>Reduces activity</p> Signup and view all the answers

    Which generation of tetracycline is more stable to acidic pH due to the absence of C6-OH?

    <p>3rd generation</p> Signup and view all the answers

    What is the role of Mannich reaction in tetracycline derivatives?

    <p>Increases water solubility and hydrolysis in vivo</p> Signup and view all the answers

    What characteristic is associated with semisynthetic tetracyclines analogues such as doxycycline and minocycline?

    <p>Oral administration</p> Signup and view all the answers

    What are tetracycline derivatives like Rolitetracycline and Mepicycline known for?

    <p>Low toxicity but high G.I side effects</p> Signup and view all the answers

    What is the impact of adding small alkyl groups to tetracycline?

    <p>Reduces activity</p> Signup and view all the answers

    What is the role of aminoalkylation of the amide nitrogen in tetracycline derivatives?

    <p>Increases water solubility and hydrolysis in vivo</p> Signup and view all the answers

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