10 Questions
What is the primary mechanism of action of polymyxins?
Destabilization of the gram-negative cell membrane
Which of the following is NOT a component of the polymyxin B mixture?
B4
Which drug is a formulation containing polymyxin B?
Neosporin
Which route of administration is NOT suitable for polymyxins?
Oral
Which of the following is a potential adverse effect of polymyxins?
All of the above
Which polymyxin is used for parenteral administration as a drug of last resort for drug-resistant gram-negative infections?
Colistin (polymyxin E)
What is the unique mechanism of action of daptomycin?
Calcium-dependent insertion into the membrane, leading to pore formation and depolarization
Which of the following is a potential advantage of daptomycin?
Effective against resistant strains due to its unique mechanism of action
Which type of bacteria are polymyxins primarily effective against?
Gram-negative bacteria
Which of the following is a recommended administration route for polymyxins in the treatment of spinal meningitis?
Intrathecal
Test your knowledge on Beta-lactams and other cell wall/membrane agents with this quiz based on the pharmacology chapter 43 and chapter 50. Learn about the mechanisms of action, spectra, uses, and toxicities of different cell wall agents.
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