10 Questions
What is the main consideration when choosing an animal for polyclonal antibody production?
Foreignness of the antigen to the animal
Which of the following is a consideration when selecting an animal for antibody production?
Genomic differences between animals of the same species
What type of animal is typically used for monoclonal antibody production?
Mouse
Why is it important to consider convenience when choosing an animal for antibody production?
To ensure the animal is easy to buy and maintain
What is the typical size of animals used for polyclonal antibody production?
Large
What is the significance of using an animal with a different genome for polyclonal antibody production?
To increase the chances of producing antibodies
Why is it important to consider foreignness when selecting an animal for antibody production?
To ensure the antigen is recognized by the animal's immune system
What is the main difference between monoclonal and polyclonal antibody production in terms of the animal used?
The type of animal used
Why is it important to use the same strain of animal for polyclonal antibody production?
To minimize genetic variations
What is the benefit of using a large animal for polyclonal antibody production?
It produces a higher yield of antibodies
Study Notes
Monoclonal and Polyclonal Antibodies
- Monoclonal antibodies are typically produced in mice.
- Polyclonal antibodies are typically produced in larger animals, such as rabbits, goats, or sheep.
Choosing the Right Animal for Antibody Production
- The antigen should be foreign to the animal to ensure an effective immune response.
- Consider convenience factors, such as ease of purchase, care, and space requirements.
- Choose an animal with a consistent genome, as even animals of the same species can have slightly different genomes; use the same strain of animal for optimal results.
Monoclonal and Polyclonal Antibodies
- Monoclonal antibodies are typically produced in mice.
- Polyclonal antibodies are typically produced in larger animals, such as rabbits, goats, or sheep.
Choosing the Right Animal for Antibody Production
- The antigen should be foreign to the animal to ensure an effective immune response.
- Consider convenience factors, such as ease of purchase, care, and space requirements.
- Choose an animal with a consistent genome, as even animals of the same species can have slightly different genomes; use the same strain of animal for optimal results.
Learn about the differences between monoclonal and polyclonal antibodies, and the factors to consider when choosing an animal for antibody production.
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