32 Questions
What is the cornerstone in all aspects of chemical safety?
Toxicology
According to toxicology, what is the key theme related to the dose and the poison?
Dose–response relationship
What are toxins and where do they originate from?
Poisons originating from plants, microbial organisms, and venoms released by animals
What term is used for the unintended effects of prescription drugs?
Side effects
What drug was originally developed to reduce blood pressure but gained approval for treating erectile dysfunction?
Sildenafil
Apart from therapeutic effects, what are all other responses to prescription drugs referred to as?
Side effects
Which term is used to describe the toxic effects of a chemical that can develop rapidly after a single exposure, such as hydrogen cyanide or nerve gases?
Immediate toxicity
What is the term used to describe the toxic effects of chemicals that may take months or years to be recognized?
Delayed toxicity
Which type of toxic response is largely dependent on the ability of an injured tissue to adapt, repair, and regenerate?
Reversible toxic effect
In toxicology, what term is used to characterize the proximity between the site of chemical exposure and the site(s) of molecular action?
Local toxicity
What term is used to define an allergic reaction or sensitization reaction when a prior exposure to a chemical is required to produce its subsequent toxic effect?
Hypersensitivity
What term is used to describe the toxic effects of chemicals that are reversible depending on the ability of an injured tissue to adapt, repair, and regenerate?
Reversible toxic effect
In response to a previous exposure to a chemical or a structurally similar one, what kind of reaction can occur due to the immune system's adverse response?
Allergic reactions
What can be observed for chemicals like hydrogen cyanide or nerve gases, leading to rapid effects on the cardiovascular, respiratory, and neurological systems culminating in death within minutes?
Immediate toxicity
For tissues such as the liver and gastrointestinal tract that have a high ability to regenerate, many injuries are:
Reversible
What type of damage is largely irreversible due to the CNS's limited ability to divide and replace damaged neurons?
Irreversible toxic effect
What is the definition of drug addiction according to the text?
Loss of behavioral control over drug-seeking and drug-taking
Which type of drug use is associated with causing widespread adaptive changes in the brain, as mentioned in the text?
Drug abuse or harmful use
What is the primary goal of current neurobiological research on addiction, as mentioned in the text?
To understand the neuropharmacological and neuroadaptive mechanisms within specific neurocircuits
According to the WHO, what is the definition of drug misuse?
Taking more than the recommended dose or mistakenly taking the wrong medication
What is the state characterized by repeated, periodic, or continuous administration of a drug resulting in harm to the individual?
Drug dependence
Which type of drug use is defined as occasional, controlled, or social use, based on the text?
Occasional, controlled or social use
Which drug class primarily acts through activation of the sympathetic nervous system?
Stimulants
What is one of the most frequent examples of natural stimulants mentioned in the text?
Khat
Which drug is associated with symptoms such as altered mental status, life-threatening situations like coma, and seizures?
Opioids
What is a serious medical complication arising from drug abuse that manifests during abstinence from the drug?
Withdrawal syndrome
What are the cardiovascular manifestations of drug abuse mentioned in the text?
Arrhythmias and organ ischemia
Which drug class may be correlated with the incidence of crime and is mentioned to accompany psychological dependence?
Stimulants
What is a key element of drug addiction mentioned in the text?
Neurobiological bases for acute drug reward
What type of symptoms can range from headaches and altered mental status to life-threatening situations like coma and seizures due to drug abuse?
Central nervous system symptoms
What type of illness may accompany psychological dependence on certain drugs according to the text?
Physical illness
What may occur due to misuse of drugs, such as alterations in body temperature, electrolytes, and acid–base disturbances?
Metabolic effects
Explore the significance of toxicology as the study of adverse effects of chemicals, biological, or physical agents on living organisms and the environment. Learn about the dose-response relationship and its pivotal role in toxicology.
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