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Questions and Answers
Acute Myeloid Leukemia is associated with mature cells.
Acute Myeloid Leukemia is associated with mature cells.
False
Which of the following are main classifications of leukemia?
Which of the following are main classifications of leukemia?
The term CLL refers to ___.
The term CLL refers to ___.
Chronic Lymphocytic Leukemia
What does ALL stand for?
What does ALL stand for?
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What is a characteristic of acute leukemia?
What is a characteristic of acute leukemia?
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Match the following types of Acute Myeloid Leukemias (AML) with their classifications:
Match the following types of Acute Myeloid Leukemias (AML) with their classifications:
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What are the two main classifications of leukemia?
What are the two main classifications of leukemia?
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Chronic Lymphocytic Leukemia (CLL) primarily affects children.
Chronic Lymphocytic Leukemia (CLL) primarily affects children.
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Acute Myeloid Leukemia (AML) has a sudden onset.
Acute Myeloid Leukemia (AML) has a sudden onset.
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Which of the following is NOT a classification of Acute Myeloid Leukemia (AML)?
Which of the following is NOT a classification of Acute Myeloid Leukemia (AML)?
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Match the types of leukemia with their characteristics:
Match the types of leukemia with their characteristics:
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What characterizes the age group affected by Acute Lymphoblastic Leukemia (ALL)?
What characterizes the age group affected by Acute Lymphoblastic Leukemia (ALL)?
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Study Notes
Cancer Cytogenetics
- Cancer is caused by multiple and sequential genetic mutations occurring in a somatic cell.
- Leukemia is the uncontrolled proliferation of one or more of the various hematopoietic cells.
- Leukemia is associated with many changes in the circulating cells of the blood.
Leukemia Classification
- There are two main classifications of leukemia: Lymphocytic and Myelocytic.
Lymphocytic Leukemia
- ALL (Acute Lymphoblastic Leukemia)
- CLL (Chronic Lymphocytic Leukemia)
Myelocytic Leukemia
- AML (Acute Myeloid Leukemia)
- CML (Chronic Myelogenous Leukemia)
Acute vs Chronic Leukemia
- Acute leukemia typically affects children and young adults.
- Chronic leukemia usually affects middle-aged and elderly individuals.
- Acute leukemia is characterized by a sudden onset, with a progression of weeks to months.
- Chronic leukemia has an insidious onset and progresses over years.
- Acute cases involve blast cells, whereas chronic cases consist of mature cells.
- AML is characterized by myeloblasts, while CML involves granulocytes.
- ALL is characterized by lymphoblasts, while CLL involves lymphocytes.
Acute Myeloid Leukemias (AML)
- AML is classified using the FAB (French-American-British) system.
- There are eight subtypes of AML:
- M0: Minimally differentiated
- M1: Myeloblastic leukemia without maturation
- M2: Myeloblastic leukemia with maturation
- M3: Hypergranular promyelocytic leukemia
- M4: Myelomonocytic leukemia
- M4Eo: Variant, increase in marrow eosinophils
- M5: Monocytic leukemia
- M6: Erythroleukemia
- M7: Megakaryoblastic leukemia
Acute Lymphoblastic Leukemia (ALL)
- There are various subtypes of ALL including L1.
Cancer
- Cancer is the uncontrolled proliferation of cells due to multiple and sequential genetic mutations occurring in a somatic cell.
Leukemia
- Leukemia is the uncontrolled proliferation of one or more hematopoietic cells.
Leukemia Classifications
- There are two main classifications of leukemia:
- Lymphocytic (ALL – Acute Lymphoblastic Leukemia, CLL – Chronic Lymphocytic Leukemia)
- Myelocytic (AML – Acute Myeloid Leukemia, CML – Chronic Myelogenous Leukemia)
Acute vs Chronic Leukemia
-
Acute Leukemia is characterized by:
- More common in children and young adults
- Sudden onset
- Rapid progression (weeks to months)
- Presence of blast cells (immature cells)
- Example: AML - myeloblasts, ALL - lymphoblasts
-
Chronic Leukemia is characterized by:
- More common in middle-aged and elderly individuals
- Insidious onset
- Slow progression (years)
- Presence of mature cells
- Example: CML – granulocytes, CLL – lymphocytes
Acute Myeloid Leukemia (AML) Classification
- M0: Minimally differentiated
- M1: Myeloblastic leukemia without maturation
- M2: Myeloblastic leukemia with maturation
- M3: Hypergranular promyelocytic leukemia
- M4: Myelomonocytic leukemia
- M4Eo: variant, increase in marrow eosinophils
- M5: Monocytic leukemia
- M6: Erythroleukemia
- M7: Megakaryoblastic leukemia
Acute Lymphoblastic Leukemia (ALL)
- L1 (The text does not provide more specifics, but it is assumed that L1 is a subtype of ALL and there will be a further breakdown)
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Description
This quiz covers the fundamentals of cancer cytogenetics, focusing on leukemia classification. It details the differences between lymphocytic and myelocytic leukemia, elaborating on acute and chronic types. Test your knowledge on the genetic factors associated with leukemia and its types.
