Lamotrigine: Clinical Uses and Pharmacodynamics
38 Questions
0 Views

Choose a study mode

Play Quiz
Study Flashcards
Spaced Repetition
Chat to lesson

Podcast

Play an AI-generated podcast conversation about this lesson

Questions and Answers

What is the primary use of lamotrigine in children aged 2 years and older?

  • Prevention of febrile seizures
  • Treatment of partial seizures (correct)
  • Management of migraine headaches
  • Control of vertigo episodes

    • How does lamotrigine impact voltage-sensitive sodium channels?

  • Stabilizes them
  • Activates them
  • Inhibits them (correct)
  • Has no effect on them

    • What is the mechanism of action of lamotrigine in bipolar disorder treatment?

  • Blocks acetylcholine receptors
  • Increases dopamine levels
  • Not known (correct)
  • Inhibits serotonin reuptake

    • Where does lamotrigine cross during pregnancy?

    <p>Placenta</p> Signup and view all the answers

    When does immediate-release lamotrigine peak after oral administration?

    <p>2 hours</p> Signup and view all the answers

    What percentage of lamotrigine is protein-bound?

    <p>55%</p> Signup and view all the answers

    When prescribing lamotrigine, what is warranted?

    <p>Consultation with a neurologist</p> Signup and view all the answers

    Which of the following should NOT be monitored when a patient is taking lamotrigine?

    <p>Cardiovascular health</p> Signup and view all the answers

    How should patients take lamotrigine tablets?

    <p>Take them exactly as prescribed without crushing or chewing</p> Signup and view all the answers

    What should patients do if they develop a rash while taking lamotrigine?

    <p>Report it to their provider immediately</p> Signup and view all the answers

    Which of the following potential adverse drug reactions (ADRs) should patients and their families be warned about when taking lamotrigine?

    <p>Neuropsychiatric reactions, including suicidal thoughts and behavioral changes</p> Signup and view all the answers

    What lifestyle management strategies are recommended for patients with seizures who are taking lamotrigine?

    <p>Get adequate sleep and exercise, avoid stressful situations</p> Signup and view all the answers

    What is a concerning potential side effect associated with lamotrigine use?

    <p>Increased suicidal thoughts</p> Signup and view all the answers

    How should lamotrigine be tapered off to avoid withdrawal seizures?

    <p>Tapered off over 2 weeks</p> Signup and view all the answers

    Which of the following is a rare reaction associated with lamotrigine?

    <p>Aplastic anemia</p> Signup and view all the answers

    What is the most concerning drug interaction with lamotrigine?

    <p>Increased risk of life-threatening rash when taken with valproate</p> Signup and view all the answers

    How does lamotrigine interact with oral estrogen-containing contraceptives?

    <p>Decreases lamotrigine levels by approximately 50%</p> Signup and view all the answers

    What is the initial dosing for patients aged 12 years and older who are not taking enzyme-inducing antiepileptic drugs (AEDs)?

    <p>$25 mg per day for 2 weeks</p> Signup and view all the answers

    What does the concurrent administration of valproate with lamotrigine increase the risk of?

    <p>$200% increase in life-threatening rash development</p> Signup and view all the answers

    How is dosing adjusted for children aged 2 to 12 years who are not taking enzyme-inducing AEDs?

    <p>$0.3 mg/kg per day for weeks 1 and 2</p> Signup and view all the answers

    What should be avoided when prescribing regular or chewable tablets of lamotrigine?

    <p>$Crushing or chewing the tablets</p> Signup and view all the answers

    Which of the following statements regarding lamotrigine metabolism is correct?

    <p>It is metabolized via glucuronic acid conjugation in the liver.</p> Signup and view all the answers

    Which of the following is a contraindication for lamotrigine?

    <p>Hypersensitivity to the drug or its ingredients</p> Signup and view all the answers

    Which of the following is a potential life-threatening adverse reaction associated with lamotrigine?

    <p>Disseminated intravascular coagulation</p> Signup and view all the answers

    Which of the following statements regarding lamotrigine and rash is incorrect?

    <p>Pediatric patients are less likely to have serious rashes than adults.</p> Signup and view all the answers

    Which of the following is a potential risk associated with lamotrigine use?

    <p>Suicidal thoughts and depression</p> Signup and view all the answers

    Which of the following statements regarding lamotrigine withdrawal is correct?

    <p>Lamotrigine should be withdrawn slowly over at least 2 weeks.</p> Signup and view all the answers

    Which of the following statements regarding lamotrigine and pregnancy is correct?

    <p>Lamotrigine decreased folate levels in animal studies.</p> Signup and view all the answers

    Which of the following statements regarding lamotrigine and breastfeeding is incorrect?

    <p>Maternal lamotrigine levels remain constant during the postpartum period.</p> Signup and view all the answers

    For which of the following conditions is lamotrigine FDA approved for use in children aged 2 years and older?

    <p>Lennox-Gastaut syndrome</p> Signup and view all the answers

    Which of the following adverse reactions has a Black Box Warning associated with lamotrigine use?

    <p>Stevens-Johnson syndrome (SJS)</p> Signup and view all the answers

    What is the usual maintenance dose of lamotrigine for pediatric patients aged 2 to 12 years who are not taking valproate?

    <p>1 to 5 mg/kg per day</p> Signup and view all the answers

    What is the initial dose of lamotrigine in patients older than age 12 years who are taking valproate?

    <p>25 mg per day</p> Signup and view all the answers

    How should the dose of lamotrigine be adjusted in children who weigh less than 30 kg?

    <p>Increased by as much as 50%</p> Signup and view all the answers

    What is the dosage adjustment for lamotrigine in adult patients with bipolar disorder who are taking carbamazepine?

    <p>50 mg daily in weeks 3 and 4</p> Signup and view all the answers

    In patients taking oral contraceptives along with lamotrigine, how is the lamotrigine dose altered?

    <p>Increased by 50% weekly</p> Signup and view all the answers

    What is the dose of lamotrigine for pediatric patients aged 2 to 12 years taking valproate?

    <p>25 mg every other day for weeks 1 and 2</p> Signup and view all the answers

    What should be noted about the escalation schedule of lamotrigine in patients taking valproate?

    <p>.It involves a slower escalation due to decreased clearance</p> Signup and view all the answers

    More Like This

    Use Quizgecko on...
    Browser
    Open
    Browser
    Browser