Podcast
Questions and Answers
What is the primary goal of development synthesis in medicinal chemistry?
What is the primary goal of development synthesis in medicinal chemistry?
- To synthesize a clinical candidate as efficiently and safely as possible (correct)
- To optimize lead compounds for PD and/or PK
- To synthesize multiple analogs efficiently
- To identify the pharmacophore of a lead compound
Which approach to designing a synthetic route involves modifying natural products with a common structural motif?
Which approach to designing a synthetic route involves modifying natural products with a common structural motif?
- Identification of compounds with similar structures
- Retrosynthetic analysis
- Modification of natural products (correct)
- Linear synthesis
What is the primary benefit of convergent synthesis compared to linear synthesis?
What is the primary benefit of convergent synthesis compared to linear synthesis?
- Fewer reactions are required
- Easier purification of products
- More stereospecific reactions
- Higher overall yield (correct)
What is the purpose of retrosynthetic analysis in designing a synthetic route?
What is the purpose of retrosynthetic analysis in designing a synthetic route?
What is the goal of hit to lead optimization in medicinal chemistry?
What is the goal of hit to lead optimization in medicinal chemistry?
What is the purpose of partial or semi-synthesis in medicinal chemistry?
What is the purpose of partial or semi-synthesis in medicinal chemistry?
What is the purpose of the Suzuki Reaction in Step 3 of 10?
What is the purpose of the Suzuki Reaction in Step 3 of 10?
What is the role of Pd(PPh3)4 in the Suzuki Reaction?
What is the role of Pd(PPh3)4 in the Suzuki Reaction?
What is the purpose of the mCPBA oxidation step?
What is the purpose of the mCPBA oxidation step?
What is the purpose of the Boc2O reaction in the first chromatography step?
What is the purpose of the Boc2O reaction in the first chromatography step?
What is the purpose of the CuBr2 reaction in the final step?
What is the purpose of the CuBr2 reaction in the final step?
What is the overall goal of the synthesis route?
What is the overall goal of the synthesis route?
What is the number of steps in the reported synthesis of chloropyridine advanced intermediate?
What is the number of steps in the reported synthesis of chloropyridine advanced intermediate?
What is the IC50 value of PF-3514411 against CDK-2?
What is the IC50 value of PF-3514411 against CDK-2?
What is the final step in the preparation of analogs?
What is the final step in the preparation of analogs?
What is the condition used for the reflux reaction?
What is the condition used for the reflux reaction?
What is the advantage of the reported synthesis route?
What is the advantage of the reported synthesis route?
