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WK 11: Introduction to Autoimmunity and Hypersensitivity

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30 Questions

What type of hypersensitivity reaction is associated with an immediate response?

Type I

Which autoimmune disease involves the immune system attacking the myelin sheath of nerve cells?

Multiple sclerosis

Which type of hypersensitivity reaction is characterized by immune complex deposition?

Type III

What type of antibody is involved in Type II hypersensitivity reactions?

IgG

Autoimmune hemolytic anemia is an example of which type of hypersensitivity reaction?

Type II

Which autoimmune disease involves antibodies attacking the acetylcholine receptors at the neuromuscular junction?

Myasthenia gravis

What is a hypersensitivity reaction?

An inappropriate immune response to a harmless substance.

What type of hypersensitivity reaction is an allergic reaction?

Type I hypersensitivity

What is an autoimmune disease?

A hypersensitivity reaction targeted at the body's own tissues.

What is an example of a Type A adverse reaction?

Morphine causing drowsiness.

What is anaphylaxis?

A severe allergic reaction with systemic features.

What is the difference between hypersensitivity and allergy?

Allergy is a specific type of hypersensitivity reaction.

What key immune components are involved in type III hypersensitivity reactions?

IgM and IgG antibodies

Which type of antibodies form immune complexes in type III hypersensitivity reactions?

IgG antibodies

Where do immune complexes deposit in type III hypersensitivity reactions?

Small blood vessels

What type of damage can immune complexes cause in type III hypersensitivity reactions?

Renal damage

Which disease is an example of a type III hypersensitivity reaction?

Systemic lupus erythematosus

What type of cells are involved in type IV hypersensitivity reactions?

T cells

What type of immune reaction is hypersensitivity reaction?

Type B

Which of the following is an example of a genetic variability causing oxidative crises?

G6PD deficiency

What key immune components are involved in Type I hypersensitivity reactions?

Mast cells

What is a common clinical feature associated with Type I hypersensitivity reactions?

Angioedema

In Type II hypersensitivity reactions, what consequences depend entirely upon the tissue targeted and antibody binding?

Signs of anemia

In organ transplant rejection, what plays a role similar to antibody-dependent cytotoxicity seen in Type II hypersensitivity reactions?

Complement activation

Which type of hypersensitivity reaction is characterized by IgE-mediated mast cell activation?

Type I

What is the key feature of type II hypersensitivity reactions?

IgG antibody-mediated destruction

Which disease results from the immune destruction of insulin-producing cells?

Type I diabetes mellitus

What is the primary outcome of immune damage to myelin sheaths around nerves in multiple sclerosis?

Focal neurological symptoms

Which hypersensitivity reaction is characterized by immune complex-mediated tissue damage?

Type III

In which type of hypersensitivity reaction is T-cell-mediated destruction of host cells a key mechanism?

Type IV

Explore definitions and examples of hypersensitivity and allergic reactions in immunology. Learn about inappropriate immune responses to environmental stimuli or host antigens. Understand the distinction between hypersensitivity reactions and allergic reactions.

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