Lecture 8: Cytokines
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Questions and Answers

Which characteristic of cytokines is described as different cytokines having the same effect?

  • Antagonism
  • Synergy
  • Pleiotropism
  • Redundancy (correct)
  • What is the main function of TNF-alpha among the following?

  • Inhibit clotting
  • Suppress immune response
  • Reduce inflammation
  • Promote migration of innate cells (correct)
  • In the context of adaptive immune response, what is the role of fate-specifying cytokines secreted by antigen-presenting cells?

  • Activate B cells
  • Activate dendritic cells
  • Impact the differentiation of T cells (correct)
  • Promote antibody production
  • Which type of immunity is characterized by B cell activation and antibody production?

    <p>Humoral immunity</p> Signup and view all the answers

    What is the purpose of macrophage activation in local inflammation?

    <p>Clear pathogens at the site of infection</p> Signup and view all the answers

    Which cytokine is involved in therapies targeting Rheumatoid Arthritis and Chron's disease?

    <p>TNF-alpha</p> Signup and view all the answers

    What is the effect of TNF-alpha on blood vessels?

    <p>Dilates blood vessels</p> Signup and view all the answers

    Which type of immune response is mostly directed towards intracellular pathogens and viral infections?

    <p>Cell-mediated immunity</p> Signup and view all the answers

    What is the term used to describe two or more cytokines working together to induce an effect?

    <p>Synergy</p> Signup and view all the answers

    In the context of cytokines, what does pleiotropism refer to?

    <p>Cytokine may have effects on many cell types</p> Signup and view all the answers

    How do cytokines affect the producing cell?

    <p>By binding to receptors on the producing cell</p> Signup and view all the answers

    Which mechanism describes how cytokines affect adjacent cells?

    <p>Paracrine mechanism</p> Signup and view all the answers

    Which type of cytokines can move through circulation and bind to distant receptors?

    <p>All of the above</p> Signup and view all the answers

    What is the primary function of cytokines when they are produced due to an inducing stimulus?

    <p>Activation, proliferation, differentiation of target cells</p> Signup and view all the answers

    Which group does Interleukins belong to?

    <p>Interleukins</p> Signup and view all the answers

    What is the main consequence of having lots of TNF-alpha in the body?

    <p>Total body inflammation</p> Signup and view all the answers

    Which cytokines induce the synthesis and secretion of antimicrobial proteins like Mannose-binding lectin (MBL) and Complement components?

    <p>TNF-α and IL-6</p> Signup and view all the answers

    Which type of immune response does TNF-alpha stimulate by migrating dendritic cells to lymph nodes and inducing maturation?

    <p>Adaptive immune response</p> Signup and view all the answers

    What is the main role of c-reactive protein (CRP) in the acute phase response?

    <p>Opsonizing bacteria</p> Signup and view all the answers

    Which cytokines are responsible for causing fever by signaling to induce a cascade that leads to a signal to the hypothalamus?

    <p>IL-1b, IL-6, TNF-a</p> Signup and view all the answers

    In the acute phase response, which organ produces c-reactive protein (CRP) and Mannose-binding lectin (MBL)?

    <p>Liver</p> Signup and view all the answers

    How do inflammatory cytokines impact the bone marrow endothelium?

    <p>Inducing neutrophil mobilization</p> Signup and view all the answers

    Which cells secrete different cytokines that can impact differentiation of T cells?

    <p>Macrophages</p> Signup and view all the answers

    Which of the following best describes the role of cytokines in the body?

    <p>Exert effects through pleiotropy, synergy, antagonism</p> Signup and view all the answers

    What is the main outcome of having excessive TNF-alpha in the body leading to sepsis?

    <p>Sepsis: systemic infection and inflammation caused by blood clots</p> Signup and view all the answers

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