10 Questions
What is the main function of endotoxin in Gram-negative bacteria?
Maintaining the organization and stability of the cell wall
What is the typical pyrogenic characteristic of endotoxin?
Inducing various biological reactions even in small amounts
What symptoms may be caused by the presence of endotoxin in the bloodstream?
Fever, hypotension, nausea, shivering, and shock
Why is it not possible to completely inactivate endotoxin with autoclaving?
Due to its heat resistance and stability
Where can endotoxin be found in the environment?
Water and air inhabited by Gram-negative bacteria
Which component of LPS is responsible for the bioactivity of LPS?
Lipid A
What is the role of LpxB in the lipid A biosynthesis pathway?
Responsible for the condensation of lipid X with UDP-2,3-diacylglucosamine
Which bacteria produce A-B toxins?
Clostridium tetani, Clostridium diphtheria, Vibrio cholerae, Staph. aureus, Shigella flexneri
What is the main role of part A in A-B toxins?
Active enzymatic component altering the functions of host cells through inhibition of protein synthesis
What is the mechanism of action of Superantigens?
Bind to MHC class II molecules and T-cell receptor outside the antigen recognition site
Test your knowledge of endotoxin characteristics, its composition, and the biological reactions it induces when entering the bloodstream. Explore the role of endotoxin as a complex lipopolysaccharide in the outer cell wall of Gram-negative bacteria.
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