Podcast
Questions and Answers
What is the approximate genome size of the helical nucleocapsids with negative sense ssRNA genome?
What is the approximate genome size of the helical nucleocapsids with negative sense ssRNA genome?
Where was the first outbreak of Marburg virus?
Where was the first outbreak of Marburg virus?
What is the most fatal type of Ebolavirus?
What is the most fatal type of Ebolavirus?
What is the likely source of transmission for Marburg and Ebola viruses to primates?
What is the likely source of transmission for Marburg and Ebola viruses to primates?
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What is the function of sGP, a protein released from infected cells?
What is the function of sGP, a protein released from infected cells?
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What is the potential role of minor nucleocapsid protein VP30 in Ebola virus?
What is the potential role of minor nucleocapsid protein VP30 in Ebola virus?
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Where is VP40, the most abundant viral protein, located?
Where is VP40, the most abundant viral protein, located?
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What may aid in restoring endothelial barrier function in Ebola virus infection?
What may aid in restoring endothelial barrier function in Ebola virus infection?
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In those who survive Ebola virus infection, what is suggested to help prevent disease recrudescence?
In those who survive Ebola virus infection, what is suggested to help prevent disease recrudescence?
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What is a potential function of sGP, a protein released from infected cells?
What is a potential function of sGP, a protein released from infected cells?
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What is the genome type of Ebola virus?
What is the genome type of Ebola virus?
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Where does Ebola virus replication occur?
Where does Ebola virus replication occur?
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Which cellular receptors does Ebola virus glycoprotein (GP) mediate binding to?
Which cellular receptors does Ebola virus glycoprotein (GP) mediate binding to?
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What is the lethality percentage associated with Ebola virus?
What is the lethality percentage associated with Ebola virus?
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Which proteins are packaged in the Ebola virus virion?
Which proteins are packaged in the Ebola virus virion?
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What kind of infections among humans are limited to close contacts for Filovirus?
What kind of infections among humans are limited to close contacts for Filovirus?
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What does Ebola virus use to make two glycoproteins from the same gene?
What does Ebola virus use to make two glycoproteins from the same gene?
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Where does Ebola virus replication occur?
Where does Ebola virus replication occur?
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What is included in the Ebola virus virion?
What is included in the Ebola virus virion?
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Study Notes
Ebola Virus Replication and Glycoprotein Synthesis
- Ebola virus lethality can be as high as 90%
- Filovirus infections among humans are limited to close contacts, such as family members and medical staff
- Ebola virus has a linear, negative sense, single-stranded RNA genome with seven genes
- Most Ebola virus proteins are packaged in the virion, including nucleocapsid protein (NP), RNA polymerase cofactor (VP35), and envelope glycoproteins (GP, GP1, GP2)
- Ebola virus makes additional secreted glycoproteins (sGP, delta-peptide)
- Ebola virus has mRNA editing, whereas Marburg virus does not
- Ebola virus replication occurs in the cytoplasm and involves the synthesis of antigenome RNA
- The cytoplasm of infected cells contains inclusion bodies containing viral nucleocapsid
- Ebola virus uses RNA editing to make two glycoproteins from the same gene: sGP and GP
- Ebola virus glycoprotein (GP) mediates attachment and entry into host cells by fusion
- GP mediates binding to multiple cellular receptors, including asialoglycoprotein receptor, folate receptor-alpha, integrin, and DC-Signs
- Replication-deficient pseudotypes are used to study which viral proteins bind to which cellular receptors
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Description
Test your knowledge about the Marburg virus, including its nucleocapsids, genome size, historical outbreaks, and transmission. Learn more about this re-emerging virus and its impact on public health.
