Medical Biology Lecture 1: Connective Tissue & Healing
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Questions and Answers

Which of the following is NOT a type of connective tissue?

  • Blood
  • Bone
  • Cartilage
  • Muscle tissue (correct)
  • What is the primary function of connective tissue?

  • Receiving and transmitting sensory information
  • Protecting the body from disease
  • Transporting oxygen and nutrients throughout the body
  • Providing support and structure to the body (correct)
  • Which type of connective tissue is characterized by its dense, tightly packed fibers, offering high tensile strength?

  • Cartilage
  • Blood
  • Loose connective tissue
  • Dense connective tissue (correct)
  • What is the main component of the extracellular matrix of connective tissue?

    <p>Proteins and ground substance (D)</p> Signup and view all the answers

    Which type of connective tissue is found in the ears, nose, and trachea, providing flexibility and support?

    <p>Cartilage (A)</p> Signup and view all the answers

    What is the term for the specialized cells that produce fibers and ground substance in connective tissue?

    <p>Fibroblasts (D)</p> Signup and view all the answers

    What is the function of elastin in connective tissue?

    <p>Providing flexibility and recoil (B)</p> Signup and view all the answers

    Which of the following connective tissues is primarily responsible for the body's ability to withstand pulling forces?

    <p>Tendons (B)</p> Signup and view all the answers

    What is the non-cellular component of connective tissue called?

    <p>Extracellular matrix (A)</p> Signup and view all the answers

    What is the function of collagen fibers in connective tissue?

    <p>Provide tensile strength (B)</p> Signup and view all the answers

    Which type of fiber in connective tissue is responsible for providing elasticity?

    <p>Elastin (C)</p> Signup and view all the answers

    What is the main function of the ground substance in connective tissue?

    <p>Facilitates cell communication (B)</p> Signup and view all the answers

    Which of these options is responsible for determining the properties of different types of connective tissue?

    <p>All of the above (D)</p> Signup and view all the answers

    Which of the following statements is true about connective tissue?

    <p>Connective tissue provides support and connects other tissues together in the body. (D)</p> Signup and view all the answers

    Which type of fiber forms a network for support in connective tissue?

    <p>Reticulin (B)</p> Signup and view all the answers

    What is the main goal of the inflammatory phase of wound healing?

    <p>To remove dead cells and pathogens from the wound site. (D)</p> Signup and view all the answers

    Which of the following is NOT a characteristic of inflammation?

    <p>Numbness (paresthesia) (D)</p> Signup and view all the answers

    Which of the following chemicals is NOT a key inflammatory mediator?

    <p>Collagen (A)</p> Signup and view all the answers

    What does vasodilation, a result of inflammatory mediators, directly cause in the wound area?

    <p>Increased blood flow, leading to redness and warmth. (A)</p> Signup and view all the answers

    What effect does increased permeability of blood vessels, caused by inflammatory mediators, have on the wound?

    <p>It leads to fluid leakage into the surrounding tissues, causing swelling and pain. (A)</p> Signup and view all the answers

    What is the primary role of white blood cells in the inflammatory phase of wound healing?

    <p>To remove dead cells and pathogens from the wound site. (B)</p> Signup and view all the answers

    How long does the inflammatory phase typically last?

    <p>1-5 days (C)</p> Signup and view all the answers

    Which of the following is NOT a factor that can trigger an inflammatory response?

    <p>Normal blood pressure fluctuations (C)</p> Signup and view all the answers

    Which type of collagen provides high tensile strength, stronger than steel, and is found in bone, tendons, ligaments, and skin?

    <p>Type I (D)</p> Signup and view all the answers

    What is the primary function of proteoglycans in the extracellular matrix?

    <p>Bind water and regulate the viscosity of the matrix (A)</p> Signup and view all the answers

    What is the relationship between glycosaminoglycans (GAGs) and proteoglycans?

    <p>GAGs are sugar chains that attach to a core protein to form proteoglycans (D)</p> Signup and view all the answers

    Which of the following is NOT a component of the extracellular matrix (ECM)?

    <p>Nucleic acids (B)</p> Signup and view all the answers

    How do proteoglycans contribute to the stability of collagen fibers?

    <p>By binding water and creating a gel-like matrix that surrounds and supports collagen fibers (C)</p> Signup and view all the answers

    Which type of collagen is primarily found in cartilage?

    <p>Type II (B)</p> Signup and view all the answers

    What is the main difference between the ECM in loose connective tissue and dense connective tissue?

    <p>Loose connective tissue is more flexible and less dense than dense connective tissue (A)</p> Signup and view all the answers

    What is the role of hyaluronan in proteoglycan aggregates?

    <p>Forms a central backbone to which multiple proteoglycans attach (C)</p> Signup and view all the answers

    What is the primary goal of functional exercise during the proliferative phase of wound healing?

    <p>To strengthen collagen fibers in the correct direction (B)</p> Signup and view all the answers

    Which phase of wound healing follows the inflammatory phase?

    <p>Proliferative phase (B)</p> Signup and view all the answers

    During the remodeling phase of wound healing, what type of collagen replaces type III collagen?

    <p>Type I collagen (D)</p> Signup and view all the answers

    What activity should a physiotherapist encourage during the remodeling phase of wound healing?

    <p>Gradually increasing functional load (B)</p> Signup and view all the answers

    What is the purpose of cross-linking in the remodeling phase of wound healing?

    <p>To enhance the strength of collagen fibers (A)</p> Signup and view all the answers

    What effect does increased permeability have on surrounding tissues?

    <p>Pain and swelling (B)</p> Signup and view all the answers

    What is the primary purpose of white blood cells (WBC) during inflammation?

    <p>Clear damaged tissue and pathogens (C)</p> Signup and view all the answers

    Which phase of wound healing involves the formation of granulation tissue?

    <p>Proliferative phase (D)</p> Signup and view all the answers

    What specific process do fibroblasts undergo during the proliferative phase?

    <p>Mitosis (D)</p> Signup and view all the answers

    What type of collagen is primarily produced during the initial stages of the proliferative phase?

    <p>Collagen type III (A)</p> Signup and view all the answers

    What is the main purpose of angiogenesis in the wound healing process?

    <p>To form new blood vessels (B)</p> Signup and view all the answers

    During which phase of wound healing does the extracellular matrix (ECM) begin to form?

    <p>Proliferative phase (A)</p> Signup and view all the answers

    What is a key role of fibroblasts in the context of tissue healing?

    <p>Producing extracellular matrix (B)</p> Signup and view all the answers

    Flashcards

    Functional exercises

    Lightly load movements to promote healing and strengthen tissue.

    Inflammatory phase

    The first stage of wound healing lasting 1-5 days, characterized by inflammation.

    Proliferative phase

    The stage of wound healing from 5-21 days where tissue formation occurs.

    Remodeling phase

    Final phase of wound healing where tissue is restructured over time.

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    Collagen types in healing

    Collagen type III is replaced by stronger type I during remodeling.

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    Connective Tissue

    A group of similar cells working together to perform a specific function.

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    Types of Tissues

    There are four main types of tissues in the body: epithelial, nervous, muscular, and connective.

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    Epithelial Tissue

    Covers body surfaces and lines cavities, protects against damage and dehydration.

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    Nervous Tissue

    Made up of nerve cells that transmit information throughout the body.

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    Muscle Tissue

    Enables movement of body parts through contraction.

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    Types of Connective Tissue

    Includes dense and loose connective tissue, bone, cartilage, and blood.

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    Dense Connective Tissue

    Examples include tendons, ligaments, and capsules; strong and supportive.

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    Healing Phases of Wound Healing

    The stages through which the body repairs injuries: hemostasis, inflammation, proliferation, and remodeling.

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    White Blood Cells (WBC)

    Defense cells that clean damaged tissue and pathogens.

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    Increased Permeability

    Higher permeability leading to pain, swelling, and loss of function.

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    Inflammatory Mediators

    Substances that cause vasodilation and increased permeability.

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    Fibroblasts

    Cells that produce extracellular matrix (ECM) in connective tissue.

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    Extracellular Matrix (ECM)

    A network that provides structural support to cells in tissues.

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    Angiogenesis

    Formation of new blood vessels during tissue healing.

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    Wound Healing

    The process by which the body repairs damaged tissue.

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    Characteristics of Inflammation

    Includes heat, redness, swelling, pain, and loss of function.

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    Vasodilatation

    The widening of blood vessels that occurs during inflammation, leading to heat and redness.

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    Type I collagen

    A type of collagen found in bone, tendons, ligaments, and skin; has high tensile strength.

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    Type II collagen

    A type of collagen primarily found in cartilage.

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    Proteoglycans

    Molecules made of protein and sugar chains that bind water and stabilize collagen fibers.

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    Glycosaminoglycans (GAGs)

    Complex carbohydrates that are part of proteoglycans and help in water binding.

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    Tensile strength

    The resistance of a material to breaking under tension.

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    Proteoglycan aggregates

    Structures formed by proteoglycans that bind with water and stabilize tissue.

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    Viscosity

    A measure of a fluid's resistance to flow; higher with more GAGs.

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    Components of Connective Tissue

    Made up of cells and the extracellular matrix, including fibers and ground substance.

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    Collagen Fibers

    Major protein fibers in connective tissue that provide tensile strength.

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    Elastin Fibers

    Protein fibers allowing connective tissues to stretch and return to their original shape.

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    Reticulin Fibers

    Thin fibers that form a supportive mesh in certain connective tissues, providing structure.

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    Ground Substance

    The non-cellular material in connective tissue that fills the space between cells and fibers.

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    Study Notes

    Medical-Biological Lecture Notes

    • The lecture is about connective tissue and wound healing.
    • There are seven lectures in total.
    • Lecture 1: Connective tissue and wound healing.
    • Lecture 2: Pain, part I.
    • Lecture 3: Bone tissue and fractures.
    • Lecture 4: Shoulder anatomy.
    • Lecture 5: Frozen shoulder (knowledge clip).
    • Lecture 6: Spine (physical) + osteoarthritis (knowledge clip).
    • Lecture 7: Tendons and tendinopathy + pain part II.

    Common Terms in Connective Tissue

    • Fibroblasts
    • Extracellular matrix
    • Tissue
    • Cells
    • Proteoglycans
    • Ground substance
    • Collagen
    • Cross-links
    • Aggregates
    • Elastine
    • Reticuline
    • Glycosaminoglycans
    • Dense connective tissue
    • Loose connective tissue

    Learning Objectives

    • Describe the function and composition and structure of various tissues.
    • Explain what happens during inflammation.
    • Explain what happens during the different phases of wound healing.

    Tissue Types

    • Tissue = a group of similar cells that work together to perform a common function.
    • Four types of tissue:
      • Epithelial tissue: Covers body cavities and protects against damage and dehydration.
      • Connective tissue: Fills in spaces, protects and insulates, and provides support to the body.
      • Muscle tissue: Allows movement of body parts through contraction.
      • Nervous tissue: Composed of nerve cells, carrying information throughout the body.

    Connective Tissue Types

    • Loose connective tissue (under the skin)
    • Adipose tissue
    • Blood
    • Dense connective tissue (ligaments)
    • Cartilage (at the end of a bone)
    • Bone
    • Dense connective tissue (tendons, ligaments, capsules)
    • Loose connective tissue (fat, connective tissue around organs)
    • Cartilage
    • Blood

    Connective Tissue - Structure

    • Connective tissue consists of cells and extracellular matrix (ECM).
    • ECM: Non-cellular components of connective tissue.
      • Fibres (collagen, elastin, reticulin).
      • Ground substance (proteoglycans).

    Connective Tissue - Fiber Types

    • Collagen (strength)
    • Elastin (elasticity)
    • Reticulin (network/filling)

    Connective Tissue - Collagen Types

    • Type I: Bone, tendon, ligament, skin (high tensile strength, stronger than steel)
    • Type II: Cartilage
    • Type III: Wound healing, blood vessels, skin

    Connective Tissue - Ground Substance - Proteoglycans

    • Proteoglycans = protein + sugar chains.
    • Combine protein and sugar.
    • Binds water.
    • More GAGs = higher viscosity (thicker).
    • Stabilizes collagen fibers.
    • Proteoglycans often form aggregates.

    Wound Healing - 3 Phases

    • Inflammatory phase (1-5 days)
    • Proliferative phase (5-21 days)
    • Remodeling phase (varies)

    Wound Healing - Inflammatory Phase

    • Reaction to tissue damage.
    • Many possible causes: physical trauma, burns, irritants, infections.
    • Goal: Prepare tissue for repair, prevent spread and remove debris.
      • Coagulation Prevents spread.
      • Removal: Damaged cell, matrix fragments, pathogens.

    Inflammation Characteristics

    • Heat (calor)
    • Redness (rubor)
    • Swelling (tumor)
    • Pain (dolor)
    • Loss of function (functio laesa)

    Wound Healing - Inflammatory Mediators

    • Substances released during tissue damage activating the inflammatory response:
      • Histamine, kinins and prostaglandins.

    Wound Healing - Proliferative Phase

    • Create initial new tissue.
      • Formation of new blood vessels (angiogenesis)
      • Production of ECM by fibroblasts.
      • Formation of granulation tissue .

    Wound Healing - Remodeling Phase

    • Reshape tissue to resemble the original tissue.
      • Fibroblasts continue to form and remodel structure
      • Collagen type III replaced by collagen type I
      • Cross-linking increases tissue strength.
    • Increasing functional load/stress/exercise can support the reformation process.

    Additional Information and Summary

    • Future lecture on pain.
    • The notes are based on a medical-biological presentation.
    • The information focuses on tissue types, function and structure, and wound healing.

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    Description

    This quiz focuses on the first lecture of a seven-part series, covering the structure, function, and types of connective tissue, as well as the phases of wound healing. Test your knowledge on key terms like fibroblasts, collagen, and the extracellular matrix, and understand the biological processes involved in inflammation and healing.

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