Lincosamides in Veterinary Medicine
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Questions and Answers

Why are lincosamides generally ineffective against facultative anaerobic gram-negative bacteria?

  • They exhibit increased bacterial load
  • They have impermeability and methylation of the ribosomal binding site (correct)
  • They have enhanced activity at an alkaline pH
  • They lack ribosomal binding sites

    • In which form are lincosamides more stable?

  • Hydroxide form
  • Sulfate form
  • Salt forms (hydrochlorides and phosphates) (correct)
  • Monobasic form

    • Which type of infections are lincosamides indicated for?

  • Gram-positive infections (correct)
  • Fungal infections
  • Gram-negative infections
  • Viral infections

    • What is clindamycin approved for in cats and dogs?

    <p>Dental infections</p> Signup and view all the answers

    What serious adverse reaction can occur in certain species due to lincosamides?

    <p>Pseudomembranous enterocolitis</p> Signup and view all the answers

    What condition can result from administering clindamycin without food or water in cats?

    <p>Esophagitis and ulceration</p> Signup and view all the answers

    What effect do lincosamides have on the GI tract?

    <p>They may cause GI disturbances</p> Signup and view all the answers

    What is the recommended action if a patient with hepatic insufficiency requires lincosamide treatment?

    <p>Dose reduction should be considered</p> Signup and view all the answers

    What is the primary mechanism responsible for cross-resistance between macrolides and streptogramin group B?

    <p>Similarities in their mechanism of action</p> Signup and view all the answers

    What does MLSK resistance refer to?

    <p>Resistance to ketolides and streptogramin B</p> Signup and view all the answers

    What is the potential cross-resistance pattern in MLSB bacteria?

    <p>Development of rapid resistance to lincosamides after exposure to macrolides</p> Signup and view all the answers

    What should be done if isolates are resistant to macrolides but susceptible to clindamycin under standard testing?

    <p>Test for methylase mediated clindamycin resistance via the D-zone test</p> Signup and view all the answers

    Which organism shows regular resistance to clindamycin?

    <p>Clostridium difficile</p> Signup and view all the answers

    What is the reason for poor CSF concentrations of lincosamides?

    <p>Both high degree of plasma-protein binding and rapid elimination kinetics</p> Signup and view all the answers

    Where do lincosamides accumulate due to their basic nature?

    <p>Abscesses, the prostate, or the udder</p> Signup and view all the answers

    What is the primary excretory route for clindamycin?

    <p>Feces</p> Signup and view all the answers

    Where do lincosamides accumulate due to their basic nature?

    <p>Abscesses, the prostate, or the udder</p> Signup and view all the answers

    What is the primary excretory route for clindamycin?

    <p>Feces</p> Signup and view all the answers

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