Marburg Virus Characteristics and Outbreaks

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Questions and Answers

What is the approximate genome size of the helical nucleocapsids with negative sense ssRNA genome?

10-15kb (correct)

5-8kb

20-25kb

30-35kb

Where was the first outbreak of Marburg virus?

New York, USA

Caire and Sudan

London, UK

Marburg and Frankfurt, Germany (correct)

Which type of EBOV is considered the most fatal?

Sudan EBOV

Reston EBOV

Zaire EBOV (correct)

Bundibugyo EBOV

What is the probable source of transmission for Marburg and Ebola viruses to primates?

Fruit bats (zoonotic spread) Signup and view all the answers

What is the potential function of sGP (soluble glycoprotein) in Ebola virus infection?

Act as a decoy antigen Signup and view all the answers

What is the role of minor nucleocapsid protein VP30 in Ebola virus infection?

Activates viral mRNA synthesis Signup and view all the answers

Where is VP40, the most abundant viral protein in Ebola virus, located?

Cytoplasmic side of plasma membrane and/or inner side of viral envelope Signup and view all the answers

What does the observation of periodic spikes in EBOV antibodies in survivors suggest?

Latent infection and potential disease recrudescence Signup and view all the answers

Why do researchers use different viruses instead of the specific virus when generating pseudotypes?

Due to safety concerns Signup and view all the answers

What is the proposed function of sGP (soluble glycoprotein) in Ebola virus infection?

Reduce the production of pro-inflammatory cytokines Signup and view all the answers

What is the composition of Ebola virus genome?

Single-stranded RNA Signup and view all the answers

Where does Ebola virus replication occur?

Cytoplasm Signup and view all the answers

What is the lethality rate of Ebola virus?

90% Signup and view all the answers

Which proteins are packaged in the Ebola virus virion?

$NP, VP35, GP, GP1, GP2$ Signup and view all the answers

What is the function of Ebola virus glycoprotein (GP)?

$Mediates attachment and entry into host cells by fusion$ Signup and view all the answers

What is the role of mRNA editing in Ebola virus?

$To produce additional secreted glycoproteins (sGP, delta-peptide)$ Signup and view all the answers

What cellular receptors does Ebola virus glycoprotein (GP) bind to?

$Folate receptor-alpha$ Signup and view all the answers

What type of infections are Filovirus infections among humans limited to?

$Close contacts, such as family members and medical staff$ Signup and view all the answers

What is contained in the inclusion bodies in the cytoplasm of infected cells?

$Viral nucleocapsid$ Signup and view all the answers

What is used to study which viral proteins bind to which cellular receptors?

$Proteomics$ Signup and view all the answers

Study Notes

Ebola Virus Replication and Glycoprotein Synthesis

Ebola virus lethality can be as high as 90%
Filovirus infections among humans are limited to close contacts, such as family members and medical staff
Ebola virus has a linear, negative sense, single-stranded RNA genome with seven genes
Most Ebola virus proteins are packaged in the virion, including nucleocapsid protein (NP), RNA polymerase cofactor (VP35), and envelope glycoproteins (GP, GP1, GP2)
Ebola virus makes additional secreted glycoproteins (sGP, delta-peptide)
Ebola virus has mRNA editing, whereas Marburg virus does not
Ebola virus replication occurs in the cytoplasm and involves the synthesis of antigenome RNA
The cytoplasm of infected cells contains inclusion bodies containing viral nucleocapsid
Ebola virus uses RNA editing to make two glycoproteins from the same gene: sGP and GP
Ebola virus glycoprotein (GP) mediates attachment and entry into host cells by fusion
GP mediates binding to multiple cellular receptors, including asialoglycoprotein receptor, folate receptor-alpha, integrin, and DC-Signs
Replication-deficient pseudotypes are used to study which viral proteins bind to which cellular receptors

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Description

Test your knowledge of Marburg virus characteristics and outbreaks with this quiz covering filum, filamentous particles, genome size, and historical outbreaks in Germany, Egypt, and Sudan.