Lipopolysaccharide and Cytokines Quiz
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Questions and Answers

What mechanism is responsible for the diffuse white plaques in the oral cavity of the 1-month-old male?

  • Deficiency of CD40 ligand on T cells
  • Enhanced T lymphocyte activity
  • Increased CD40 ligand expression
  • Decreased B lymphocyte activity (correct)
  • In a 8-month-old with super high IgM levels on a lab report, what mechanism is likely involved?

  • Enhanced T lymphocyte activity
  • Normal B cell function
  • Deficiency of CD40 receptor on B cells (correct)
  • Overexpression of CD40 ligand on T cells
  • What is the likely diagnosis for a 6-year-old female with recurrent Staph abscesses, eczematoid skin lesions, and abnormal dentition?

  • Common variable immunodeficiency (CVID)
  • Wiskott-Aldrich syndrome
  • Hyper IgE syndrome (Job syndrome) (correct)
  • Ataxia-telangiectasia
  • What cell dysfunction is responsible for eczematoid skin lesions and thrombocytopenia in a 12-month-old male with history of infections?

    <p>T cell</p> Signup and view all the answers

    In a 3-year-old female with dilated superficial blood vessels on the face and a wobbly gait, what mechanism is likely at play?

    <p>Failure of double-stranded DNA break repair</p> Signup and view all the answers

    What is the likely diagnosis for a 17-month-old male presenting with lymphadenopathy, fever, hepatosplenomegaly, low RBCs and WBCs, and high IgM and IgG levels?

    <p>Common variable immunodeficiency (CVID)</p> Signup and view all the answers

    What is a common drug associated with agranulocytosis, often indicated by mouth ulcers, sore throat, and fever?

    <p>Ganciclovir</p> Signup and view all the answers

    In which type of hypersensitivity reaction does cryoglobulinemia play a role, causing skin lesions, Raynaud phenomenon, muscle pain, and glomerulonephritis?

    <p>Type III</p> Signup and view all the answers

    In hyper-IgM syndrome, what biological property is associated with the predominant immunoglobulin in the serum of affected patients?

    <p>Complement activation</p> Signup and view all the answers

    Which of the following is NOT a common symptom associated with cryoglobulinemia?

    <p>Joint swelling</p> Signup and view all the answers

    What is the mechanism of action of thionamides in causing neutropenia?

    <p>Inhibition of DNA synthesis</p> Signup and view all the answers

    Which patient characteristic is associated with hyper-IgM syndrome?

    <p>Defective CD40 ligand expression on B cells</p> Signup and view all the answers

    What is the mechanism by which lipid A of lipopolysaccharide (LPS) in gram (-) sepsis stimulates macrophages?

    <p>Interacting with toll-like receptor 4 (CD14 co-receptor)</p> Signup and view all the answers

    Which cytokine is responsible for causing fever in response to lipopolysaccharide (LPS) exposure?

    <p>IL-1</p> Signup and view all the answers

    What is the role of toll-like receptor 4 (CD14 co-receptor) in the immune response to endotoxin exposure?

    <p>Stimulating cytokine release</p> Signup and view all the answers

    In a patient presenting with toxic shock syndrome, which immunological receptors are primarily involved?

    <p>MHC II and TCR</p> Signup and view all the answers

    How can a patient with phenylketonuria (PKU) be identified shortly after birth to prevent complications?

    <p>Routine heel-prick test for newborn screening</p> Signup and view all the answers

    What is the key enzyme deficiency in phenylketonuria (PKU) that leads to the need for dietary restrictions?

    <p>Phenylalanine hydroxylase</p> Signup and view all the answers

    What is the mechanism behind the development of Hemolytic disease of the newborn (Rh type)?

    <p>Fetal blood containing Rh antigen crosses the placenta and sensitizes the mother's immune system to produce anti-Rh antibodies.</p> Signup and view all the answers

    Which antibody type is predominantly present in individuals with opposing blood types, except for those with O blood?

    <p>IgM antibodies</p> Signup and view all the answers

    Which infectious association is commonly linked to a positive Coombs test due to IgM antibodies against RBCs?

    <p>Cytomegalovirus (CMV)</p> Signup and view all the answers

    How does molecular mimicry contribute to the pathogenesis of some autoimmune diseases?

    <p>It leads to the generation of autoantibodies due to similarities between foreign and self-antigens.</p> Signup and view all the answers

    Which antibody is involved in the hemolysis of fetal Rh(+) RBCs in Hemolytic disease of the newborn (Rh type)?

    <p>IgG</p> Signup and view all the answers

    Why can a fetus be symptomatic if a mother with O blood has a higher percentage of anti-A and -B antibodies that are IgG?

    <p>The elevated IgG antibodies cause hemolysis of fetal RBCs.</p> Signup and view all the answers

    What is the effect of p53 mutation in cancer invasion?

    <p>Defective DNA repair</p> Signup and view all the answers

    In a patient with cellulitis who develops fever, confusion, tachycardia, and low blood pressure, which two cytokines are likely responsible for the condition?

    <p>IL-1 and TNF-a</p> Signup and view all the answers

    Why would giving aspirin or ibuprofen decrease fever in a patient with sepsis?

    <p>Inhibiting IL-1 production</p> Signup and view all the answers

    What is responsible for the loss of appetite in a patient with breast cancer who has lost 20 lbs in the past month?

    <p>TNF-a-induced cachexia</p> Signup and view all the answers

    In a study comparing two cell lines, one with an IL-2 gene transfected and the other without, which type of cell is likely generating a stronger immune response?

    <p>T lymphocyte</p> Signup and view all the answers

    If a USMLE question focuses on sepsis and asks about the molecule responsible for changes in blood pressure, what would be the most likely correct answer?

    <p>TNF-a</p> Signup and view all the answers

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