Tissue Remodelling in Wound Healing

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What is the primary mechanism of repair when injury involves only the epithelial layer?

Degradation of matrix metalloproteinases

Epithelial regeneration (correct)

Collagenisation

Migration of connective tissue

Which type of collagen is predominant during the early stages of wound healing?

Type II collagen

Type III collagen (correct)

Type I collagen

Type IV collagen

What is the role of matrix metalloproteinases (MMPs) in tissue degradation?

Breakdown of extracellular matrix (correct)

Promotion of collagen synthesis

Enhancement of epithelial regeneration

Increase in wound strength

What happens during wound healing by second intention?

More granulation tissue formation Signup and view all the answers

Which process involves the synthesis of extracellular matrix (ECM) proteins?

Collagenisation Signup and view all the answers

What characterizes wound healing when there is extensive cell or tissue loss?

A combination of regeneration and scarring Signup and view all the answers

Which cellular component is responsible for the close of the wound by pulling margins to the center?

Myofibroblasts Signup and view all the answers

What is the main role of capillary loops in the wound healing process?

Develop new blood vessels Signup and view all the answers

What is the function of vascular endothelial growth factors (VEGF) in wound healing?

Induce angiogenesis by promoting new blood vessel formation Signup and view all the answers

Which characteristic is associated with mature scar tissue?

Dense collagen and scattered vascular channels Signup and view all the answers

In which phase of wound healing do fibroblasts migrate towards the center and produce collagen?

Proliferative phase Signup and view all the answers

What is the primary role of myofibroblasts in wound healing?

Close the wound by pulling margins to the center Signup and view all the answers

Which cell type is responsible for the contraction of myofibroblasts that reduces the volume of tissue during repair?

Myofibroblasts Signup and view all the answers

What is the main function of the extracellular matrix (ECM) in tissues?

Cell proliferation control Signup and view all the answers

What component of the ECM provides tissues with resilience and lubrication?

Proteoglycans and hyaluronan Signup and view all the answers

What factor is responsible for the conversion of granulation tissue scaffolding into a pale, avascular scar during wound healing?

Transforming Growth Factor β (TGF-β) Signup and view all the answers

What is the consequence of excessive contraction during repair that can occur in the gastrointestinal tract?

Stricture Signup and view all the answers

Which growth factor is primarily responsible for fibroblasts depositing extracellular matrix (ECM) during tissue repair?

Platelet derived growth factor (PDGF) Signup and view all the answers

What determines whether a wound heals by first or second intention?

The nature of the wound Signup and view all the answers

In wound healing, what occurs during the proliferation phase?

Formation of granulation tissue Signup and view all the answers

What is the main function of granulation tissue in wound healing?

To facilitate drainage to the surface Signup and view all the answers

Why does wound contraction occur in large wounds?

To reduce the size of the wound for closure Signup and view all the answers

During skin regeneration, what is lost as specialised tissues heal?

Specialised skin structures like sweat glands and hair follicles Signup and view all the answers

At what point does a wound reach about 70-80% strength during the healing process?

Around 3 months when inflammation persists Signup and view all the answers

Which type of abnormal healing is more common in darker skin?

Keloid Signup and view all the answers

What is the main cause of deficient scar formation according to the text?

Mechanical stress like coughing and vomiting Signup and view all the answers

Which process leads to the replacement of normal tissue by fibrosis?

Migration and proliferation of fibroblasts and myofibroblasts Signup and view all the answers

What term describes the process where an injury results in permanent damage causing dysfunction?

Keloid Signup and view all the answers

Which cells are described as labile, stable, or permanent/fixed in terms of their capacity for regeneration?

Epithelial cells Signup and view all the answers

What is the key difference between healing by primary intention and healing by secondary intention?

The type of tissue injury Signup and view all the answers

Which type of cells are capable of proliferating continuously and maturing from tissue stem cells?

Labile cells Signup and view all the answers

Which cells are described as terminally differentiated and nonproliferative postnatally?

Permanent cells Signup and view all the answers

Which stage of the cell cycle are stable (quiescent) cells typically in?

G0 Signup and view all the answers

Which types of cells are capable of dividing in response to injury or loss of tissue mass?

Fibroblasts Signup and view all the answers

Which type of cells are found in the parenchyma of most solid tissues like the liver, kidney, and pancreas?

Hepatocytes Signup and view all the answers

Which cell type has minimal proliferative activity in normal state but is capable of dividing in response to injury?

Smooth muscle cells Signup and view all the answers

What is the main consequence of excessive contraction during repair in the gastrointestinal tract?

Stricture formation around a lumen Signup and view all the answers

Which growth factor plays a significant role in fibroblasts depositing extracellular matrix (ECM) during tissue repair?

Transforming Growth Factor β (TGF-β) Signup and view all the answers

What is the primary function of myofibroblasts during wound healing?

Contribute to tissue contraction Signup and view all the answers

Which component of the extracellular matrix (ECM) provides tissues with resilience and lubrication?

Proteoglycans and hyaluronan Signup and view all the answers

What is a common problem that may arise from the contraction of granulation tissue during repair?

Tissue stricture Signup and view all the answers

Why does depositing Extracellular matrix (ECM) become crucial as repair progresses?

To provide mechanical support and scaffold for tissue renewal Signup and view all the answers

Which type of abnormal healing is characterized by excessive scarring that grows rapidly but regresses?

Hypertrophic scar Signup and view all the answers

What is the main consequence of persistent tissue injury according to the text?

Chronic inflammation and loss of tissue architecture Signup and view all the answers

Which cells play a key role in the deposition of collagen and other extracellular matrix (ECM) proteins during tissue repair?

Fibroblasts Signup and view all the answers

What is the primary mechanism by which chronic inflammation leads to fibrosis?

Replacement of normal tissue by fibrosis Signup and view all the answers

Which type of injury may result in residual scarring according to the text?

Pressure sores Signup and view all the answers

What is the consequence of wound contraction in terms of joint mobility during repair?

Limited joint mobility Signup and view all the answers

What is the primary difference between labile and stable cells in terms of regeneration?

Stable cells are more prone to scarring during regeneration compared to labile cells. Signup and view all the answers

What role does the basement membrane play in the regeneration of damaged epithelial cells?

The basement membrane supports the proliferation and differentiation of residual cells during regeneration. Signup and view all the answers

During which phase of repair does the formation of connective tissue deposited by fibroblasts occur?

In the remodelling phase Signup and view all the answers

What is the consequence of extensive tissue damage or damage to permanent/non-dividing cells during repair?

Replacement of injured cells with connective tissue leading to scar formation Signup and view all the answers

What is the primary function of granulation tissue in wound healing?

To promote angiogenesis and produce collagen fibers for scar formation Signup and view all the answers

What characterizes the process of repair by scarring according to Dr. C.Hand?

Formation of a scar when lost tissue cannot be replaced, involving connective tissue replacement Signup and view all the answers

What is the primary function of matrix metalloproteinases (MMPs) in tissue degradation during wound healing?

Breaking down the extracellular matrix Signup and view all the answers

During wound healing, what characterizes the process when there is extensive cell or tissue loss?

More debris and granulation tissue Signup and view all the answers

Which type of wound healing involves the loss of tissue and unopposed wound edges?

Healing by second intention Signup and view all the answers

What is the primary function of myofibroblasts in the wound healing process?

Contracting to reduce tissue volume Signup and view all the answers

Which type of collagen is predominant during the early stages of wound healing?

Collagen type III Signup and view all the answers

What is the main role of granulation tissue in the wound healing process?

Scaffolding for capillary growth and collagen deposition Signup and view all the answers

Tissue Remodelling in Wound Healing

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Questions and Answers

What is the primary mechanism of repair when injury involves only the epithelial layer?

Which type of collagen is predominant during the early stages of wound healing?

What is the role of matrix metalloproteinases (MMPs) in tissue degradation?

What happens during wound healing by second intention?

Which process involves the synthesis of extracellular matrix (ECM) proteins?

What characterizes wound healing when there is extensive cell or tissue loss?

Which cellular component is responsible for the close of the wound by pulling margins to the center?

What is the main role of capillary loops in the wound healing process?

What is the function of vascular endothelial growth factors (VEGF) in wound healing?

Which characteristic is associated with mature scar tissue?

In which phase of wound healing do fibroblasts migrate towards the center and produce collagen?

What is the primary role of myofibroblasts in wound healing?

Which cell type is responsible for the contraction of myofibroblasts that reduces the volume of tissue during repair?

What is the main function of the extracellular matrix (ECM) in tissues?

What component of the ECM provides tissues with resilience and lubrication?

What factor is responsible for the conversion of granulation tissue scaffolding into a pale, avascular scar during wound healing?

What is the consequence of excessive contraction during repair that can occur in the gastrointestinal tract?

Which growth factor is primarily responsible for fibroblasts depositing extracellular matrix (ECM) during tissue repair?

What determines whether a wound heals by first or second intention?

In wound healing, what occurs during the proliferation phase?

What is the main function of granulation tissue in wound healing?

Why does wound contraction occur in large wounds?

During skin regeneration, what is lost as specialised tissues heal?

At what point does a wound reach about 70-80% strength during the healing process?

Which type of abnormal healing is more common in darker skin?

What is the main cause of deficient scar formation according to the text?

Which process leads to the replacement of normal tissue by fibrosis?

What term describes the process where an injury results in permanent damage causing dysfunction?

Which cells are described as labile, stable, or permanent/fixed in terms of their capacity for regeneration?

What is the key difference between healing by primary intention and healing by secondary intention?

Which type of cells are capable of proliferating continuously and maturing from tissue stem cells?

Which cells are described as terminally differentiated and nonproliferative postnatally?

Which stage of the cell cycle are stable (quiescent) cells typically in?

Which types of cells are capable of dividing in response to injury or loss of tissue mass?

Which type of cells are found in the parenchyma of most solid tissues like the liver, kidney, and pancreas?

Which cell type has minimal proliferative activity in normal state but is capable of dividing in response to injury?

What is the main consequence of excessive contraction during repair in the gastrointestinal tract?

Which growth factor plays a significant role in fibroblasts depositing extracellular matrix (ECM) during tissue repair?

What is the primary function of myofibroblasts during wound healing?

Which component of the extracellular matrix (ECM) provides tissues with resilience and lubrication?

What is a common problem that may arise from the contraction of granulation tissue during repair?

Why does depositing Extracellular matrix (ECM) become crucial as repair progresses?

Which type of abnormal healing is characterized by excessive scarring that grows rapidly but regresses?

What is the main consequence of persistent tissue injury according to the text?

Which cells play a key role in the deposition of collagen and other extracellular matrix (ECM) proteins during tissue repair?

What is the primary mechanism by which chronic inflammation leads to fibrosis?

Which type of injury may result in residual scarring according to the text?

What is the consequence of wound contraction in terms of joint mobility during repair?

What is the primary difference between labile and stable cells in terms of regeneration?

What role does the basement membrane play in the regeneration of damaged epithelial cells?

During which phase of repair does the formation of connective tissue deposited by fibroblasts occur?

What is the consequence of extensive tissue damage or damage to permanent/non-dividing cells during repair?

What is the primary function of granulation tissue in wound healing?

What characterizes the process of repair by scarring according to Dr. C.Hand?

What is the primary function of matrix metalloproteinases (MMPs) in tissue degradation during wound healing?

During wound healing, what characterizes the process when there is extensive cell or tissue loss?

Which type of wound healing involves the loss of tissue and unopposed wound edges?

What is the primary function of myofibroblasts in the wound healing process?

Which type of collagen is predominant during the early stages of wound healing?

What is the main role of granulation tissue in the wound healing process?

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