40 Questions
What is a characteristic of sedation caused by morphine?
Indifference to surroundings and own body
What is the effect of morphine on the respiratory centre?
Depression of respiratory centre in a dose-dependent manner
What is the cause of death in morphine poisoning?
Respiratory failure
What is the effect of morphine on the mental state of patients in pain or anxiety?
It produces a feeling of pleasure
Which of the following centers is more sensitive to morphine than the respiratory centre?
Cough centre
What is the effect of morphine on the vasomotor centre?
It is depressed at higher doses
What is the effect of morphine on the CNS?
It depresses the CNS
What is the cause of nausea and vomiting as side effects of morphine?
Stimulation of the CTZ
What is the effect of morphine on a healthy individual?
It does not produce cognizable respiratory depression
What is the effect of morphine on the heart rate?
It decreases the heart rate
What is the effect of morphine on the cardiovascular system?
It has no effect on the cardiovascular system
What is the effect of morphine on the release of ACTH?
It decreases the release of ACTH
What is the effect of morphine on the gastrointestinal system?
It has no effect on the gastrointestinal system
What is the cause of miosis caused by morphine?
Stimulation of the Edinger Westphal nucleus
What is the effect of morphine on the release of GH?
It increases the release of GH
What is the effect of morphine on the body temperature?
It decreases the body temperature
What is the primary mechanism by which morphine causes vasodilation?
Release of histamine
Which of the following is NOT a consequence of morphine's effect on the cardiovascular system?
Increased cardiac work
What is the primary cause of constipation in patients taking morphine?
Increased tone and segmentation of the intestines
Which of the following is a common endocrine effect of morphine?
Impotence and menstrual irregularities
What is the effect of morphine on ADH release?
It increases ADH release
Which of the following is a CNS effect of morphine?
Central sympathetic stimulation
What is the effect of morphine on cardiac work?
It decreases cardiac work
Which of the following is a consequence of morphine's effect on the respiratory system?
Increased CO2 retention
What is the primary site of action for morphine's analgesic effects?
μ opioid receptor in the Central Nervous System
What type of alkaloids does opium contain?
Both Phenanthrene and Benzoisoquinoline derivatives
What is the primary effect of morphine on the biliary tract?
Spasm of sphincter of Oddi
What is the percentage of morphine in opium?
10% in opium
Why can morphine be dangerous in asthmatics?
It releases histamine, leading to bronchoconstriction
Which of the following is a semisynthetic opioid?
Diacetylmorphine
What is the effect of morphine on the perception of pain?
It alters the perception of pain, making it less unpleasant or distressing
What is the effect of morphine on urinary bladder tone?
Increased tone of both detrusor and sphincter
What is the primary action of morphine on the Central Nervous System?
Site-specific depressant and stimulant actions
What is the primary reason for the unreliable oral absorption of morphine?
High and variable first pass metabolism
Which type of pain is relieved better by morphine?
Dull, poorly localized visceral pain
How long does the effect of a parenteral dose of morphine typically last?
4-6 hours
What is the primary mechanism of morphine elimination?
Glucuronide conjugation
What is the effect of increasing the dose of morphine on analgesia?
The degree of analgesia increases
Why does morphine freely cross the placenta?
It is highly lipophilic
Why does morphine remain chronically constipating?
No tolerance develops to its central action
This quiz covers the pharmacological actions of morphine on the central nervous system, including its effects on the cough centre, temperature regulating centre, and vasomotor centre.
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