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Leukemias and Their Classification

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Questions and Answers

What is the common origin of leukemias?

Clonal expansion of mature hematopoietic cells in the lymph nodes

Clonal expansion of normal hematopoietic cells in the bone marrow

Clonal expansion of malignant hematopoietic cells in the bone marrow (correct)

Clonal expansion of mature hematopoietic cells in the blood

Which of the following is a characteristic of Acute lymphoblastic leukemia (ALL)?

Common in children between 3-7 years old (correct)

Common in adults

Common in children above 10 years old

Common in children below 3 years old

What is a known environmental factor that increases the incidence of leukemias?

Excessive exercise

Prolonged exposure to sunlight

High dosage of vitamins

Exposure to chemicals such as benzene compounds (correct)

Which of the following is a genetic factor that increases the incidence of leukemias?

Down's syndrome Signup and view all the answers

What is the consequence of malignant transformation of an immature precursor cell?

Leukemia Signup and view all the answers

Which of the following viruses is associated with leukemia?

HTLV-I Signup and view all the answers

What is a characteristic of abnormal blast cells in leukemia?

They can proliferate, independently out of any control Signup and view all the answers

Why do leukemic cells accumulate in the bone marrow?

Because their structure and size don't allow them to leave the bone marrow Signup and view all the answers

What is a characteristic of acute leukemia?

It is a rapidly progressing disease, evolving within days to few weeks Signup and view all the answers

What happens to normal bone marrow in acute leukemia?

It is replaced by malignant blast cells Signup and view all the answers

Why can leukemic cells infiltrate any organ or site?

Because they are blood-borne cells Signup and view all the answers