Marburg Virus Quiz
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Questions and Answers

What is the approximate genome size of the helical nucleocapsids with negative sense ssRNA genome?

  • 20-25kb
  • 15-19kb (correct)
  • 5-8kb
  • 10-14kb

    • Where was the first outbreak of Marburg virus reported?

  • Victoria, Australia
  • Zaire
  • Marburg and Frankfurt, Germany (correct)
  • Caire and Sudan

    • Which species of Ebolavirus is named after its original site of discovery?

  • Victoria EBOV
  • Zaire EBOV (correct)
  • Sudan EBOV
  • Caire EBOV

    • What is the probable source of transmission for Marburg and Ebola viruses to primates?

    <p>Fruit bats (zoonotic spread)</p> Signup and view all the answers

    What is the potential function of sGP (soluble glycoprotein) in Ebola virus infection?

    <p>Act as a decoy antigen</p> Signup and view all the answers

    Which protein is associated with the viral envelope of Ebola virus?

    <p>VP40</p> Signup and view all the answers

    What is the potential role of VP30 in Ebola virus infection?

    <p>Activates viral mRNA synthesis</p> Signup and view all the answers

    Why do scientists suggest vaccinating survivors of Ebola virus?

    <p>To boost protective antibody responses in survivors</p> Signup and view all the answers

    Why is using different viruses instead of the specific virus in pseudotyping problematic?

    <p>Results may not be accurate for other viruses</p> Signup and view all the answers

    What is the mechanism by which VP40 facilitates virion formation at the plasma membrane?

    <p>It interacts with cellular proteins involved in intracellular vesicle trafficking and sorting</p> Signup and view all the answers

    What is the potential function of sGP as a soluble factor in Ebola virus infection?

    <p>It prevents activation of neutrophils</p> Signup and view all the answers

    What is the potential role of minor nucleocapsid protein VP30 in Ebola virus infection?

    <p>It activates viral mRNA synthesis by reversing inhibition caused by a stem-loop structure at the beginning of the NP gene</p> Signup and view all the answers

    What is the primary site of Ebola virus replication?

    <p>Cytoplasm</p> Signup and view all the answers

    Which cellular receptors does Ebola virus glycoprotein (GP) mediate binding to?

    <p>Integrin</p> Signup and view all the answers

    What is the function of sGP (soluble glycoprotein) in Ebola virus infection?

    <p>Inhibits host immune response</p> Signup and view all the answers

    What is the approximate lethality rate of Ebola virus?

    <p>90%</p> Signup and view all the answers

    Which type of RNA genome does Ebola virus possess?

    <p>$ssRNA$</p> Signup and view all the answers

    What is the role of VP35 in Ebola virus infection?

    <p>Viral genome replication</p> Signup and view all the answers

    Where are most Ebola virus proteins packaged within the virion?

    <p>Cytoplasm</p> Signup and view all the answers

    What is the potential role of minor nucleocapsid protein VP30 in Ebola virus infection?

    <p>Viral particle assembly</p> Signup and view all the answers

    What is the function of delta-peptide in Ebola virus infection?

    <p>Enhances viral genome replication</p> Signup and view all the answers

    How do scientists study which viral proteins bind to which cellular receptors?

    <p>Using pseudotyped viruses with different cellular receptors</p> Signup and view all the answers

    What type of RNA editing does Ebola virus utilize for glycoprotein synthesis?

    <p>mRNA editing</p> Signup and view all the answers

    Where are inclusion bodies containing viral nucleocapsid found during Ebola virus infection?

    <p>Cytoplasm</p> Signup and view all the answers

    Study Notes

    Ebola Virus Replication and Glycoprotein Synthesis

    • Ebola virus lethality can be as high as 90%
    • Filovirus infections among humans are limited to close contacts, such as family members and medical staff
    • Ebola virus has a linear, negative sense, single-stranded RNA genome with seven genes
    • Most Ebola virus proteins are packaged in the virion, including nucleocapsid protein (NP), RNA polymerase cofactor (VP35), and envelope glycoproteins (GP, GP1, GP2)
    • Ebola virus makes additional secreted glycoproteins (sGP, delta-peptide)
    • Ebola virus has mRNA editing, whereas Marburg virus does not
    • Ebola virus replication occurs in the cytoplasm and involves the synthesis of antigenome RNA
    • The cytoplasm of infected cells contains inclusion bodies containing viral nucleocapsid
    • Ebola virus uses RNA editing to make two glycoproteins from the same gene: sGP and GP
    • Ebola virus glycoprotein (GP) mediates attachment and entry into host cells by fusion
    • GP mediates binding to multiple cellular receptors, including asialoglycoprotein receptor, folate receptor-alpha, integrin, and DC-Signs
    • Replication-deficient pseudotypes are used to study which viral proteins bind to which cellular receptors

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    Test your knowledge on the characteristics and history of the Marburg virus, including its genome size, outbreak history, and impact on infected individuals.

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