5 Questions
What distinguishes ulcerative colitis (UC) from Crohn disease (CD)?
UC is a mucosal inflammatory condition confined to the rectum and colon, while CD is a transmural inflammation of gastrointestinal mucosa that may occur in any part of the GI tract.
Which cytokine is increased in the mucosa and intestinal lumen of patients with both Crohn disease (CD) and ulcerative colitis (UC)?
Tumor necrosis factor-α (TNF-α)
What is a common factor that may trigger inflammation in genetically susceptible individuals with inflammatory bowel disease (IBD)?
Abnormal regulation of the innate immune response
What are antineutrophil cytoplasmic antibodies associated with in patients with inflammatory bowel disease (IBD)?
They are found in a high percentage of patients with UC and less frequently with CD.
What role does the microflora of the GI tract play in the development of inflammatory bowel disease (IBD)?
It provides an environmental trigger to activate inflammation in genetically susceptible individuals.
Test your knowledge of the etiology and pathophysiology of inflammatory bowel diseases such as ulcerative colitis and Crohn disease. Learn about the factors that cause IBD and the common pathogenic mechanism behind these conditions.
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