10 Questions
Which of the following is an example of clonal anergy?
T cells in circulation and tissues becoming unresponsive to self antigens
Where does T cell central tolerance occur?
In the thymus on immature T cells
Where does B cell central tolerance occur?
In the bone marrow on immature B cells
Where does T cell peripheral tolerance occur?
In the lymph nodes and spleen on mature T cells
Where does B cell peripheral tolerance occur?
In the lymph nodes and spleen on mature B cells
Which process removes a light chain if it is not functional or self-reactive and synthesizes a new light chain?
Receptor editing
What is the role of antigen contact in B cell activation?
Stimulate B cell migration
Which pathway is used for processing conformational vs linear epitopes for B cell activation?
MHC Class II pathway
What is the main function of germinal centers?
Affinity maturation
What is the difference between T-independent and T-dependent B cell activation?
The involvement of T cells
Test your knowledge of immune tolerance mechanisms with this quiz! Learn about clonal anergy, clonal ignorance, and tolerance, and discover the sites where T and B cells undergo central and peripheral tolerance. Challenge yourself with questions that cover key concepts in immunology.
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