Malaria Parasite DNA Structures and CNV Formation Mechanism
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Questions and Answers

What DNA secondary structures are exploited by the malaria parasite in immune evasion?

DNA hairpins

What genomic features are involved in the formation of CNVs in the malaria parasite?

Long monomeric A/T tracks and DNA hairpins

How can targeting DNA repair pathways be exploited to break the adaption of the parasite upon exposure to drugs?

Targeting DNA repair pathways can be exploited to break the adaption of the parasite upon exposure to drugs by disrupting the formation of CNVs.

What role do long monomeric A/T tracks play in the formation of resistance causing CNVs in the malaria parasite?

<p>They are present on the breakpoints of several resistance causing CNVs and work in cooperation with DNA hairpins to start CNV development.</p> Signup and view all the answers

How do DNA hairpins and A/T tracks contribute to CNV formation in the malaria parasite's genome?

<p>DNA hairpins found near long A/T tracks have the propensity to generate double-stranded breaks caused by replication fork collapse or breakdown by hairpin-binding proteins, initiating CNV formation.</p> Signup and view all the answers

How can the molecular pathways leading to CNV formation in the malaria parasite be targeted to disrupt its adaption upon exposure to drugs?

<p>Targeting DNA repair pathways can be exploited to break the adaption of the parasite upon exposure to drugs.</p> Signup and view all the answers

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