11 Questions
What is the primary goal of development synthesis in medicinal chemistry?
To synthesize a clinical candidate as efficiently and safely as possible
What approach involves identifying compounds with similar structures and modifying the synthetic route to apply to target compounds?
Identification of compounds with similar structures
What is the advantage of convergent synthesis over linear synthesis?
It results in a higher overall yield
What is the primary consideration when selecting a synthetic route?
The yield and purity of the products
What is the purpose of retrosynthetic analysis in medicinal chemistry?
To design a synthetic route for a target compound
What is the goal of hit to lead optimization in medicinal chemistry?
To optimize a lead compound for pharmacodynamics and pharmacokinetics
What is the main difference between MK-2 and CDK-2?
Their selectivity models
What is the problem that was solved in the development of an analog-friendly route?
Incorporation of a chiral amine
What is the role of BINAP in the synthesis of 2-Phenyl Pyridines?
A ligand for the palladium catalyst
What is the purpose of the mCPBA step in the development of an analog-friendly route?
To form a sulfoxide bond
What is the characteristic of the synthesis route described?
Scaleable synthesis with little/no chromatography
Test your knowledge of medicinal chemistry by synthesizing efficient analogs and optimizing leads for pharmacokinetics and pharmacodynamics. Learn how to simplify hit identification and develop process chemistry for clinical candidates.
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