Podcast
Questions and Answers
What is the approximate genome size of the helical nucleocapsids with negative sense ssRNA genome?
What is the approximate genome size of the helical nucleocapsids with negative sense ssRNA genome?
Where was the first outbreak of Marburg virus?
Where was the first outbreak of Marburg virus?
What is the most fatal type of Ebolavirus?
What is the most fatal type of Ebolavirus?
How are Marburg and Ebola viruses likely transmitted to primates?
How are Marburg and Ebola viruses likely transmitted to primates?
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What is the Ebola virus genome composed of?
What is the Ebola virus genome composed of?
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Where does Ebola virus replication occur?
Where does Ebola virus replication occur?
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Which proteins are packaged in the Ebola virus virion?
Which proteins are packaged in the Ebola virus virion?
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What is the function of Ebola virus glycoprotein (GP)?
What is the function of Ebola virus glycoprotein (GP)?
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How does Ebola virus make two glycoproteins from the same gene?
How does Ebola virus make two glycoproteins from the same gene?
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What is the lethality rate of Ebola virus infections?
What is the lethality rate of Ebola virus infections?
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What is the function of sGP in Ebola virus infection?
What is the function of sGP in Ebola virus infection?
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What is the potential role of minor nucleocapsid protein VP30 in Ebola virus?
What is the potential role of minor nucleocapsid protein VP30 in Ebola virus?
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Where is VP40, the most abundant viral protein, located?
Where is VP40, the most abundant viral protein, located?
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What is observed in those who survive Ebola virus infection?
What is observed in those who survive Ebola virus infection?
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Why do scientists suggest vaccinating survivors of Ebola virus?
Why do scientists suggest vaccinating survivors of Ebola virus?
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What triggers outbreaks of disease recrudescence in survivors of Ebola virus?
What triggers outbreaks of disease recrudescence in survivors of Ebola virus?
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What does disrupting the stem-loop structure at the beginning of the NP gene lead to?
What does disrupting the stem-loop structure at the beginning of the NP gene lead to?
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Study Notes
Ebola Virus Replication and Glycoprotein Synthesis
- Ebola virus lethality can be as high as 90%
- Filovirus infections among humans are limited to close contacts, such as family members and medical staff
- Ebola virus has a linear, negative sense, single-stranded RNA genome with seven genes
- Most Ebola virus proteins are packaged in the virion, including nucleocapsid protein (NP), RNA polymerase cofactor (VP35), and envelope glycoproteins (GP, GP1, GP2)
- Ebola virus makes additional secreted glycoproteins (sGP, delta-peptide)
- Ebola virus has mRNA editing, whereas Marburg virus does not
- Ebola virus replication occurs in the cytoplasm and involves the synthesis of antigenome RNA
- The cytoplasm of infected cells contains inclusion bodies containing viral nucleocapsid
- Ebola virus uses RNA editing to make two glycoproteins from the same gene: sGP and GP
- Ebola virus glycoprotein (GP) mediates attachment and entry into host cells by fusion
- GP mediates binding to multiple cellular receptors, including asialoglycoprotein receptor, folate receptor-alpha, integrin, and DC-Signs
- Replication-deficient pseudotypes are used to study which viral proteins bind to which cellular receptors
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Description
Test your knowledge on viral filamentous particles and the outbreaks of the Marburg virus. Learn about the characteristics and historical events related to these infectious agents.
