6 Questions
What DNA secondary structures are exploited by the malaria parasite in immune evasion?
DNA hairpins
What genomic features are involved in the formation of CNVs in the malaria parasite?
Long monomeric A/T tracks and DNA hairpins
How can targeting DNA repair pathways be exploited to break the adaption of the parasite upon exposure to drugs?
Targeting DNA repair pathways can be exploited to break the adaption of the parasite upon exposure to drugs by disrupting the formation of CNVs.
What role do long monomeric A/T tracks play in the formation of resistance causing CNVs in the malaria parasite?
They are present on the breakpoints of several resistance causing CNVs and work in cooperation with DNA hairpins to start CNV development.
How do DNA hairpins and A/T tracks contribute to CNV formation in the malaria parasite's genome?
DNA hairpins found near long A/T tracks have the propensity to generate double-stranded breaks caused by replication fork collapse or breakdown by hairpin-binding proteins, initiating CNV formation.
How can the molecular pathways leading to CNV formation in the malaria parasite be targeted to disrupt its adaption upon exposure to drugs?
Targeting DNA repair pathways can be exploited to break the adaption of the parasite upon exposure to drugs.
Explore the molecular pathways and DNA secondary structures exploited by the malaria parasite in immune evasion. Learn about the mechanism of CNV formation in the parasite and the potential DNA sequence features triggering CNV formation and selection.
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