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Questions and Answers
Which of the following factors would be most likely to increase metabolic rate, based on the provided information?
Which of the following factors would be most likely to increase metabolic rate, based on the provided information?
When energy intake is less than immediate energy requirements, it results in a(n):
When energy intake is less than immediate energy requirements, it results in a(n):
Which of the following is NOT a condition required for an accurate measurement of Basal Metabolic Rate (BMR)?
Which of the following is NOT a condition required for an accurate measurement of Basal Metabolic Rate (BMR)?
Based on the information provided, what is the primary method used to measure metabolic rate indirectly?
Based on the information provided, what is the primary method used to measure metabolic rate indirectly?
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Which of the following accurately describes the relationship between energy input and output in a neutral energy balance?
Which of the following accurately describes the relationship between energy input and output in a neutral energy balance?
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What is the standardized basal condition for determining BMR?
What is the standardized basal condition for determining BMR?
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Which of the following factors does NOT influence BMR?
Which of the following factors does NOT influence BMR?
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What is the primary purpose of 'internal work' in the context of energy expenditure?
What is the primary purpose of 'internal work' in the context of energy expenditure?
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What percentage of food energy is ultimately converted into heat during the process of energy metabolism?
What percentage of food energy is ultimately converted into heat during the process of energy metabolism?
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What is the basic unit of heat energy?
What is the basic unit of heat energy?
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Which of the following is NOT a standardized basal condition for determining BMR?
Which of the following is NOT a standardized basal condition for determining BMR?
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Why is BMR usually corrected for differences in body size?
Why is BMR usually corrected for differences in body size?
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Which of the following statements is TRUE about the relationship between food energy and heat loss?
Which of the following statements is TRUE about the relationship between food energy and heat loss?
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Which of the following statements accurately describes the role of very low-density lipoproteins (VLDLs) in lipid transport?
Which of the following statements accurately describes the role of very low-density lipoproteins (VLDLs) in lipid transport?
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What is the primary reason why the breakdown of proteins is a less efficient energy source compared to carbohydrates and lipids?
What is the primary reason why the breakdown of proteins is a less efficient energy source compared to carbohydrates and lipids?
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What is the equation used to calculate Low-density lipoprotein (LDL) cholesterol levels?
What is the equation used to calculate Low-density lipoprotein (LDL) cholesterol levels?
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Which of the following is NOT a factor contributing to the relative resistance of protein catabolism in the body?
Which of the following is NOT a factor contributing to the relative resistance of protein catabolism in the body?
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Which of the following statements about essential amino acids is TRUE?
Which of the following statements about essential amino acids is TRUE?
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Which of the following is NOT a factor that contributes to the short-term regulation of eating behavior?
Which of the following is NOT a factor that contributes to the short-term regulation of eating behavior?
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What is the primary role of the arcuate nucleus in the context of energy balance?
What is the primary role of the arcuate nucleus in the context of energy balance?
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Which of the following molecules acts as a molecular satiety signal, suppressing appetite and increasing weight loss?
Which of the following molecules acts as a molecular satiety signal, suppressing appetite and increasing weight loss?
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What is the primary effect of leptin on the arcuate nucleus?
What is the primary effect of leptin on the arcuate nucleus?
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Which of the following is NOT a potential cause of obesity?
Which of the following is NOT a potential cause of obesity?
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What is the primary goal of lifestyle modification in the treatment of obesity?
What is the primary goal of lifestyle modification in the treatment of obesity?
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Which of the following hormones is released from the duodenum during digestion and contributes to a feeling of fullness?
Which of the following hormones is released from the duodenum during digestion and contributes to a feeling of fullness?
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What is the role of melanocortins in energy homeostasis?
What is the role of melanocortins in energy homeostasis?
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Which of the following best describes the primary role of insulin in the context of long-term energy balance?
Which of the following best describes the primary role of insulin in the context of long-term energy balance?
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What is the primary function of the hormone ghrelin?
What is the primary function of the hormone ghrelin?
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Which of the following processes is NOT directly involved in the breakdown of fats for energy production?
Which of the following processes is NOT directly involved in the breakdown of fats for energy production?
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Which of the following correctly describes the role of ATP in anabolism?
Which of the following correctly describes the role of ATP in anabolism?
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Which of the following statements accurately describes the relationship between glycolysis and the citric acid cycle?
Which of the following statements accurately describes the relationship between glycolysis and the citric acid cycle?
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Which of the following is a correct statement about the role of essential fatty acids in lipid synthesis?
Which of the following is a correct statement about the role of essential fatty acids in lipid synthesis?
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Which of the following statements is TRUE about the energy yield from the breakdown of fatty acids compared to glucose?
Which of the following statements is TRUE about the energy yield from the breakdown of fatty acids compared to glucose?
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Which of the following is NOT a product of lipolysis?
Which of the following is NOT a product of lipolysis?
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What is the main difference between the synthesis of nonessential fatty acids and steroids?
What is the main difference between the synthesis of nonessential fatty acids and steroids?
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Which of the following processes utilizes energy produced by mitochondria?
Which of the following processes utilizes energy produced by mitochondria?
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Which of the following correctly describes the circulation of lipids in the bloodstream?
Which of the following correctly describes the circulation of lipids in the bloodstream?
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Which of the following statements correctly describes the relationship between gluconeogenesis and glycogenesis?
Which of the following statements correctly describes the relationship between gluconeogenesis and glycogenesis?
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Which vitamin primarily acts as a structural component of visual pigment?
Which vitamin primarily acts as a structural component of visual pigment?
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What is the main role of vitamin D in the body?
What is the main role of vitamin D in the body?
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Which statement best reflects the storage capabilities of water-soluble vitamins compared to fat-soluble vitamins?
Which statement best reflects the storage capabilities of water-soluble vitamins compared to fat-soluble vitamins?
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What condition might arise from a deficiency of vitamin C?
What condition might arise from a deficiency of vitamin C?
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Which vitamin plays a vital role in the synthesis of several clotting factors?
Which vitamin plays a vital role in the synthesis of several clotting factors?
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What is the defining characteristic that differentiates fever from hyperthermia?
What is the defining characteristic that differentiates fever from hyperthermia?
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Why might a person develop heatstroke even though they can still sweat?
Why might a person develop heatstroke even though they can still sweat?
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Which of the following mechanisms is NOT involved in the body's response to a raised hypothalamic set point during fever?
Which of the following mechanisms is NOT involved in the body's response to a raised hypothalamic set point during fever?
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What is the primary reason for the impaired temperature regulation observed in hypothermia?
What is the primary reason for the impaired temperature regulation observed in hypothermia?
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How does acclimatization to hot environments contribute to increased tolerance to heat?
How does acclimatization to hot environments contribute to increased tolerance to heat?
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Which of the following correctly describes the relationship between exercise hyperthermia and heatstroke?
Which of the following correctly describes the relationship between exercise hyperthermia and heatstroke?
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What is the primary difference between therapeutic hypothermia and artificial hypothermia?
What is the primary difference between therapeutic hypothermia and artificial hypothermia?
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Which of the following statements accurately describes the relationship between body temperature regulation and hydration status?
Which of the following statements accurately describes the relationship between body temperature regulation and hydration status?
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Why is it important to understand the mechanism of heat loss from the body?
Why is it important to understand the mechanism of heat loss from the body?
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What is the primary role of peripheral thermoreceptors in temperature regulation?
What is the primary role of peripheral thermoreceptors in temperature regulation?
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How does the hypothalamus maintain a constant core body temperature during exercise?
How does the hypothalamus maintain a constant core body temperature during exercise?
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Which of the following accurately describes the relationship between skin temperature and the hypothalamic set point?
Which of the following accurately describes the relationship between skin temperature and the hypothalamic set point?
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What is the physiological mechanism by which fever raises the hypothalamic set point?
What is the physiological mechanism by which fever raises the hypothalamic set point?
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How does aspirin help reduce fever?
How does aspirin help reduce fever?
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Which of the following is NOT a mechanism for increasing heat production in the body?
Which of the following is NOT a mechanism for increasing heat production in the body?
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What is the primary function of the hypothalamic thermoregulatory zone?
What is the primary function of the hypothalamic thermoregulatory zone?
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What happens when core body temperature falls below the hypothalamic set point?
What happens when core body temperature falls below the hypothalamic set point?
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Which of the following statements accurately describes the relationship between sweating and heat loss?
Which of the following statements accurately describes the relationship between sweating and heat loss?
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What is the primary function of the central thermoreceptors?
What is the primary function of the central thermoreceptors?
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How does the hypothalamus coordinate the response to exposure to cold?
How does the hypothalamus coordinate the response to exposure to cold?
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What is the primary role of brown fat in temperature regulation?
What is the primary role of brown fat in temperature regulation?
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What is the main difference between the thermoregulatory responses to heat exposure and cold exposure?
What is the main difference between the thermoregulatory responses to heat exposure and cold exposure?
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What is the primary mechanism by which the body attempts to maintain a stable core body temperature?
What is the primary mechanism by which the body attempts to maintain a stable core body temperature?
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Flashcards
Basal Metabolic Rate (BMR)
Basal Metabolic Rate (BMR)
The metabolic rate at rest under standardized conditions, necessary for basic body functions.
Energy Balance
Energy Balance
The relationship between energy input from food and energy output through work and metabolism.
First Law of Thermodynamics
First Law of Thermodynamics
Energy cannot be created or destroyed, only transformed from one form to another.
Calorie
Calorie
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Kcal (Kilocalorie)
Kcal (Kilocalorie)
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Energy Input
Energy Input
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Energy Output
Energy Output
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Metabolic Rate
Metabolic Rate
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Catabolism
Catabolism
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Anabolism
Anabolism
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Gluconeogenesis
Gluconeogenesis
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Glycolysis
Glycolysis
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Glycogenesis
Glycogenesis
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Glycogenolysis
Glycogenolysis
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Lipolysis
Lipolysis
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Beta-oxidation
Beta-oxidation
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Lipogenesis
Lipogenesis
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Lipoproteins
Lipoproteins
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Chylomicrons
Chylomicrons
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Essential Amino Acids
Essential Amino Acids
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Protein Catabolism Factors
Protein Catabolism Factors
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Fat-soluble Vitamins
Fat-soluble Vitamins
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Non-essential Amino Acids
Non-essential Amino Acids
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Hypothalamus
Hypothalamus
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Arcuate nucleus
Arcuate nucleus
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Neuropeptide Y (NPY)
Neuropeptide Y (NPY)
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Melanocortins
Melanocortins
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Leptin
Leptin
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Insulin
Insulin
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Ghrelin
Ghrelin
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Body Mass Index (BMI)
Body Mass Index (BMI)
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Obesity
Obesity
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Treatment of Obesity
Treatment of Obesity
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Direct Calorimetry
Direct Calorimetry
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Factors Increasing Metabolic Rate
Factors Increasing Metabolic Rate
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Energy Balance Types
Energy Balance Types
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Short-term Food Regulation
Short-term Food Regulation
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Vitamin A
Vitamin A
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Vitamin D
Vitamin D
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Water-Soluble Vitamins
Water-Soluble Vitamins
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Scurvy
Scurvy
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Hypothalamic Set Point
Hypothalamic Set Point
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Cessation of Fever
Cessation of Fever
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Hyperthermia
Hyperthermia
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Exercise Hyperthermia
Exercise Hyperthermia
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Heatstroke
Heatstroke
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Acclimatization
Acclimatization
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Hypothermia
Hypothermia
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Therapeutic Hypothermia
Therapeutic Hypothermia
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Heat Transfer Mechanisms
Heat Transfer Mechanisms
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Hypothalamus Role
Hypothalamus Role
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Fever Function
Fever Function
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Core Body Temperature
Core Body Temperature
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Sweating
Sweating
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Thermoreceptors
Thermoreceptors
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Shivering
Shivering
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Vasodilation
Vasodilation
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Vasoconstriction
Vasoconstriction
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Body Temperature Variation
Body Temperature Variation
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Thermoneutral Zone
Thermoneutral Zone
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Prostaglandins
Prostaglandins
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Study Notes
Metabolism - Energy Balance
- Metabolism is the sum of all chemical processes in an organism
- Energy balance is when energy input equals energy output
- Energy input comes from ingested food
- Energy output includes external work and internal work, like skeletal muscle not used in external work and life sustaining energy requiring processes
- The first law of thermodynamics states energy cannot be created or destroyed
- 50% of energy from ingested food is transferred to ATP
- 50% of the energy from ATP is lost as heat
- Net energy loss is 75% of energy from food
Learning Outcomes
- List standardized basal conditions used to determine basal metabolic rate
- Explain the factors influencing basal metabolic rate
- Discuss the regulation of food intake
- Define BMI and obesity
- Explain metabolism of carbohydrates, lipids, proteins and vitamins
Energy Input and Output
- Food is the primary input of energy
- External work is energy that leaves the body in the form of physical work
- Internal work is energy used in processes within the body, for instance, sustaining life
- Energy input and output must be equal to maintain a neutral energy balance
- Positive energy balance: Energy input exceeds output
- Negative energy balance: energy input is less than output
Metabolic Rate
- Metabolic rate is the rate of energy expenditure per unit of time
- Calorie is a unit of energy, measuring the amount of heat required to increase the temperature of 1g of water by 1°C
- Kilocalorie (kcal) is a larger unit used to measure the energy required by the human body (equivalent to 1000 calories)
- Basal metabolic rate (BMR) is the metabolic rate under standardized basal conditions used to determine the rate of required to maintain basic body functions at rest
Basal Metabolic Rate (BMR)
- Standardized basal conditions for determining BMR include a subject eating no food for at least 12 hours
- No physical activity
- No strenuous activity or exercise for at least 30 minutes to 1 hour before the test
- All mental and physical factors that cause excitement to be eliminated
- Comfortable room temperature (no shivering, no sweating)
- After a night of restful sleep (8 hrs sleep)
- BMR in average 70 kg man is 65 - 70 calories per hour
- BMR is usually corrected for body size differences
Methods of Measuring Metabolic Rate
- Direct calorimetry measures the total quantity of heat given out by the body per unit of time
- Indirect calorimetry determines the energy equivalent of oxygen (O2), and how much O2 is consumed in the form of a set of equations.
Factors Influencing the Metabolic Rate
- Factors that increase metabolic rate: Thyroid hormone, testosterone, growth hormone, fever, and physical activity
- Factors that decrease metabolic rate: Sleep, malnutrition, and low physical activity
Energy Balance
- To maintain a neutral energy balance, energy input must equal energy output
- A positive energy balance is when energy input exceeds output
- A negative energy balance is when energy input is less than the energy output
Regulation of Food Intake
- Short-term regulation deals with feeding pattern from meal to meal through appetite and satiety signals
- Appetite signals are the sensation of hunger
- Satiety signals indicate fullness and desire to stop eating
- Long-term regulation deals with energy balance and body weight
- Psychosociological / Environmental factors
- The hypothalamus controls food intake
- NPY (Neuropeptide Y) is a potent appetite stimulator
- Melanocortins are a group of hormones that regulate energy homeostasis
- Regulatory inputs to the arcuate nucleus, which is vital in maintaining energy balance, include Leptin, Insulin, and others (e.g. PYY3-36, Ghrelin, Cholecystokinin, and stomach distension)
- Leptin: amount of triglyceride fat stored in adipose tissue; suppress appetite, and weight loss
- Adipokines are hormones secreted by adipose tissue that regulate energy balance and metabolism
- Insulin plays a crucial part in long-term control of body weight
Long Term Maintenance of Energy Balance
- Food intake is primarily controlled by the hypothalamus
- NPY and melanocortins are important in the arcuate nucleus
- The arcuate nucleus plays a significant role in the long-term control of energy balance
- NPY is a critical component in triggering appetite
- Melanocortins have the opposite effect, suppressing appetite.
- Leptin and insulin affect the arcuate nucleus, both regulating long-term energy balance
- Leptin: amount of triglyceride fat stored in adipose tissue; suppress appetite, and weight loss
- Regulates short-term and long-term energy balance, as well as interactions within the hypothalamus, such as the arcuate nucleus' role in mediating signaling from different components
Short-Term Regulation of Eating Behavior
- Ghrelin: potent appetite stimulator
- PYY3-36: inhibits appetite for NPY secreting neurons
- Cholecystokinin: released from duodenum during digestion; signals satiety in the brainstem
- Stomach distension activates satiety center in brainstem
Putting It All Together
- Organic nutrients (carbohydrates, proteins, lipids) undergo various pathways starting from the mouth/intestine, converted within the body or released from cells, and ended up in the body tissues and other parts
Obesity
- Obesity occurs when consumed kilocalories exceed the amount of kilocalories burned and stored in the body
- Body mass index (BMI) is a measure of body fat proportion
- BMI = Weight (kg) / Height (m)²
Causes of Obesity
- Complex; involves physiological, lifestyle, and environmental factors
- Sedentary lifestyle
- Abnormal feeding behaviour
- Genetic factors
- Leptin-signaling pathway dysfunction
- Childhood overnutrition
- Hypothyroidism
- Other factors: increased energy intake, decreased energy expenditure
Treatment of Obesity
- Lifestyle modification (increase energy output, decrease energy input)
- Drugs (decreasing degree of hunger, altering lipid absorption in gut)
- Surgery (gastric bypass surgery)
Metabolism
- Chemical processes or reactions in an organism necessary for sustaining life
- Functions of metabolism include: metabolic turnover, growth, cell division, secretion, contraction, and propagation of action potentials
- This includes catabolism and anabolism
Carbohydrate Metabolism
- Generates ATP and other high-energy compounds by breaking down carbohydrates
- Glucose + Oxygen = Carbon dioxide + Water
- Processes of glycolysis, citric acid cycle, and electron transport chain are also included. (Specific details of each pathway are not detailed in these notes)
Lipid Metabolism
- Breakdown and synthesis of lipids
- Lipid catabolism (lipolysis) hydrolyses triglycerides into glycerol and fatty acids, and enzymes in cytosol convert glycerol into pyruvate
- Different enzymes also use beta-oxidation to convert fatty acids into Acetyl CoA
- Lipids and Energy Production
- For each 2-carbon fragment removed from a fatty acid, the cell gains 12 ATP from acetyl-CoA in the citric acid cycle. Cell can gain 120 ATP molecules from breakdown of one 18-carbon fatty acid molecule, and the fatty acid breakdown yields about 1.3 times the energy of glucose breakdown
- Lipid Synthesis (Lipogenesis)
- Essential fatty acids cannot be produced by the body; therefore they must be consumed (e.g. linoleic, linolenic acid)
- Glycerol synthesizes from dihydroxyacetone phosphate which is an intermediate product of glycolysis
- Nonessential fatty acids and steroids are synthesized from acetyl-Coa
Protein Metabolism
- Cellular proteins are recycled in the cytosol
- Peptide bonds are broken, and free amino acids are used to create new proteins
- When glucose and lipid reserves are inadequate, liver cells break down internal proteins
- Synthesizing proteins requires amino acids, both non-essential and essential amino acids, to build protein
- 11 non-essential amino acids
- 9 essential amino acids
- Three factors against protein catabolism
- Proteins are more difficult to break than complex carbohydrates or lipids
- A by-product, ammonium ion, is toxic to cells
- Proteins form important components of cells
Vitamins
- Essential organic nutrient that functions as a coenzyme in vital enzymatic reactions
- Deficiency in diet may cause metabolic deficits
- Vitamins can be assigned to two groups based on structure and characteristics
- Fat-soluble vitamins (A, D, E, K); absorbed with lipids in the digestive tract; significant reserve is stored in the liver; allows normal metabolism to continue for several months without dietary sources
- Water-soluble vitamins are important components of coenzymes, rapidly exchanged between fluids in the digestive tract and circulating blood; and excesses are excreted in urine; relatively less storage compared to fat-soluble vitamins
Lipid transport Distribution
- Lipoproteins
- Lipid-protein complexes (chylomicrons, VLDLs, IDL, LDL, and HDL) that transport lipids through the bloodstream
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Description
Test your knowledge on various factors influencing metabolic rate and how Basal Metabolic Rate (BMR) is measured. This quiz includes questions about energy balance, conditions for measuring BMR, and energy metabolism concepts. Perfect for students looking to deepen their understanding of metabolism.