Podcast
Questions and Answers
What role does the dermis play in the integumentary system?
What role does the dermis play in the integumentary system?
- It synthesizes vitamin D.
- It plays a critical role in temperature regulation. (correct)
- It forms the outermost layer of skin.
- It provides sensory reception.
Which skin pigment is primarily responsible for skin color variation?
Which skin pigment is primarily responsible for skin color variation?
- Chlorophyll
- Melanin (correct)
- Carotene
- Hemoglobin
What type of tissue primarily composes the epidermis?
What type of tissue primarily composes the epidermis?
- Nervous tissue
- Muscle tissue
- Epithelium (correct)
- Connective tissue
What are the two layers of the dermis?
What are the two layers of the dermis?
Which function is not attributed to the skin?
Which function is not attributed to the skin?
What is the primary type of connective tissue found in the dermis?
What is the primary type of connective tissue found in the dermis?
What is a characteristic of dermal papillae?
What is a characteristic of dermal papillae?
What is the primary function of neutrophils in the immune system?
What is the primary function of neutrophils in the immune system?
What do Toll-like receptors (TLRs) do in the immune system?
What do Toll-like receptors (TLRs) do in the immune system?
Which cells are derived from monocytes in the tissues?
Which cells are derived from monocytes in the tissues?
What is a key function of natural killer (NK) cells?
What is a key function of natural killer (NK) cells?
What role do cytokines play in the immune system?
What role do cytokines play in the immune system?
Which structure is NOT considered a skin appendage?
Which structure is NOT considered a skin appendage?
What is the primary composition of nails?
What is the primary composition of nails?
Which type of hair is characterized as fine and short?
Which type of hair is characterized as fine and short?
What is the function of sebaceous glands?
What is the function of sebaceous glands?
Which statement about hair is accurate?
Which statement about hair is accurate?
What structure is responsible for the sensation of light touch on the skin?
What structure is responsible for the sensation of light touch on the skin?
Which of the following is NOT a function of hair?
Which of the following is NOT a function of hair?
What is the term for the muscle associated with hair follicles that causes hair to stand up?
What is the term for the muscle associated with hair follicles that causes hair to stand up?
Where are sweat glands NOT found?
Where are sweat glands NOT found?
Which type of sweat gland is most numerous and produces true sweat?
Which type of sweat gland is most numerous and produces true sweat?
What is a characteristic of apocrine sweat glands?
What is a characteristic of apocrine sweat glands?
What defines a third-degree burn?
What defines a third-degree burn?
What can be a consequence of severe burns?
What can be a consequence of severe burns?
Which method is commonly used to estimate burn surface area?
Which method is commonly used to estimate burn surface area?
Which type of burn includes redness without blisters?
Which type of burn includes redness without blisters?
Where do ducts of apocrine glands open into?
Where do ducts of apocrine glands open into?
What effect does heat have on sweat glands?
What effect does heat have on sweat glands?
Which skin tumors are generally non-cancerous?
Which skin tumors are generally non-cancerous?
What is a potential risk associated with infection from burns?
What is a potential risk associated with infection from burns?
Which type of skin cancer is associated with the cells of the stratum basale?
Which type of skin cancer is associated with the cells of the stratum basale?
What characteristic of melanoma is indicated by 'A' in the mnemonic for its recognition?
What characteristic of melanoma is indicated by 'A' in the mnemonic for its recognition?
What type of immunity does NOT develop memory?
What type of immunity does NOT develop memory?
Which of these cells is the most important for the innate immune response?
Which of these cells is the most important for the innate immune response?
Which component of the immune system serves as a physical barrier?
Which component of the immune system serves as a physical barrier?
What is the primary function of the normal flora in the human body?
What is the primary function of the normal flora in the human body?
Which of the following is a characteristic of acquired immunity?
Which of the following is a characteristic of acquired immunity?
Which of the following is NOT a physical barrier in the immune system?
Which of the following is NOT a physical barrier in the immune system?
Which of these is primarily responsible for the humoral response within acquired immunity?
Which of these is primarily responsible for the humoral response within acquired immunity?
What are the characteristics of innate immunity?
What are the characteristics of innate immunity?
Flashcards
Epidermis
Epidermis
The outer layer of skin, composed of epithelial tissue. It provides protection and is constantly renewed.
Dermis
Dermis
The deeper, thicker layer of skin, composed of connective tissue. It provides strength, flexibility, and contains nerves and blood vessels.
Skin Pigments
Skin Pigments
The three types of pigments that contribute to skin color.
Melanocytes
Melanocytes
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Hypodermis
Hypodermis
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Vitamin D Synthesis
Vitamin D Synthesis
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Tension Lines
Tension Lines
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Skin Appendages
Skin Appendages
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Nails
Nails
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Hair Follicles
Hair Follicles
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Arrector Pili
Arrector Pili
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Hair Bulb
Hair Bulb
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Hair Papilla
Hair Papilla
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Vellus Hair
Vellus Hair
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Sebaceous Glands
Sebaceous Glands
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Sweat Glands
Sweat Glands
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What is true sweat?
What is true sweat?
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Where are apocrine glands located?
Where are apocrine glands located?
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What are ceruminous and mammary glands an example of?
What are ceruminous and mammary glands an example of?
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What is the primary threat of burns?
What is the primary threat of burns?
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What is a first-degree burn?
What is a first-degree burn?
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What is a second-degree burn?
What is a second-degree burn?
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What is a third-degree burn?
What is a third-degree burn?
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What is the 'rule of 9's'?
What is the 'rule of 9's'?
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What is a benign tumor?
What is a benign tumor?
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What is melanoma?
What is melanoma?
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Neutrophils
Neutrophils
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Monocytes
Monocytes
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Macrophages
Macrophages
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Natural Killer (NK) cells
Natural Killer (NK) cells
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Toll-like receptors (TLRs)
Toll-like receptors (TLRs)
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Actinic Keratosis
Actinic Keratosis
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Basal Cell Carcinoma
Basal Cell Carcinoma
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Squamous Cell Carcinoma
Squamous Cell Carcinoma
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Melanoma
Melanoma
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Immune system
Immune system
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Innate Immunity
Innate Immunity
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Adaptive Immunity
Adaptive Immunity
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Complement System
Complement System
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Cytokines
Cytokines
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Phagocytes
Phagocytes
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Study Notes
Integumentary System
- The integumentary system includes skin, hair, fingernails, and sweat and oil glands.
- The skin protects the body, regulates body temperature, and excretes waste.
- It's the first barrier to keep good things in (water) and bad things (bacteria) out.
- The skin has two distinct regions: epidermis and dermis.
Skin Functions
- Protection
- Synthesizes vitamin D with UV exposure
- Homeostasis
- Sensory reception (nerve endings)
Epidermis Layers
- Stratum corneum: Topmost layer; dead, flat cells filled with keratin; glycolipids make skin water resistant.
- Stratum granulosum: Cells become flattened; organelles deteriorate; cytoplasm full of granules.
- Stratum spinosum: Cells contain bundles of pre-keratin.
- Stratum basale: Stem cells; actively dividing cells become part of superficial layers. Also contains melanocytes (melanin granules). Contains Merkel cells.
- Thick vs. thin skin: Thick skin has an extra layer called stratum lucidum. The number of layers in the epidermis is the main difference between thick and thin skin.
Dermis
- Strong, flexible connective tissue, (fibroblasts, macrophages, mast cells, WBCs).
- Rich supply of nerves and vessels.
- Critical role in temperature regulation (the vessels).
- Two layers:
- Papillary: Areolar connective tissue; includes dermal papillae
- Reticular: Network (reticulum) of collagen and reticular fibers
Skin Appendages
- Hair and hair follicles
- Sebaceous (oil) glands
- Sweat (sudoiferous) glands
- Nails
Hair
- Function: Warmth (less in humans), sense light touch, protection (scalp).
- Parts: Root (embedded in skin), shaft (projects above skin surface), consists of hard keratin, three concentric layers (medulla, cortex, cuticle).
- Types: Vellus (fine, short), Intermediate, Terminal (longer, courser).
- Growth: Averages 2 mm/week
- Loss: Can be related to age (thinning), male pattern baldness.
- Color: Determined by the amount of melanin.
Sebaceous Glands
- Produce sebum through holocrine secretion.
- Oily secretion that lubricates and waterproofs skin.
- Found everywhere on the body except palms and soles.
Sweat Glands
- Entire skin surface, except nipples and parts of external genitalia.
- Prevent overheating (500 cc to 12 L/day; mostly water).
- Humans are most efficient compared to other mammals.
- Produced in response to stress and heat.
- Two types: Eccrine (most numerous, open directly through pores) and Apocrine (open into hair follicles, with odor due to decomposition, and include mammary and ceruminous glands).
Disorders of the Integumentary System
- Burns: Threat to life due to catastrophic loss of fluids and body fluids leading to dehydration and shock, categorized as first-degree (redness), second-degree (blistering), third-degree (full thickness).
- Infections: Direct contact or vector borne.
- Wounds: Injuries requiring medical attention.
- Skin cancer: Benign (warts), malignant (associated with UV exposure and skin aging, and involving cells of stratum basale (basal cell carcinoma), keratinocytes (squamous cell carcinoma), or melanocytes (melanoma)). Actinic keratosis = premalignant.
Immune System
-
A functional system, NOT an organ system, that includes skin, lining of mucus membranes, secretions, blood cells, vasculature, bone marrow, liver, lymphatic system, and other lymphoid organs. Most tissues have resident immune cells.
-
Responds to disease and injury.
-
Two main types: Innate (non-specific) and Adaptive (specific).
-
Innate Immune System*
-
Internal Defenses:
- Phagocytic cells
- Antimicrobial proteins
- Inflammatory response
- Natural killer cells
- Complement
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Components of blood
- Plasma, RBCs, WBCs, complement proteins, coagulation proteins, cytokines.
-
WBCs (White blood cells):
- Neutrophils, Monocytes/macrophages, NK cells, and other components.
-
Components including:
- Cytokines
- Interferons (IFNs)
- Interleukins
- Tumour necrosis factor (TNF)
- Complement
- Coagulation proteins
- Toll-like receptors (TLRs)
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Phagocytosis: Key role of phagocytic cells (e.g., neutrophils, macrophages) in engulfing and destroying microbes.
- stages of phagocytosis and role of lysozyme in digesting microbes
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Adaptive Immune System*
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(discussed independently).
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