Integumentary System and Immunology Quiz
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Questions and Answers

What role does the dermis play in the integumentary system?

  • It synthesizes vitamin D.
  • It plays a critical role in temperature regulation. (correct)
  • It forms the outermost layer of skin.
  • It provides sensory reception.
  • Which skin pigment is primarily responsible for skin color variation?

  • Chlorophyll
  • Melanin (correct)
  • Carotene
  • Hemoglobin
  • What type of tissue primarily composes the epidermis?

  • Nervous tissue
  • Muscle tissue
  • Epithelium (correct)
  • Connective tissue
  • What are the two layers of the dermis?

    <p>Papillary and reticular (B)</p> Signup and view all the answers

    Which function is not attributed to the skin?

    <p>Nutrient absorption (C)</p> Signup and view all the answers

    What is the primary type of connective tissue found in the dermis?

    <p>Dense irregular connective tissue (D)</p> Signup and view all the answers

    What is a characteristic of dermal papillae?

    <p>They create fingerprints and improve grip. (D)</p> Signup and view all the answers

    What is the primary function of neutrophils in the immune system?

    <p>To find, eat, and digest microbes (A)</p> Signup and view all the answers

    What do Toll-like receptors (TLRs) do in the immune system?

    <p>Bind to microbes and initiate an immune response (B)</p> Signup and view all the answers

    Which cells are derived from monocytes in the tissues?

    <p>Macrophages (A)</p> Signup and view all the answers

    What is a key function of natural killer (NK) cells?

    <p>Kill infected or cancerous cells (D)</p> Signup and view all the answers

    What role do cytokines play in the immune system?

    <p>They act as signaling molecules affecting cell behavior (A)</p> Signup and view all the answers

    Which structure is NOT considered a skin appendage?

    <p>Nerves (C)</p> Signup and view all the answers

    What is the primary composition of nails?

    <p>Hard keratin (A)</p> Signup and view all the answers

    Which type of hair is characterized as fine and short?

    <p>Vellus hair (D)</p> Signup and view all the answers

    What is the function of sebaceous glands?

    <p>Produce sebum for lubrication (B)</p> Signup and view all the answers

    Which statement about hair is accurate?

    <p>Hair grows at an average rate of 2 mm per week. (B)</p> Signup and view all the answers

    What structure is responsible for the sensation of light touch on the skin?

    <p>Hair (D)</p> Signup and view all the answers

    Which of the following is NOT a function of hair?

    <p>Lubrication (A)</p> Signup and view all the answers

    What is the term for the muscle associated with hair follicles that causes hair to stand up?

    <p>Arrector pili (A)</p> Signup and view all the answers

    Where are sweat glands NOT found?

    <p>Palms (D)</p> Signup and view all the answers

    Which type of sweat gland is most numerous and produces true sweat?

    <p>Eccrine glands (C)</p> Signup and view all the answers

    What is a characteristic of apocrine sweat glands?

    <p>They are found only in specific areas. (C)</p> Signup and view all the answers

    What defines a third-degree burn?

    <p>Full thickness, destroying epidermis and dermis. (B)</p> Signup and view all the answers

    What can be a consequence of severe burns?

    <p>Catastrophic loss of body fluids (C)</p> Signup and view all the answers

    Which method is commonly used to estimate burn surface area?

    <p>Rule of nines (C)</p> Signup and view all the answers

    Which type of burn includes redness without blisters?

    <p>First-degree burn (C)</p> Signup and view all the answers

    Where do ducts of apocrine glands open into?

    <p>Hair follicles (C)</p> Signup and view all the answers

    What effect does heat have on sweat glands?

    <p>Stimulates production (D)</p> Signup and view all the answers

    Which skin tumors are generally non-cancerous?

    <p>Benign tumors (D)</p> Signup and view all the answers

    What is a potential risk associated with infection from burns?

    <p>Sepsis and systemic infection (B)</p> Signup and view all the answers

    Which type of skin cancer is associated with the cells of the stratum basale?

    <p>Basal cell carcinoma (B)</p> Signup and view all the answers

    What characteristic of melanoma is indicated by 'A' in the mnemonic for its recognition?

    <p>Asymmetry (C)</p> Signup and view all the answers

    What type of immunity does NOT develop memory?

    <p>Innate immunity (A)</p> Signup and view all the answers

    Which of these cells is the most important for the innate immune response?

    <p>Neutrophils (B)</p> Signup and view all the answers

    Which component of the immune system serves as a physical barrier?

    <p>Mucous membranes (B)</p> Signup and view all the answers

    What is the primary function of the normal flora in the human body?

    <p>Competing with pathogens (A)</p> Signup and view all the answers

    Which of the following is a characteristic of acquired immunity?

    <p>Antigen specific (C)</p> Signup and view all the answers

    Which of the following is NOT a physical barrier in the immune system?

    <p>Blood cells (A)</p> Signup and view all the answers

    Which of these is primarily responsible for the humoral response within acquired immunity?

    <p>Antibodies (B)</p> Signup and view all the answers

    What are the characteristics of innate immunity?

    <p>No time lag and not antigen specific (B)</p> Signup and view all the answers

    Flashcards

    Epidermis

    The outer layer of skin, composed of epithelial tissue. It provides protection and is constantly renewed.

    Dermis

    The deeper, thicker layer of skin, composed of connective tissue. It provides strength, flexibility, and contains nerves and blood vessels.

    Skin Pigments

    The three types of pigments that contribute to skin color.

    Melanocytes

    Cells in the stratum basale that produce melanin. They transfer melanin granules to keratinocytes for protection from UV light.

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    Hypodermis

    The layer of tissue beneath the dermis, composed of adipose tissue. It helps insulate the body and anchor the skin.

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    Vitamin D Synthesis

    The process of synthesizing vitamin D in the skin through exposure to UV light.

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    Tension Lines

    The lines on the skin caused by the direction of collagen fibers in the dermis. They are important for surgeons to consider when making incisions.

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    Skin Appendages

    Specialized structures derived from the epidermis that extend into the dermis, including hair follicles, nails, sebaceous glands, and sweat glands.

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    Nails

    Hardened plates of keratin that cover the dorsal surface of the distal phalanges of the fingers and toes.

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    Hair Follicles

    Structures that produce hair, derived from both the epidermis and dermis.

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    Arrector Pili

    Smooth muscle associated with hair follicles that contracts to cause hair to stand on end, creating goosebumps.

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    Hair Bulb

    The base of a hair follicle containing epithelial cells surrounding a papilla of connective tissue. This is where hair growth begins.

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    Hair Papilla

    A structure within the hair bulb containing connective tissue that provides nutrients for hair growth.

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    Vellus Hair

    Small, fine hairs found throughout the body, except on palms and soles.

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    Sebaceous Glands

    Glands throughout the skin, except for palms and soles, that secrete sebum (oil) to lubricate and protect the skin.

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    Sweat Glands

    Glands that produce sweat, found throughout the skin, except for nipples and part of the external genitalia.

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    What is true sweat?

    Sweat produced by eccrine glands. Composed primarily of water, salts, and minor waste products.

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    Where are apocrine glands located?

    Apocrine sweat glands are found in specific regions like the armpit, groin, and anus. They secrete substances that decompose over time causing body odor.

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    What are ceruminous and mammary glands an example of?

    Sweat glands that are modified from apocrine glands.

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    What is the primary threat of burns?

    A condition that occurs when the body loses excessive fluids, leading to dehydration and potential circulatory shock.

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    What is a first-degree burn?

    A burn that affects only the epidermis, characterized by redness and pain.

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    What is a second-degree burn?

    A burn that affects the epidermis and part of the dermis, resulting in blisters.

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    What is a third-degree burn?

    A burn that damages the full thickness of the skin, affecting the epidermis, dermis, and sometimes the hypodermis.

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    What is the 'rule of 9's'?

    A method used to estimate the extent of burn injuries using the body's surface area.

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    What is a benign tumor?

    A tumor that is non-cancerous and does not spread to other areas of the body.

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    What is melanoma?

    A type of skin cancer that arises from melanin-producing cells.

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    Neutrophils

    A type of white blood cell (WBC) that patrols the blood, seeking out and engulfing microbes.

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    Monocytes

    A type of white blood cell (WBC) that migrates to tissues and transforms into macrophages. They play a key role in both innate and adaptive immunity.

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    Macrophages

    Highly effective phagocytic cells found in tissues, known for their ability to engulf and digest microbes. They also present antigens to lymphocytes, initiating an adaptive immune response.

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    Natural Killer (NK) cells

    A type of lymphocyte that does not require prior exposure to a microbe to act. They are crucial for the innate immune system, killing virus-infected and cancerous cells.

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    Toll-like receptors (TLRs)

    Transmembrane proteins found on macrophages and other immune cells. They act as sensors for microbes, triggering an immune response.

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    Actinic Keratosis

    A type of precancerous skin lesion, characterized by rough, scaly patches, often caused by prolonged sun exposure.

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    Basal Cell Carcinoma

    A type of skin cancer originating from cells in the stratum basale, the deepest layer of the epidermis. It's typically slow-growing and rarely spreads.

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    Squamous Cell Carcinoma

    A type of skin cancer that arises from keratinocytes in the epidermis. It's more aggressive than basal cell carcinoma and can spread if left untreated.

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    Melanoma

    The most serious form of skin cancer, originating from melanocytes, the pigment-producing cells. It's highly aggressive and can spread rapidly.

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    Immune system

    The body's defense system against disease and injury. It comprises two interconnected branches: nonspecific (innate) and specific (acquired) immunity.

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    Innate Immunity

    The first line of defense against pathogens, offering immediate but nonspecific protection. It involves physical barriers, antimicrobial substances, and cells like phagocytes.

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    Adaptive Immunity

    The second line of defense, offering a targeted and specific response tailored to each pathogen. It involves lymphocytes (T and B cells) and antibodies.

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    Complement System

    A mechanism that destroys pathogens by tagging them for destruction by other immune cells or causing their direct lysis. It's a key component of the innate immune system.

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    Cytokines

    Small protein messengers produced by immune cells that help coordinate the immune response, sending signals to other cells.

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    Phagocytes

    White blood cells that engulf and destroy foreign invaders like bacteria, viruses, and cellular debris. They are essential for innate immunity.

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    Study Notes

    Integumentary System

    • The integumentary system includes skin, hair, fingernails, and sweat and oil glands.
    • The skin protects the body, regulates body temperature, and excretes waste.
    • It's the first barrier to keep good things in (water) and bad things (bacteria) out.
    • The skin has two distinct regions: epidermis and dermis.

    Skin Functions

    • Protection
    • Synthesizes vitamin D with UV exposure
    • Homeostasis
    • Sensory reception (nerve endings)

    Epidermis Layers

    • Stratum corneum: Topmost layer; dead, flat cells filled with keratin; glycolipids make skin water resistant.
    • Stratum granulosum: Cells become flattened; organelles deteriorate; cytoplasm full of granules.
    • Stratum spinosum: Cells contain bundles of pre-keratin.
    • Stratum basale: Stem cells; actively dividing cells become part of superficial layers. Also contains melanocytes (melanin granules). Contains Merkel cells.
    • Thick vs. thin skin: Thick skin has an extra layer called stratum lucidum. The number of layers in the epidermis is the main difference between thick and thin skin.

    Dermis

    • Strong, flexible connective tissue, (fibroblasts, macrophages, mast cells, WBCs).
    • Rich supply of nerves and vessels.
    • Critical role in temperature regulation (the vessels).
    • Two layers:
      • Papillary: Areolar connective tissue; includes dermal papillae
      • Reticular: Network (reticulum) of collagen and reticular fibers

    Skin Appendages

    • Hair and hair follicles
    • Sebaceous (oil) glands
    • Sweat (sudoiferous) glands
    • Nails

    Hair

    • Function: Warmth (less in humans), sense light touch, protection (scalp).
    • Parts: Root (embedded in skin), shaft (projects above skin surface), consists of hard keratin, three concentric layers (medulla, cortex, cuticle).
    • Types: Vellus (fine, short), Intermediate, Terminal (longer, courser).
    • Growth: Averages 2 mm/week
    • Loss: Can be related to age (thinning), male pattern baldness.
    • Color: Determined by the amount of melanin.

    Sebaceous Glands

    • Produce sebum through holocrine secretion.
    • Oily secretion that lubricates and waterproofs skin.
    • Found everywhere on the body except palms and soles.

    Sweat Glands

    • Entire skin surface, except nipples and parts of external genitalia.
    • Prevent overheating (500 cc to 12 L/day; mostly water).
    • Humans are most efficient compared to other mammals.
    • Produced in response to stress and heat.
    • Two types: Eccrine (most numerous, open directly through pores) and Apocrine (open into hair follicles, with odor due to decomposition, and include mammary and ceruminous glands).

    Disorders of the Integumentary System

    • Burns: Threat to life due to catastrophic loss of fluids and body fluids leading to dehydration and shock, categorized as first-degree (redness), second-degree (blistering), third-degree (full thickness).
    • Infections: Direct contact or vector borne.
    • Wounds: Injuries requiring medical attention.
    • Skin cancer: Benign (warts), malignant (associated with UV exposure and skin aging, and involving cells of stratum basale (basal cell carcinoma), keratinocytes (squamous cell carcinoma), or melanocytes (melanoma)). Actinic keratosis = premalignant.

    Immune System

    • A functional system, NOT an organ system, that includes skin, lining of mucus membranes, secretions, blood cells, vasculature, bone marrow, liver, lymphatic system, and other lymphoid organs. Most tissues have resident immune cells.

    • Responds to disease and injury.

    • Two main types: Innate (non-specific) and Adaptive (specific).

    • Innate Immune System*

    • Internal Defenses:

      • Phagocytic cells
      • Antimicrobial proteins
      • Inflammatory response
      • Natural killer cells
      • Complement
    • Components of blood

      • Plasma, RBCs, WBCs, complement proteins, coagulation proteins, cytokines.
    • WBCs (White blood cells):

      • Neutrophils, Monocytes/macrophages, NK cells, and other components.
    • Components including:

      • Cytokines
      • Interferons (IFNs)
      • Interleukins
      • Tumour necrosis factor (TNF)
      • Complement
      • Coagulation proteins
      • Toll-like receptors (TLRs)
    • Phagocytosis: Key role of phagocytic cells (e.g., neutrophils, macrophages) in engulfing and destroying microbes.

      • stages of phagocytosis and role of lysozyme in digesting microbes
    • Adaptive Immune System*

    • (discussed independently).

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    Integumentary System - PDF

    Description

    Test your knowledge on the integumentary system, including the roles of the dermis, epidermis, and skin appendages. Explore key concepts related to the immune system, such as the function of neutrophils and cytokines. This quiz covers essential details that are crucial for understanding human anatomy and physiology.

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