MBBS Year 1 Gastrointestinal Lectures: Bile and Biliary System

MBBS Year 1 Gastrointestinal Lectures

• The lectures cover an overview of the digestive system, digestion and absorption of nutrients, salivary, gastric and pancreatic secretions, bile and biliary system, and motility of the gut.

Bile and Biliary System (L4)

• Learning objectives include discussing relationships between bile acid structures and their physiological function, delineating relationships between bile acids and cholesterol, describing functions of bile acids in the human intestine, outlining clinical consequences of bile acid deficiency, and describing the transport of bilirubin in plasma and liver.

Bile Flow and Liver Blood Flow

• There is a relationship between bile flow and liver blood flow, with oxygen delivery affecting bile flow.

Biliary Pressure and Blood Pressure

• There is a relationship between biliary pressure and blood pressure.

Bile Acid Composition

• Bile acids are concentrated in the gallbladder.

Pathophysiology of Biliary Disease

• Biliary disease can be caused by abnormalities in bile composition, biliary anatomy, and function.
• The liver determines the chemical composition of bile, which may be modified later by the gallbladder and biliary epithelium.
• Cholesterol, which is insoluble in water, comes into solution by forming vesicles with phospholipids (principally lecithin) or mixed micelles with bile salts and phospholipids.

This quiz covers the bile and biliary system, including the relationships between bile acid structures and their physiological function, and the functions of bile acids in the human body.