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Questions and Answers
What is the approximate genome size of the helical nucleocapsids with negative sense ssRNA genome?
Where was the first outbreak of Marburg virus reported?
Which species of Ebolavirus is named after its original site of discovery?
What is the probable source of transmission for Marburg and Ebola viruses to primates?
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What is the potential function of sGP (soluble glycoprotein) in Ebola virus infection?
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Which protein is associated with the viral envelope of Ebola virus?
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What is the potential role of VP30 in Ebola virus infection?
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Why do scientists suggest vaccinating survivors of Ebola virus?
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Why is using different viruses instead of the specific virus in pseudotyping problematic?
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What is the mechanism by which VP40 facilitates virion formation at the plasma membrane?
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What is the potential function of sGP as a soluble factor in Ebola virus infection?
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What is the potential role of minor nucleocapsid protein VP30 in Ebola virus infection?
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What is the primary site of Ebola virus replication?
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Which cellular receptors does Ebola virus glycoprotein (GP) mediate binding to?
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What is the function of sGP (soluble glycoprotein) in Ebola virus infection?
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What is the approximate lethality rate of Ebola virus?
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Which type of RNA genome does Ebola virus possess?
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What is the role of VP35 in Ebola virus infection?
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Where are most Ebola virus proteins packaged within the virion?
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What is the potential role of minor nucleocapsid protein VP30 in Ebola virus infection?
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What is the function of delta-peptide in Ebola virus infection?
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How do scientists study which viral proteins bind to which cellular receptors?
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What type of RNA editing does Ebola virus utilize for glycoprotein synthesis?
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Where are inclusion bodies containing viral nucleocapsid found during Ebola virus infection?
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Study Notes
Ebola Virus Replication and Glycoprotein Synthesis
- Ebola virus lethality can be as high as 90%
- Filovirus infections among humans are limited to close contacts, such as family members and medical staff
- Ebola virus has a linear, negative sense, single-stranded RNA genome with seven genes
- Most Ebola virus proteins are packaged in the virion, including nucleocapsid protein (NP), RNA polymerase cofactor (VP35), and envelope glycoproteins (GP, GP1, GP2)
- Ebola virus makes additional secreted glycoproteins (sGP, delta-peptide)
- Ebola virus has mRNA editing, whereas Marburg virus does not
- Ebola virus replication occurs in the cytoplasm and involves the synthesis of antigenome RNA
- The cytoplasm of infected cells contains inclusion bodies containing viral nucleocapsid
- Ebola virus uses RNA editing to make two glycoproteins from the same gene: sGP and GP
- Ebola virus glycoprotein (GP) mediates attachment and entry into host cells by fusion
- GP mediates binding to multiple cellular receptors, including asialoglycoprotein receptor, folate receptor-alpha, integrin, and DC-Signs
- Replication-deficient pseudotypes are used to study which viral proteins bind to which cellular receptors
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Description
Test your knowledge on the characteristics and history of the Marburg virus, including its genome size, outbreak history, and impact on infected individuals.
