Podcast
Questions and Answers
What is the approximate genome size of the helical nucleocapsids with negative sense ssRNA genome?
What is the approximate genome size of the helical nucleocapsids with negative sense ssRNA genome?
- 10-15kb (correct)
- 5-8kb
- 20-25kb
- 30-35kb
Where was the first outbreak of Marburg virus?
Where was the first outbreak of Marburg virus?
- New York, USA
- Caire and Sudan
- London, UK
- Marburg and Frankfurt, Germany (correct)
Which type of EBOV is considered the most fatal?
Which type of EBOV is considered the most fatal?
- Sudan EBOV
- Reston EBOV
- Zaire EBOV (correct)
- Bundibugyo EBOV
What is the probable source of transmission for Marburg and Ebola viruses to primates?
What is the probable source of transmission for Marburg and Ebola viruses to primates?
What is the potential function of sGP (soluble glycoprotein) in Ebola virus infection?
What is the potential function of sGP (soluble glycoprotein) in Ebola virus infection?
What is the role of minor nucleocapsid protein VP30 in Ebola virus infection?
What is the role of minor nucleocapsid protein VP30 in Ebola virus infection?
Where is VP40, the most abundant viral protein in Ebola virus, located?
Where is VP40, the most abundant viral protein in Ebola virus, located?
What does the observation of periodic spikes in EBOV antibodies in survivors suggest?
What does the observation of periodic spikes in EBOV antibodies in survivors suggest?
Why do researchers use different viruses instead of the specific virus when generating pseudotypes?
Why do researchers use different viruses instead of the specific virus when generating pseudotypes?
What is the proposed function of sGP (soluble glycoprotein) in Ebola virus infection?
What is the proposed function of sGP (soluble glycoprotein) in Ebola virus infection?
What is the composition of Ebola virus genome?
What is the composition of Ebola virus genome?
Where does Ebola virus replication occur?
Where does Ebola virus replication occur?
What is the lethality rate of Ebola virus?
What is the lethality rate of Ebola virus?
Which proteins are packaged in the Ebola virus virion?
Which proteins are packaged in the Ebola virus virion?
What is the function of Ebola virus glycoprotein (GP)?
What is the function of Ebola virus glycoprotein (GP)?
What is the role of mRNA editing in Ebola virus?
What is the role of mRNA editing in Ebola virus?
What cellular receptors does Ebola virus glycoprotein (GP) bind to?
What cellular receptors does Ebola virus glycoprotein (GP) bind to?
What type of infections are Filovirus infections among humans limited to?
What type of infections are Filovirus infections among humans limited to?
What is contained in the inclusion bodies in the cytoplasm of infected cells?
What is contained in the inclusion bodies in the cytoplasm of infected cells?
What is used to study which viral proteins bind to which cellular receptors?
What is used to study which viral proteins bind to which cellular receptors?
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Study Notes
Ebola Virus Replication and Glycoprotein Synthesis
- Ebola virus lethality can be as high as 90%
- Filovirus infections among humans are limited to close contacts, such as family members and medical staff
- Ebola virus has a linear, negative sense, single-stranded RNA genome with seven genes
- Most Ebola virus proteins are packaged in the virion, including nucleocapsid protein (NP), RNA polymerase cofactor (VP35), and envelope glycoproteins (GP, GP1, GP2)
- Ebola virus makes additional secreted glycoproteins (sGP, delta-peptide)
- Ebola virus has mRNA editing, whereas Marburg virus does not
- Ebola virus replication occurs in the cytoplasm and involves the synthesis of antigenome RNA
- The cytoplasm of infected cells contains inclusion bodies containing viral nucleocapsid
- Ebola virus uses RNA editing to make two glycoproteins from the same gene: sGP and GP
- Ebola virus glycoprotein (GP) mediates attachment and entry into host cells by fusion
- GP mediates binding to multiple cellular receptors, including asialoglycoprotein receptor, folate receptor-alpha, integrin, and DC-Signs
- Replication-deficient pseudotypes are used to study which viral proteins bind to which cellular receptors
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