38 Questions
What is the primary use of lamotrigine in children aged 2 years and older?
Treatment of partial seizures
How does lamotrigine impact voltage-sensitive sodium channels?
Inhibits them
What is the mechanism of action of lamotrigine in bipolar disorder treatment?
Not known
Where does lamotrigine cross during pregnancy?
Placenta
When does immediate-release lamotrigine peak after oral administration?
2 hours
What percentage of lamotrigine is protein-bound?
55%
When prescribing lamotrigine, what is warranted?
Consultation with a neurologist
Which of the following should NOT be monitored when a patient is taking lamotrigine?
Cardiovascular health
How should patients take lamotrigine tablets?
Take them exactly as prescribed without crushing or chewing
What should patients do if they develop a rash while taking lamotrigine?
Report it to their provider immediately
Which of the following potential adverse drug reactions (ADRs) should patients and their families be warned about when taking lamotrigine?
Neuropsychiatric reactions, including suicidal thoughts and behavioral changes
What lifestyle management strategies are recommended for patients with seizures who are taking lamotrigine?
Get adequate sleep and exercise, avoid stressful situations
What is a concerning potential side effect associated with lamotrigine use?
Increased suicidal thoughts
How should lamotrigine be tapered off to avoid withdrawal seizures?
Tapered off over 2 weeks
Which of the following is a rare reaction associated with lamotrigine?
Aplastic anemia
What is the most concerning drug interaction with lamotrigine?
Increased risk of life-threatening rash when taken with valproate
How does lamotrigine interact with oral estrogen-containing contraceptives?
Decreases lamotrigine levels by approximately 50%
What is the initial dosing for patients aged 12 years and older who are not taking enzyme-inducing antiepileptic drugs (AEDs)?
$25 mg per day for 2 weeks
What does the concurrent administration of valproate with lamotrigine increase the risk of?
$200% increase in life-threatening rash development
How is dosing adjusted for children aged 2 to 12 years who are not taking enzyme-inducing AEDs?
$0.3 mg/kg per day for weeks 1 and 2
What should be avoided when prescribing regular or chewable tablets of lamotrigine?
$Crushing or chewing the tablets
Which of the following statements regarding lamotrigine metabolism is correct?
It is metabolized via glucuronic acid conjugation in the liver.
Which of the following is a contraindication for lamotrigine?
Hypersensitivity to the drug or its ingredients
Which of the following is a potential life-threatening adverse reaction associated with lamotrigine?
Disseminated intravascular coagulation
Which of the following statements regarding lamotrigine and rash is incorrect?
Pediatric patients are less likely to have serious rashes than adults.
Which of the following is a potential risk associated with lamotrigine use?
Suicidal thoughts and depression
Which of the following statements regarding lamotrigine withdrawal is correct?
Lamotrigine should be withdrawn slowly over at least 2 weeks.
Which of the following statements regarding lamotrigine and pregnancy is correct?
Lamotrigine decreased folate levels in animal studies.
Which of the following statements regarding lamotrigine and breastfeeding is incorrect?
Maternal lamotrigine levels remain constant during the postpartum period.
For which of the following conditions is lamotrigine FDA approved for use in children aged 2 years and older?
Lennox-Gastaut syndrome
Which of the following adverse reactions has a Black Box Warning associated with lamotrigine use?
Stevens-Johnson syndrome (SJS)
What is the usual maintenance dose of lamotrigine for pediatric patients aged 2 to 12 years who are not taking valproate?
1 to 5 mg/kg per day
What is the initial dose of lamotrigine in patients older than age 12 years who are taking valproate?
25 mg per day
How should the dose of lamotrigine be adjusted in children who weigh less than 30 kg?
Increased by as much as 50%
What is the dosage adjustment for lamotrigine in adult patients with bipolar disorder who are taking carbamazepine?
50 mg daily in weeks 3 and 4
In patients taking oral contraceptives along with lamotrigine, how is the lamotrigine dose altered?
Increased by 50% weekly
What is the dose of lamotrigine for pediatric patients aged 2 to 12 years taking valproate?
25 mg every other day for weeks 1 and 2
What should be noted about the escalation schedule of lamotrigine in patients taking valproate?
.It involves a slower escalation due to decreased clearance
Explore the clinical uses and pharmacodynamics of Lamotrigine (Lamictal) in the treatment of seizures and bipolar 1 disorder. Learn about its mechanism of action and approved indications for different age groups.
Make Your Own Quizzes and Flashcards
Convert your notes into interactive study material.
Get started for free
