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Marburg Virus Quiz

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Questions and Answers

What is the approximate genome size of the helical nucleocapsids with negative sense ssRNA?

~5-8kb

~10-12kb

~20-25kb

~15-19kb (correct)

Where was the first outbreak of Marburg virus?

London and Paris

Marburg and Frankfurt, Germany (correct)

Caire and Sudan

New York and Los Angeles

Which species of Ebolavirus is the most fatal type?

Bundibugyo EBOV

Sudan EBOV

Zaire EBOV (correct)

Reston EBOV

What is the likely source of transmission of Marburg and Ebola viruses to primates?

Fruit bats (zoonotic spread) Signup and view all the answers

What is the function of sGP, a protein released from infected cells?

Act as a biomarker and potential vaccine/antiviral target Signup and view all the answers

What is the potential role of minor nucleocapsid protein VP30 in Ebola virus?

Activates viral mRNA synthesis Signup and view all the answers

What is the function of VP40, the most abundant viral protein associated with the viral envelope?

Bridges envelope GP's to nucleocapsids Signup and view all the answers

What may aid in restoring endothelial barrier function according to the text?

A combination of inactivated neutrophils and reduced levels of pro-inflammatory cytokines Signup and view all the answers

What does periodic spikes in EBOV antibodies occurring months after clinical resolution of symptoms suggest?

Latent infection and potential disease recrudescence Signup and view all the answers

What is the genome type of Ebola virus?

Negative-sense single-stranded RNA Signup and view all the answers

Where does Ebola virus replication occur?

Cytoplasm Signup and view all the answers

Which cellular receptors does Ebola virus glycoprotein (GP) mediate binding to?

Integrin Signup and view all the answers

What is the lethality rate of Ebola virus?

90% Signup and view all the answers

Which viral proteins are packaged in the Ebola virus virion?

$VP35$ and $VP24$ Signup and view all the answers

Study Notes

Ebola Virus Replication and Glycoprotein Synthesis

Ebola virus lethality can be as high as 90%
Filovirus infections among humans are limited to close contacts, such as family members and medical staff
Ebola virus has a linear, negative sense, single-stranded RNA genome with seven genes
Most Ebola virus proteins are packaged in the virion, including nucleocapsid protein (NP), RNA polymerase cofactor (VP35), and envelope glycoproteins (GP, GP1, GP2)
Ebola virus makes additional secreted glycoproteins (sGP, delta-peptide)
Ebola virus has mRNA editing, whereas Marburg virus does not
Ebola virus replication occurs in the cytoplasm and involves the synthesis of antigenome RNA
The cytoplasm of infected cells contains inclusion bodies containing viral nucleocapsid
Ebola virus uses RNA editing to make two glycoproteins from the same gene: sGP and GP
Ebola virus glycoprotein (GP) mediates attachment and entry into host cells by fusion
GP mediates binding to multiple cellular receptors, including asialoglycoprotein receptor, folate receptor-alpha, integrin, and DC-Signs
Replication-deficient pseudotypes are used to study which viral proteins bind to which cellular receptors