Podcast
Questions and Answers
What is the preferred treatment for B. Fragilis infections?
What is the preferred treatment for B. Fragilis infections?
Which Pseudomonas species is predominantly found in clinical settings?
Which Pseudomonas species is predominantly found in clinical settings?
Which type of infections is commonly associated with P. aeruginosa?
Which type of infections is commonly associated with P. aeruginosa?
What is a characteristic property of Pseudomonas species?
What is a characteristic property of Pseudomonas species?
Signup and view all the answers
What type of infections can commonly lead to sepsis caused by Pseudomonas?
What type of infections can commonly lead to sepsis caused by Pseudomonas?
Signup and view all the answers
What kind of organisms are common in the human colon that are resistant to antibiotics?
What kind of organisms are common in the human colon that are resistant to antibiotics?
Signup and view all the answers
In which patients is P. aeruginosa most commonly associated with wound infections?
In which patients is P. aeruginosa most commonly associated with wound infections?
Signup and view all the answers
What environmental conditions do Pseudomonas species thrive in?
What environmental conditions do Pseudomonas species thrive in?
Signup and view all the answers
What is a significant clinical outcome of systemic Pseudomonas infections?
What is a significant clinical outcome of systemic Pseudomonas infections?
Signup and view all the answers
Which type of pneumonia is associated with Legionella pneumophila?
Which type of pneumonia is associated with Legionella pneumophila?
Signup and view all the answers
What is the main virulence factor of Legionella pneumophila?
What is the main virulence factor of Legionella pneumophila?
Signup and view all the answers
How is Legionella pneumophila primarily acquired?
How is Legionella pneumophila primarily acquired?
Signup and view all the answers
Which group is typically more susceptible to Legionnaire's disease?
Which group is typically more susceptible to Legionnaire's disease?
Signup and view all the answers
Which of the following is a characteristic of Pontiac Fever?
Which of the following is a characteristic of Pontiac Fever?
Signup and view all the answers
Which diagnostic test is used for Legionnaire's disease?
Which diagnostic test is used for Legionnaire's disease?
Signup and view all the answers
What is Brucellosis also known as?
What is Brucellosis also known as?
Signup and view all the answers
What type of bacteria is Brucella classified as?
What type of bacteria is Brucella classified as?
Signup and view all the answers
Where do Brucella bacteria localize in the body?
Where do Brucella bacteria localize in the body?
Signup and view all the answers
What is a common risk factor for developing Legionnaire's disease?
What is a common risk factor for developing Legionnaire's disease?
Signup and view all the answers
What is the primary treatment for competent individuals with severe localized abscesses caused by Yersinia Pestis?
What is the primary treatment for competent individuals with severe localized abscesses caused by Yersinia Pestis?
Signup and view all the answers
Which virulence factor of Yersinia Pestis helps block phagocytosis?
Which virulence factor of Yersinia Pestis helps block phagocytosis?
Signup and view all the answers
What is the ID50 of Yersinia Pestis, making it particularly dangerous?
What is the ID50 of Yersinia Pestis, making it particularly dangerous?
Signup and view all the answers
How is Yersinia Pestis primarily transmitted from rodent hosts to humans?
How is Yersinia Pestis primarily transmitted from rodent hosts to humans?
Signup and view all the answers
What characteristic describes Bubonic plague in terms of its clinical findings?
What characteristic describes Bubonic plague in terms of its clinical findings?
Signup and view all the answers
Which factor contributes to the pathogenesis of Yersinia Pestis in its flea vector?
Which factor contributes to the pathogenesis of Yersinia Pestis in its flea vector?
Signup and view all the answers
What is a major clinical manifestation of Septicemic plague?
What is a major clinical manifestation of Septicemic plague?
Signup and view all the answers
Which factor does NOT contribute to Yersinia Pestis's ability to facilitate intracellular growth?
Which factor does NOT contribute to Yersinia Pestis's ability to facilitate intracellular growth?
Signup and view all the answers
What was the historical name for Septicemic plague during the 14th century in Europe?
What was the historical name for Septicemic plague during the 14th century in Europe?
Signup and view all the answers
What is a potential mode of transmission of pneumonic plague among humans?
What is a potential mode of transmission of pneumonic plague among humans?
Signup and view all the answers
What is the most common cause of atypical pneumonia?
What is the most common cause of atypical pneumonia?
Signup and view all the answers
Which of the following is NOT a symptom associated with atypical pneumonia?
Which of the following is NOT a symptom associated with atypical pneumonia?
Signup and view all the answers
Which complication is NOT typically associated with pneumonia?
Which complication is NOT typically associated with pneumonia?
Signup and view all the answers
What type of treatment can shorten the course of atypical pneumonia?
What type of treatment can shorten the course of atypical pneumonia?
Signup and view all the answers
What is a recognized symptom of Ureaplasma Urealyticum infection in women?
What is a recognized symptom of Ureaplasma Urealyticum infection in women?
Signup and view all the answers
How is M. Genitalium most commonly diagnosed?
How is M. Genitalium most commonly diagnosed?
Signup and view all the answers
Which drug combination is primarily recommended for treating dapsone-resistant infections?
Which drug combination is primarily recommended for treating dapsone-resistant infections?
Signup and view all the answers
What is a characteristic feature of Actinomyces israelii infections?
What is a characteristic feature of Actinomyces israelii infections?
Signup and view all the answers
Which characteristic is true for Mycoplasma pneumoniae?
Which characteristic is true for Mycoplasma pneumoniae?
Signup and view all the answers
Nocardia asteroides infections are primarily associated with which of the following sources?
Nocardia asteroides infections are primarily associated with which of the following sources?
Signup and view all the answers
Which of the following conditions can prolonged IUD retention lead to?
Which of the following conditions can prolonged IUD retention lead to?
Signup and view all the answers
What is the primary mode of transmission for Mycoplasma pneumoniae?
What is the primary mode of transmission for Mycoplasma pneumoniae?
Signup and view all the answers
What percentage of community-acquired pneumonia is caused by Mycoplasma pneumoniae, particularly among young adults?
What percentage of community-acquired pneumonia is caused by Mycoplasma pneumoniae, particularly among young adults?
Signup and view all the answers
What type of bacteria are actinomycetes classified as?
What type of bacteria are actinomycetes classified as?
Signup and view all the answers
Which feature distinguishes Mycoplasmas from other bacteria?
Which feature distinguishes Mycoplasmas from other bacteria?
Signup and view all the answers
Which condition is NOT caused by Mycoplasma pneumoniae?
Which condition is NOT caused by Mycoplasma pneumoniae?
Signup and view all the answers
Study Notes
Pseudomonas
- Most commonly encountered species is Pseudomonas aeruginosa.
- Found in soil, water, moist skin, and occasionally the colon.
- Causes various diseases associated with weakened immunity and low neutrophil counts.
- Pseudomonas aeruginosa is a major nosocomial pathogen.
- Pseudomonas aeruginosa is an obligate aerobe (oxidase-positive and non-fermenter of glucose, except for Pseudomonas aeruginosa), and can grow in plain water with minimal nutrition.
Legionella Pneumophila
- Intracellular parasites that can live in amoebas in nature and macrophages during infection.
- Anerobic; lipopolysaccharide is the main virulence factor.
- Found in areas where water collects and in soil; can become airborne in the wind or ventilation systems.
- Resistant to chlorine.
- Acquired by inhaling aerosols; not transmitted person-to-person (humans are dead-end hosts).
- Alveolar macrophages consume Legionella pneumophila for defense, but the bacteria then multiply within them.
Brucella (Brucellosis = undulant fever)
- Coccobacillus lacking a capsule.
- Aerobic; LPS is the main virulence factor.
- Intracellular in macrophages; localizes to the reticuloendothelial system (lymph nodes, liver, spleen, bone marrow = connective tissue macrophages).
Yersinia Pestis (Plague)
- Small rod-shaped bacteria with bipolar staining; intracellular.
- Extremely low infectious dose (1-10 organisms); potential bioweapon.
- Transmitted among rodents via fleas; humans are accidental hosts after being bitten by infected fleas.
- Two epidemiological cycles:
- Sylvatic cycle: Wild rodents (especially prairie dogs in the U.S.)
- Urban cycle: Rats in the city (not currently found in the U.S.)
- Respiratory droplet transmission can occur from patients with pneumonic plague.
- Forms a biofilm in the upper gastrointestinal tract of the flea, preventing nourishment; the starving blocked flea bites more hosts and regurgitates bacteria.
Actinomycetes
- Filamentous, resembling fungi.
- Gram-positive; some are weakly acid-fast.
Actinomyces Israeli
- Normal oral microbiota; invades after trauma or poor dental hygiene.
- Yellow "sulfur" granules (masses of filaments) in draining pus.
- 50% of cases occur in the face and neck; the remainder in the chest or abdomen.
- Prolonged retention of intrauterine devices (IUDs) can lead to pelvic actinomycosis.
Nocardia Asteroides
- Primarily found in soil; inhaled or enters through wounds.
- Can infect immunocompromised lungs, causing abscesses and pneumonia, and then disseminate.
Mycoplasmas
- Among the smallest bacteria known.
- Lack a cell wall; thus, cell wall-targeting antibiotics are ineffective.
- Can change shape.
- Do not stain with Gram stain.
- Cell membrane contains cholesterol, which stiffens it, as in eukaryotes.
- Cause problems in laboratory tissue cultures of eukaryotic cells.
- M.Pneumoniae is pathogenic only in humans.
M.Pneumoniae (Atypical Pneumonia)
- Transmitted by respiratory droplets.
- Has adhesions for ciliated bronchial epithelium.
- Produces an exotoxin similar to that of pertussis.
- Causes inflammation and necrosis; inhibits ciliary motion.
- Causes 10-20% of community-acquired pneumonia, especially among young adults in close quarters.
- More frequent in the fall and winter.
- Autoantibodies against red blood cells, brain, lung, and liver can form during infection.
Genital Mycoplasmas (Found in Urogenital Tract)
- M. Hominis causes postpartum fever and pelvic inflammatory disease.
- Ureaplasma urealyticum causes non-gonococcal urethritis. In women, it can cause endometritis and is associated with premature labor and delivery.
- M. Genitalium is sexually transmitted; causes non-gonococcal urethritis in men. In women, it causes cervical inflammation and pelvic inflammatory disease. Diagnosed by PCR.
Studying That Suits You
Use AI to generate personalized quizzes and flashcards to suit your learning preferences.
Related Documents
Description
This quiz focuses on the characteristics and pathogenicity of Pseudomonas aeruginosa and Legionella pneumophila. You will explore their environments, modes of transmission, and impact on human health. Evaluate your understanding of these important microorganisms prevalent in various settings.