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Questions and Answers
Which antibiotic binds reversibly to the 30S subunit, blocking the binding of tRNA to the acceptor site on the mRNA-ribosome complex?
Which antibiotic binds reversibly to the 30S subunit, blocking the binding of tRNA to the acceptor site on the mRNA-ribosome complex?
- Aminoglycosides
- Streptogramins
- Tetracyclines (correct)
- Macrolides
What is the chemical structure of tetracyclines?
What is the chemical structure of tetracyclines?
- octahydronaphthacene ring as a scaffold (correct)
- streptidine moiety
- aminoglycoside moiety
- macrocyclic lactone ring structure
How does resistance to tetracyclines develop?
How does resistance to tetracyclines develop?
- Preventing accumulation of the drug inside the bacterial cell (correct)
- Increasing influx of the drug into the bacterial cell
- Decreasing efflux of the drug from the bacterial cell
- Enhancing bacterial ribosome function
What type of activity do tetracyclines exhibit?
What type of activity do tetracyclines exhibit?
Which region of the tetracycline structure carries out chelation of divalent atoms by c11 and c12 oxygen atoms?
Which region of the tetracycline structure carries out chelation of divalent atoms by c11 and c12 oxygen atoms?
What predominates at physiological pH in the structure of tetracycline?
What predominates at physiological pH in the structure of tetracycline?
Which modification makes the drug more water soluble and prone to hydrolysis in vivo?
Which modification makes the drug more water soluble and prone to hydrolysis in vivo?
What renders the drug inactive or produces toxic products due to a photochemical reaction?
What renders the drug inactive or produces toxic products due to a photochemical reaction?
What is the impact of the presence of 5-OH on the drug?
What is the impact of the presence of 5-OH on the drug?
What is the effect of the removal of the tertiary amine substituent on the drug's activity?
What is the effect of the removal of the tertiary amine substituent on the drug's activity?
Which generation of tetracycline is more stable to acidic pH due to the absence of C6-OH?
Which generation of tetracycline is more stable to acidic pH due to the absence of C6-OH?
What is the role of Mannich reaction in tetracycline derivatives?
What is the role of Mannich reaction in tetracycline derivatives?
What characteristic is associated with semisynthetic tetracyclines analogues such as doxycycline and minocycline?
What characteristic is associated with semisynthetic tetracyclines analogues such as doxycycline and minocycline?
What are tetracycline derivatives like Rolitetracycline and Mepicycline known for?
What are tetracycline derivatives like Rolitetracycline and Mepicycline known for?
What is the impact of adding small alkyl groups to tetracycline?
What is the impact of adding small alkyl groups to tetracycline?
What is the role of aminoalkylation of the amide nitrogen in tetracycline derivatives?
What is the role of aminoalkylation of the amide nitrogen in tetracycline derivatives?
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