Podcast
Questions and Answers
What is the approximate genome size of the helical nucleocapsids with negative sense ssRNA?
What is the approximate genome size of the helical nucleocapsids with negative sense ssRNA?
- ~5-8kb
- ~10-12kb
- ~20-25kb
- ~15-19kb (correct)
Where was the first outbreak of Marburg virus?
Where was the first outbreak of Marburg virus?
- London and Paris
- Marburg and Frankfurt, Germany (correct)
- Caire and Sudan
- New York and Los Angeles
Which species of Ebolavirus is the most fatal type?
Which species of Ebolavirus is the most fatal type?
- Bundibugyo EBOV
- Sudan EBOV
- Zaire EBOV (correct)
- Reston EBOV
What is the likely source of transmission of Marburg and Ebola viruses to primates?
What is the likely source of transmission of Marburg and Ebola viruses to primates?
What is the function of sGP, a protein released from infected cells?
What is the function of sGP, a protein released from infected cells?
What is the potential role of minor nucleocapsid protein VP30 in Ebola virus?
What is the potential role of minor nucleocapsid protein VP30 in Ebola virus?
What is the function of VP40, the most abundant viral protein associated with the viral envelope?
What is the function of VP40, the most abundant viral protein associated with the viral envelope?
What may aid in restoring endothelial barrier function according to the text?
What may aid in restoring endothelial barrier function according to the text?
What does periodic spikes in EBOV antibodies occurring months after clinical resolution of symptoms suggest?
What does periodic spikes in EBOV antibodies occurring months after clinical resolution of symptoms suggest?
What is the genome type of Ebola virus?
What is the genome type of Ebola virus?
Where does Ebola virus replication occur?
Where does Ebola virus replication occur?
Which cellular receptors does Ebola virus glycoprotein (GP) mediate binding to?
Which cellular receptors does Ebola virus glycoprotein (GP) mediate binding to?
What is the lethality rate of Ebola virus?
What is the lethality rate of Ebola virus?
Which viral proteins are packaged in the Ebola virus virion?
Which viral proteins are packaged in the Ebola virus virion?
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Study Notes
Ebola Virus Replication and Glycoprotein Synthesis
- Ebola virus lethality can be as high as 90%
- Filovirus infections among humans are limited to close contacts, such as family members and medical staff
- Ebola virus has a linear, negative sense, single-stranded RNA genome with seven genes
- Most Ebola virus proteins are packaged in the virion, including nucleocapsid protein (NP), RNA polymerase cofactor (VP35), and envelope glycoproteins (GP, GP1, GP2)
- Ebola virus makes additional secreted glycoproteins (sGP, delta-peptide)
- Ebola virus has mRNA editing, whereas Marburg virus does not
- Ebola virus replication occurs in the cytoplasm and involves the synthesis of antigenome RNA
- The cytoplasm of infected cells contains inclusion bodies containing viral nucleocapsid
- Ebola virus uses RNA editing to make two glycoproteins from the same gene: sGP and GP
- Ebola virus glycoprotein (GP) mediates attachment and entry into host cells by fusion
- GP mediates binding to multiple cellular receptors, including asialoglycoprotein receptor, folate receptor-alpha, integrin, and DC-Signs
- Replication-deficient pseudotypes are used to study which viral proteins bind to which cellular receptors
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