Introduction to Toxicology Importance

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32 Questions

What is the cornerstone in all aspects of chemical safety?

Toxicology

According to toxicology, what is the key theme related to the dose and the poison?

Dose–response relationship

What are toxins and where do they originate from?

Poisons originating from plants, microbial organisms, and venoms released by animals

What term is used for the unintended effects of prescription drugs?

Side effects

What drug was originally developed to reduce blood pressure but gained approval for treating erectile dysfunction?

Sildenafil

Apart from therapeutic effects, what are all other responses to prescription drugs referred to as?

Side effects

Which term is used to describe the toxic effects of a chemical that can develop rapidly after a single exposure, such as hydrogen cyanide or nerve gases?

Immediate toxicity

What is the term used to describe the toxic effects of chemicals that may take months or years to be recognized?

Delayed toxicity

Which type of toxic response is largely dependent on the ability of an injured tissue to adapt, repair, and regenerate?

Reversible toxic effect

In toxicology, what term is used to characterize the proximity between the site of chemical exposure and the site(s) of molecular action?

Local toxicity

What term is used to define an allergic reaction or sensitization reaction when a prior exposure to a chemical is required to produce its subsequent toxic effect?

Hypersensitivity

What term is used to describe the toxic effects of chemicals that are reversible depending on the ability of an injured tissue to adapt, repair, and regenerate?

Reversible toxic effect

In response to a previous exposure to a chemical or a structurally similar one, what kind of reaction can occur due to the immune system's adverse response?

Allergic reactions

What can be observed for chemicals like hydrogen cyanide or nerve gases, leading to rapid effects on the cardiovascular, respiratory, and neurological systems culminating in death within minutes?

Immediate toxicity

For tissues such as the liver and gastrointestinal tract that have a high ability to regenerate, many injuries are:

Reversible

What type of damage is largely irreversible due to the CNS's limited ability to divide and replace damaged neurons?

Irreversible toxic effect

What is the definition of drug addiction according to the text?

Loss of behavioral control over drug-seeking and drug-taking

Which type of drug use is associated with causing widespread adaptive changes in the brain, as mentioned in the text?

Drug abuse or harmful use

What is the primary goal of current neurobiological research on addiction, as mentioned in the text?

To understand the neuropharmacological and neuroadaptive mechanisms within specific neurocircuits

According to the WHO, what is the definition of drug misuse?

Taking more than the recommended dose or mistakenly taking the wrong medication

What is the state characterized by repeated, periodic, or continuous administration of a drug resulting in harm to the individual?

Drug dependence

Which type of drug use is defined as occasional, controlled, or social use, based on the text?

Occasional, controlled or social use

Which drug class primarily acts through activation of the sympathetic nervous system?

Stimulants

What is one of the most frequent examples of natural stimulants mentioned in the text?

Khat

Which drug is associated with symptoms such as altered mental status, life-threatening situations like coma, and seizures?

Opioids

What is a serious medical complication arising from drug abuse that manifests during abstinence from the drug?

Withdrawal syndrome

What are the cardiovascular manifestations of drug abuse mentioned in the text?

Arrhythmias and organ ischemia

Which drug class may be correlated with the incidence of crime and is mentioned to accompany psychological dependence?

Stimulants

What is a key element of drug addiction mentioned in the text?

Neurobiological bases for acute drug reward

What type of symptoms can range from headaches and altered mental status to life-threatening situations like coma and seizures due to drug abuse?

Central nervous system symptoms

What type of illness may accompany psychological dependence on certain drugs according to the text?

Physical illness

What may occur due to misuse of drugs, such as alterations in body temperature, electrolytes, and acid–base disturbances?

Metabolic effects

Explore the significance of toxicology as the study of adverse effects of chemicals, biological, or physical agents on living organisms and the environment. Learn about the dose-response relationship and its pivotal role in toxicology.

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