Liver Phosphorylase and Glucose Production Quiz
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Questions and Answers

Which factor deactivates liver phosphorylase enzyme?

  • Insulin
  • Glucose (correct)
  • Epinephrine
  • Glucagon
  • What effect do hormones that increase cAMP levels have on the activation of glycogen phosphorylase?

  • Promote activation (correct)
  • Inhibit activation
  • Delay activation
  • Have no effect
  • How does insulin affect the activity of phosphoprotein phosphatase in relation to phosphorylase?

  • Inhibits activation
  • Delays activation
  • Promotes activation (correct)
  • Has no effect
  • Under what conditions does glucagon stimulate liver glycogen breakdown?

    <p>Low blood glucose</p> Signup and view all the answers

    Which hormone enhances glycogen breakdown in both muscle and liver for muscle contraction?

    <p>Epinephrine</p> Signup and view all the answers

    Which process dominates in the liver during fasting?

    <p>Glycogenolysis</p> Signup and view all the answers

    What is the effect of high concentrations of ATP on muscle phosphorylase activity?

    <p>Allosteric inhibition</p> Signup and view all the answers

    Which hormone activates phosphorylase a in skeletal muscle?

    <p>Epinephrine</p> Signup and view all the answers

    What is the primary function of muscle phosphorylase in its 'a' form?

    <p>Catalytically active</p> Signup and view all the answers

    Which compound is converted to glucose 6-phosphate in skeletal muscle?

    <p>Glucose 1-phosphate</p> Signup and view all the answers

    In skeletal muscle, what regulates glycogen degradation in response to ATP needs?

    <p>ATP and AMP levels</p> Signup and view all the answers

    Which molecule activates glycogen phosphorylase in the glucagon/epinephrine signaling pathway?

    <p>cAMP</p> Signup and view all the answers

    In resting muscle, which form is predominantly inactive?

    <p>b form</p> Signup and view all the answers

    What is the end product generated by glucose-6-phosphate entering the glycolytic pathway?

    <p>ATP</p> Signup and view all the answers

    Which molecule acts as a feedback inhibitor of glycogen phosphorylase?

    <p>ATP</p> Signup and view all the answers

    What provides a direct and rapid means of stimulating glycogen degradation during muscle contraction?

    <p>Ca released from sarcoplasmic reticulum</p> Signup and view all the answers

    Glycogen phosphorylase generates which molecule that is isomerized into glucose-6-phosphate?

    <p>Glucose-1-phosphate</p> Signup and view all the answers

    How does insulin stimulate glycogen synthesis?

    <p>By inactivating GSK-3 and activating glycogen synthase</p> Signup and view all the answers

    What is the role of Protein Phosphatase 1 (PP1) in glycogen metabolism?

    <p>Removes phosphoryl groups from glycogen synthase b</p> Signup and view all the answers

    How do myocytes contribute to lowering blood glucose in response to insulin?

    <p>By moving GLUT4 to the plasma membrane for increased glucose uptake</p> Signup and view all the answers

    What effect does elevated insulin have on glycogen synthesis in myocytes?

    <p>Activates PP1 and inactivates GSK3</p> Signup and view all the answers

    What is the consequence of removing phosphoryl groups from glycogen synthase b by PP1?

    <p>Conversion to the active glycogen synthase a form</p> Signup and view all the answers

    How are cAMP cascades involved in regulating glycogen metabolism?

    <p>They shut off glycogen synthesis</p> Signup and view all the answers

    What effect does glucagon have on muscle glycogen levels?

    <p>Has no effect on muscle glycogen levels</p> Signup and view all the answers

    What is the role of AMP in muscle glycogen phosphorylase activation?

    <p>Serves as an allosteric activator of muscle glycogen phosphorylase</p> Signup and view all the answers

    From where do the effects of Ca in muscle primarily result?

    <p>Release of Ca from the sarcoplasmic reticulum after neural stimulation</p> Signup and view all the answers

    How does epinephrine-stimulated phosphorylation affect skeletal muscle glycogen?

    <p>Induces similar effects as in liver glycogen metabolism</p> Signup and view all the answers

    What role does covalent modification play in the regulation of glycogen synthase?

    <p>Converts active form into inactive form</p> Signup and view all the answers

    How is glycogen synthase regulated by ATP and glucose-6-P?

    <p>Stimulated by ATP and glucose-6-P</p> Signup and view all the answers

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