30 Questions
What is the function of quiescence in the cell cycle?
To allow cells to persist in a non-dividing state and protect themselves from damage
Which state is characterized by the ability to re-enter G1 of the cell cycle after passing the restriction point?
Quiescence
What is the irreversible state that cells in G1 can enter?
Senescence
What is the function of senescence in the cell cycle?
To irreversibly arrest cell proliferation
Which phase of the cell cycle is quiescence most closely associated with?
G0 phase
In what phase can cells in G1 enter senescence?
G0 phase
What is the main characteristic that differentiates quiescent cells from senescent and terminally differentiated cells?
Ability to reenter the cell cycle
Which of the following cell types is NOT considered quiescent?
Senescent cells
What phase do cells enter during the resting phase outside of the cell cycle?
G0
Which stimuli induce quiescence by decreasing the levels of cyclin D/E and CDK4/6?
CDK inhibitors
What is the main function of stem cell dormancy?
To reduce the accumulation of molecular damage
Which molecules are expressed at high levels in quiescent cells as CDK inhibitors?
$p21$, $p27$, and $p16$
What kind of state is quiescence considered to be?
An actively regulated state
What do quiescent stem cells retain the capacity to do?
$Reenter$ metabolic and cell-cycle activity
$T$ lymphocytes exit from quiescence upon binding of a cognate antigen to the $T$ cell receptor. What is this essential for?
$Promoting$ immune response
What is involved in regulating the exit and reentry of stem cells from/into quiescence?
Concerted regulation of biochemical and molecular processes
What is the reversible state of proliferative arrest in which cells are not actively dividing, and yet retain the capacity to reenter the cell cycle upon receiving an appropriate stimulus?
Quiescence
What is an irreversible state that cells in G1 can enter?
Senescence
Which state is characterized by the ability to re-enter G1 of the cell cycle after passing the restriction point?
Quiescence
What is the main characteristic that differentiates quiescent cells from senescent and terminally differentiated cells?
Ability to re-enter G1 of the cell cycle
What do quiescent stem cells retain the capacity to do?
Re-enter the cell cycle
What phase of the cell cycle is quiescence most closely associated with?
G0 phase
What is the main function of stem cell dormancy?
To reduce the accumulation of molecular damage and metabolic activities
What are the stimuli that induce quiescence by decreasing the levels of cyclin D/E and CDK4/6?
Nutrient deprivation
What is the main characteristic that differentiates quiescent cells from senescent and terminally differentiated cells?
Capacity to reenter the cell cycle
What is the reversible state of proliferative arrest in which cells are not actively dividing, and yet retain the capacity to reenter the cell cycle upon receiving an appropriate stimulus?
Quiescence
What do quiescent stem cells retain the capacity to do?
Reenter metabolic and cell-cycle activity
Which phase of the cell cycle is quiescence most closely associated with?
G1 phase
$T$ lymphocytes exit from quiescence upon binding of a cognate antigen to the $T$ cell receptor. What is this essential for?
An appropriate immune response
What is the irreversible state that cells in $G_1$ can enter?
Senescence
Test your knowledge of the course syllabus for MBG307: The Cell Cycle. Topics include overview of the eukaryotic cell cycle, model organisms in cell cycle analysis, cell cycle control system, mitotic spindle and cytokinesis, and more.
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