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Questions and Answers
What is the primary goal of development synthesis in medicinal chemistry?
What is the primary goal of development synthesis in medicinal chemistry?
- To synthesize a clinical candidate as efficiently and safely as possible (correct)
- To identify the pharmacophore of a lead compound
- To modify natural products with similar structural motifs
- To synthesize lots of analogs as efficiently as possible
What approach involves identifying compounds with similar structures and modifying the synthetic route to apply to target compounds?
What approach involves identifying compounds with similar structures and modifying the synthetic route to apply to target compounds?
- Convergent synthesis
- Modification of natural products
- Identification of compounds with similar structures (correct)
- Retrosynthetic analysis
What is the advantage of convergent synthesis over linear synthesis?
What is the advantage of convergent synthesis over linear synthesis?
- It results in a higher overall yield (correct)
- It results in a lower overall yield
- It is more complex and difficult to design
- It requires more starting materials
What is the primary consideration when selecting a synthetic route?
What is the primary consideration when selecting a synthetic route?
What is the purpose of retrosynthetic analysis in medicinal chemistry?
What is the purpose of retrosynthetic analysis in medicinal chemistry?
What is the goal of hit to lead optimization in medicinal chemistry?
What is the goal of hit to lead optimization in medicinal chemistry?
What is the main difference between MK-2 and CDK-2?
What is the main difference between MK-2 and CDK-2?
What is the problem that was solved in the development of an analog-friendly route?
What is the problem that was solved in the development of an analog-friendly route?
What is the role of BINAP in the synthesis of 2-Phenyl Pyridines?
What is the role of BINAP in the synthesis of 2-Phenyl Pyridines?
What is the purpose of the mCPBA step in the development of an analog-friendly route?
What is the purpose of the mCPBA step in the development of an analog-friendly route?
What is the characteristic of the synthesis route described?
What is the characteristic of the synthesis route described?
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