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Questions and Answers
What is one consequence of transfusion reactions involving blood group mismatches?
What is one consequence of transfusion reactions involving blood group mismatches?
- Opsonization of mismatched donor cells by preformed antibodies (correct)
- Activation of the immune system without symptoms
- Production of antibodies against host blood
- Increased production of red blood cells
Which condition involves IgG anti-erythrocyte antibodies crossing the placenta?
Which condition involves IgG anti-erythrocyte antibodies crossing the placenta?
- Hemolytic disease of the fetus and newborn (correct)
- Agranulocytosis
- Transfusion reaction
- Drug-induced hemolysis
In autoimmune hemolytic anemia, what is primarily targeted by the antibodies produced by the individual?
In autoimmune hemolytic anemia, what is primarily targeted by the antibodies produced by the individual?
- Only white blood cells
- Foreign pathogens only
- Platelets only
- The individual's own blood cells (correct)
In drug-induced antibody-mediated destruction, how do drugs typically trigger an immune response?
In drug-induced antibody-mediated destruction, how do drugs typically trigger an immune response?
Which of the following is NOT a situation in which antibody-mediated destruction occurs?
Which of the following is NOT a situation in which antibody-mediated destruction occurs?
Flashcards
Antibody-mediated cell destruction
Antibody-mediated cell destruction
Antibodies target and destroy cells, often through phagocytosis.
Transfusion reactions
Transfusion reactions
Blood transfusion complications due to incompatible blood types.
Hemolytic disease of the newborn
Hemolytic disease of the newborn
Fetal red blood cells destroyed by maternal antibodies.
Autoimmune hemolytic anemia
Autoimmune hemolytic anemia
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Drug-induced destruction of blood cells
Drug-induced destruction of blood cells
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Study Notes
Antibody-Mediated Cell Destruction
- Antibody-mediated destruction of cells involves phagocytosis and cell destruction.
- Transfusion Reactions: Mismatched blood transfusions lead to pre-formed antibodies reacting with donor cells, opsonizing them for destruction.
- Hemolytic Disease of the Fetus and Newborn (Erythroblastosis Fetalis): Maternal IgG anti-erythrocyte antibodies cross the placenta, attacking fetal red blood cells due to maternal-fetal blood group incompatibility.
- Autoimmune Hemolytic Anemia, Agranulocytosis, and Thrombocytopenia: An individual's immune system produces antibodies targeting their own blood cells, causing their destruction.
- Drug Reactions: Certain drugs can trigger antibody-mediated destruction of blood cells in two main ways:
- Drug binding to host cell membrane proteins, creating antibody targets.
- Drug altering the shape of antigens, producing new antigenic surfaces attacked by the immune system.
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