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Marburg Virus Quiz
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Marburg Virus Quiz

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Questions and Answers

What is the approximate genome size of the helical nucleocapsids with negative sense ssRNA?

  • ~5-8kb
  • ~10-12kb
  • ~20-25kb
  • ~15-19kb (correct)
  • Where was the first outbreak of Marburg virus?

  • London and Paris
  • Marburg and Frankfurt, Germany (correct)
  • Caire and Sudan
  • New York and Los Angeles
  • Which species of Ebolavirus is the most fatal type?

  • Bundibugyo EBOV
  • Sudan EBOV
  • Zaire EBOV (correct)
  • Reston EBOV
  • What is the likely source of transmission of Marburg and Ebola viruses to primates?

    <p>Fruit bats (zoonotic spread)</p> Signup and view all the answers

    What is the function of sGP, a protein released from infected cells?

    <p>Act as a biomarker and potential vaccine/antiviral target</p> Signup and view all the answers

    What is the potential role of minor nucleocapsid protein VP30 in Ebola virus?

    <p>Activates viral mRNA synthesis</p> Signup and view all the answers

    What is the function of VP40, the most abundant viral protein associated with the viral envelope?

    <p>Bridges envelope GP's to nucleocapsids</p> Signup and view all the answers

    What may aid in restoring endothelial barrier function according to the text?

    <p>A combination of inactivated neutrophils and reduced levels of pro-inflammatory cytokines</p> Signup and view all the answers

    What does periodic spikes in EBOV antibodies occurring months after clinical resolution of symptoms suggest?

    <p>Latent infection and potential disease recrudescence</p> Signup and view all the answers

    What is the genome type of Ebola virus?

    <p>Negative-sense single-stranded RNA</p> Signup and view all the answers

    Where does Ebola virus replication occur?

    <p>Cytoplasm</p> Signup and view all the answers

    Which cellular receptors does Ebola virus glycoprotein (GP) mediate binding to?

    <p>Integrin</p> Signup and view all the answers

    What is the lethality rate of Ebola virus?

    <p>90%</p> Signup and view all the answers

    Which viral proteins are packaged in the Ebola virus virion?

    <p>$VP35$ and $VP24$</p> Signup and view all the answers

    Study Notes

    Ebola Virus Replication and Glycoprotein Synthesis

    • Ebola virus lethality can be as high as 90%
    • Filovirus infections among humans are limited to close contacts, such as family members and medical staff
    • Ebola virus has a linear, negative sense, single-stranded RNA genome with seven genes
    • Most Ebola virus proteins are packaged in the virion, including nucleocapsid protein (NP), RNA polymerase cofactor (VP35), and envelope glycoproteins (GP, GP1, GP2)
    • Ebola virus makes additional secreted glycoproteins (sGP, delta-peptide)
    • Ebola virus has mRNA editing, whereas Marburg virus does not
    • Ebola virus replication occurs in the cytoplasm and involves the synthesis of antigenome RNA
    • The cytoplasm of infected cells contains inclusion bodies containing viral nucleocapsid
    • Ebola virus uses RNA editing to make two glycoproteins from the same gene: sGP and GP
    • Ebola virus glycoprotein (GP) mediates attachment and entry into host cells by fusion
    • GP mediates binding to multiple cellular receptors, including asialoglycoprotein receptor, folate receptor-alpha, integrin, and DC-Signs
    • Replication-deficient pseudotypes are used to study which viral proteins bind to which cellular receptors

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    Description

    Test your knowledge about the Marburg virus with this quiz covering its characteristics and historical outbreaks.

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