3 Questions
What is the function of the integral membrane protein complexes on cell surfaces?
Recognizing antigens for lymphocytes
Where are MHC molecules made?
Rough ER and Golgi apparatus
What is the role of MHC class I and class II molecules?
Presenting antigens to lymphocytes
Study Notes
Integral Membrane Protein Complexes on Cell Surfaces
- Integral membrane protein complexes on cell surfaces play a crucial role in antigen presentation, enabling the immune system to recognize and respond to pathogens.
MHC Molecule Production
- MHC molecules are produced in the endoplasmic reticulum (ER) of cells.
MHC Class I and Class II Molecules
- MHC class I molecules are responsible for presenting endogenous antigens (from inside the cell) to CD8+ T cells, which then recognize and eliminate infected cells.
- MHC class II molecules, on the other hand, present exogenous antigens (from outside the cell) to CD4+ T cells, which activate other immune cells to respond to the pathogen.
Test your knowledge of the major histocompatibility complex (MHC) and its role in presenting antigens to lymphocytes. Explore the structure and function of MHC class I and class II molecules, and their synthesis in the rough endoplasmic reticulum (ER) and Golgi apparatus.
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