Inhibitors of Cell Wall Synthesis III Quiz
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Questions and Answers

What is the primary mechanism of action of polymyxins?

  • Inhibition of DNA replication
  • Inhibition of cell wall synthesis
  • Inhibition of protein synthesis
  • Destabilization of the gram-negative cell membrane (correct)

    • Which of the following is NOT a component of the polymyxin B mixture?

  • B1
  • B6
  • B1-I
  • B4 (correct)

    • Which drug is a formulation containing polymyxin B?

  • Amoxicillin
  • Gentamicin
  • Vancomycin
  • Neosporin (correct)

    • Which route of administration is NOT suitable for polymyxins?

    <p>Oral</p> Signup and view all the answers

    Which of the following is a potential adverse effect of polymyxins?

    <p>All of the above</p> Signup and view all the answers

    Which polymyxin is used for parenteral administration as a drug of last resort for drug-resistant gram-negative infections?

    <p>Colistin (polymyxin E)</p> Signup and view all the answers

    What is the unique mechanism of action of daptomycin?

    <p>Calcium-dependent insertion into the membrane, leading to pore formation and depolarization</p> Signup and view all the answers

    Which of the following is a potential advantage of daptomycin?

    <p>Effective against resistant strains due to its unique mechanism of action</p> Signup and view all the answers

    Which type of bacteria are polymyxins primarily effective against?

    <p>Gram-negative bacteria</p> Signup and view all the answers

    Which of the following is a recommended administration route for polymyxins in the treatment of spinal meningitis?

    <p>Intrathecal</p> Signup and view all the answers

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