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Questions and Answers
What is the primary function of the gastric alkaline barrier?
What is the primary function of the gastric alkaline barrier?
What is the role of carbonic anhydrase in HCl production?
What is the role of carbonic anhydrase in HCl production?
What is the source of H+ ions that are transported to the lumen of the stomach?
What is the source of H+ ions that are transported to the lumen of the stomach?
What is the primary component of the gastric alkaline barrier?
What is the primary component of the gastric alkaline barrier?
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What is the effect of feeding on the gastric alkaline barrier?
What is the effect of feeding on the gastric alkaline barrier?
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What is the primary goal of digestion in the human body?
What is the primary goal of digestion in the human body?
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Which enzyme is responsible for breaking down polysaccharides into dextrins?
Which enzyme is responsible for breaking down polysaccharides into dextrins?
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What happens to digested food molecules after digestion?
What happens to digested food molecules after digestion?
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Which condition indicates a failure of absorption?
Which condition indicates a failure of absorption?
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What type of carbohydrates must be broken down further during digestion?
What type of carbohydrates must be broken down further during digestion?
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What is the main source of complex carbohydrates in the human diet?
What is the main source of complex carbohydrates in the human diet?
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What is the term for the movement of digested food molecules through the intestinal walls?
What is the term for the movement of digested food molecules through the intestinal walls?
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What role does salivary amylase play in the digestive process?
What role does salivary amylase play in the digestive process?
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Which of the following statements describes the difference between the Gastric Phase and the Intestinal Phase of gastric acid secretion?
Which of the following statements describes the difference between the Gastric Phase and the Intestinal Phase of gastric acid secretion?
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What is the primary role of the 'Reverse Enterogastric Reflex' in the context of gastric acid secretion?
What is the primary role of the 'Reverse Enterogastric Reflex' in the context of gastric acid secretion?
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Which of the following hormones is NOT involved in inhibiting gastric acid secretion?
Which of the following hormones is NOT involved in inhibiting gastric acid secretion?
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What is the primary role of enterokinase in protein digestion?
What is the primary role of enterokinase in protein digestion?
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What is the primary function of pancreatic amylase in carbohydrate digestion?
What is the primary function of pancreatic amylase in carbohydrate digestion?
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How does the secretion of bicarbonate ions (HCO3-) by pancreatic duct cells contribute to digestion?
How does the secretion of bicarbonate ions (HCO3-) by pancreatic duct cells contribute to digestion?
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Which of the following statements BEST describes the relationship between HCl production and the 'Reverse Enterogastric Reflex'?
Which of the following statements BEST describes the relationship between HCl production and the 'Reverse Enterogastric Reflex'?
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Which of the following scenarios would most likely activate the 'Reverse Enterogastric Reflex' and lead to a slowing down of gastric emptying?
Which of the following scenarios would most likely activate the 'Reverse Enterogastric Reflex' and lead to a slowing down of gastric emptying?
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Which of the following cells are responsible for producing histamine, which in turn stimulates parietal cells to produce HCl?
Which of the following cells are responsible for producing histamine, which in turn stimulates parietal cells to produce HCl?
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What is the function of 'Procarboxypeptidase', one of the pancreatic enzymes involved in protein digestion?
What is the function of 'Procarboxypeptidase', one of the pancreatic enzymes involved in protein digestion?
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Which of the following statements accurately describes the 'Interdigestive' or 'Fasting' period in gastric secretion?
Which of the following statements accurately describes the 'Interdigestive' or 'Fasting' period in gastric secretion?
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What is the significance of cellulose/fiber in the context of digestion?
What is the significance of cellulose/fiber in the context of digestion?
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Which of the following enzymes is primarily responsible for breaking down fats into fatty acids and monoglycerides?
Which of the following enzymes is primarily responsible for breaking down fats into fatty acids and monoglycerides?
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What is the primary role of 'Cholesterol esterase' in fat digestion?
What is the primary role of 'Cholesterol esterase' in fat digestion?
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Which of the following statements BEST describes the relationship between the exocrine and endocrine functions of the pancreas?
Which of the following statements BEST describes the relationship between the exocrine and endocrine functions of the pancreas?
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Which of the following stimuli would NOT likely trigger the release of pepsinogen and HCl in the stomach, even during the 'Interdigestive' period?
Which of the following stimuli would NOT likely trigger the release of pepsinogen and HCl in the stomach, even during the 'Interdigestive' period?
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What role do bile salts play in the small intestine?
What role do bile salts play in the small intestine?
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What is steatorrhea?
What is steatorrhea?
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How are short-chain fatty acids absorbed in the body?
How are short-chain fatty acids absorbed in the body?
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What occurs to long-chain fatty acids and monoglycerides once they enter enterocytes?
What occurs to long-chain fatty acids and monoglycerides once they enter enterocytes?
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What effect does the drug orlistat have on lipid digestion?
What effect does the drug orlistat have on lipid digestion?
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Where does the majority of lipid absorption take place in the digestive system?
Where does the majority of lipid absorption take place in the digestive system?
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How do bile salts aid in lipid absorption?
How do bile salts aid in lipid absorption?
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What is the primary cause of steatorrhea?
What is the primary cause of steatorrhea?
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What is the primary enzyme responsible for breaking down dextrins in the small intestine?
What is the primary enzyme responsible for breaking down dextrins in the small intestine?
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Which of the following products are formed from the digestion of sucrose?
Which of the following products are formed from the digestion of sucrose?
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Where does the action of salivary amylase occur?
Where does the action of salivary amylase occur?
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Which monosaccharides are produced from the digestion of lactose?
Which monosaccharides are produced from the digestion of lactose?
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What is the role of disaccharidases at the brush border of enterocytes?
What is the role of disaccharidases at the brush border of enterocytes?
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What happens to carbohydrates in the stomach?
What happens to carbohydrates in the stomach?
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What are the final products absorbed in the GI tract from carbohydrate digestion?
What are the final products absorbed in the GI tract from carbohydrate digestion?
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Which of the following enzymes is NOT a disaccharidase?
Which of the following enzymes is NOT a disaccharidase?
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What type of molecules are dextrins composed of?
What type of molecules are dextrins composed of?
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Which enzyme digests maltose into its monomer units?
Which enzyme digests maltose into its monomer units?
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How do chloride ions primarily enter the bloodstream in the upper part of the small intestine?
How do chloride ions primarily enter the bloodstream in the upper part of the small intestine?
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What role does bicarbonate play in the absorption of chloride in the large intestine?
What role does bicarbonate play in the absorption of chloride in the large intestine?
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Which ions are absorbed actively through the intestinal mucosa?
Which ions are absorbed actively through the intestinal mucosa?
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What determines the degree of iron absorption in the small intestine?
What determines the degree of iron absorption in the small intestine?
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What mechanism do chloride ions use to exit the cells in the basal side of the intestinal wall?
What mechanism do chloride ions use to exit the cells in the basal side of the intestinal wall?
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What happens to the electrical charge balance when chloride ions are absorbed?
What happens to the electrical charge balance when chloride ions are absorbed?
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Which transporter is involved in chloride absorption in the ileum?
Which transporter is involved in chloride absorption in the ileum?
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What is a characteristic of monovalent ions compared to bivalent ions in absorption?
What is a characteristic of monovalent ions compared to bivalent ions in absorption?
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Which ion absorption in the small intestine is predominantly active?
Which ion absorption in the small intestine is predominantly active?
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What is the primary method of chloride absorption in the upper part of the small intestine?
What is the primary method of chloride absorption in the upper part of the small intestine?
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Flashcards
HCl production process
HCl production process
The process by which H2O in parietal cells dissociates into H+ and OH-, with H+ transported to the stomach lumen.
Gastric alkaline barrier
Gastric alkaline barrier
A protective barrier formed by mucus and bicarbonate in the stomach, maintaining a less acidic environment for the epithelial cells.
pH of stomach lumen
pH of stomach lumen
The acidity level of the stomach, which is approximately 2.0 due to the presence of HCl.
Active transport of H+
Active transport of H+
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Hypokalemia
Hypokalemia
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Digestion
Digestion
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Absorption
Absorption
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Cellulose digestion in humans
Cellulose digestion in humans
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Polysaccharides
Polysaccharides
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Salivary amylase
Salivary amylase
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Monosaccharides
Monosaccharides
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Main source of complex carbohydrates
Main source of complex carbohydrates
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Dextrins
Dextrins
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Gastric Phase
Gastric Phase
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HCl Production
HCl Production
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Parietal Cells
Parietal Cells
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Peptic Cells
Peptic Cells
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Gastrin
Gastrin
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Enterogastric Reflex
Enterogastric Reflex
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Secretin
Secretin
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Glucose-dependent Insulinotropic Peptide (GIP)
Glucose-dependent Insulinotropic Peptide (GIP)
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Vasoactive Intestinal Polypeptide (VIP)
Vasoactive Intestinal Polypeptide (VIP)
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Somatostatin
Somatostatin
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Pancreatic Enzymes
Pancreatic Enzymes
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Amylase
Amylase
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Lipase
Lipase
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Active Enzymes
Active Enzymes
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Pancreatic Amylase
Pancreatic Amylase
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Disaccharidases
Disaccharidases
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Maltose
Maltose
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Sucrose
Sucrose
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Lactose
Lactose
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Brush Border
Brush Border
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Carbohydrate Digestion Sites
Carbohydrate Digestion Sites
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Enterocytes
Enterocytes
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Bile Salts
Bile Salts
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Micelles
Micelles
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Steatorrhea
Steatorrhea
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Short and Medium-Chain Fatty Acids
Short and Medium-Chain Fatty Acids
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Long-Chain Fatty Acids
Long-Chain Fatty Acids
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Lipase Inhibition
Lipase Inhibition
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Orlistat
Orlistat
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Chloride Ion Absorption
Chloride Ion Absorption
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Role of Parathyroid Hormone
Role of Parathyroid Hormone
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Cl–HCO3– Exchanger
Cl–HCO3– Exchanger
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Chloride Diffusion Mechanism
Chloride Diffusion Mechanism
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Bacterial Fermentation in Colon
Bacterial Fermentation in Colon
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Ion Charge Neutrality
Ion Charge Neutrality
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Calcium Absorption
Calcium Absorption
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Iron Absorption
Iron Absorption
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Potassium and Magnesium Absorption
Potassium and Magnesium Absorption
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Monovalent vs. Bivalent Ions
Monovalent vs. Bivalent Ions
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Study Notes
Gastrointestinal Secretions, Digestion & Absorption
- Gastrointestinal Secretions: Alimentary glands are primarily exocrine, with ducts releasing secretions into a space. Endocrine glands, in contrast, release hormones into the bloodstream. Different gland types exist, including mucous glands (goblet cells), specialized secretory cells (like in Crypts of Lieberkühn), deep tubular glands (e.g., oxyntic glands), and complex compound acinous glands (pancreas, liver, and salivary glands).
Saliva
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Saliva Secretion: Occurs in two stages: acinar (with isotonic plasma-like levels of ions and containing ptyalin and mucus) and salivary duct (with decreased tonicity due to ion transport).
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Salivary Glands: Varied in type and function, including parotid (mostly serous), sublingual (mixed), submandibular (mixed), and buccal (mucus only) glands.
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Stimuli for Secretion: Tactile stimuli (food touching the pharynx), chemical irritation, gut wall distension, and autonomic/hormonal stimulation.
Stomach
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Stomach Glands: The stomach contains glands, primarily oxyntic and pyloric, producing substances like mucus, HCl, intrinsic factor, and pepsinogen.
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Oxyntic Glands: Located in the body and fundus, primarily responsible for producing HCl through active transport, producing intrinsic factor, and secreting pepsinogen.
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Pyloric Glands: Located in the antrum, primarily secreting mucus and gastrin (a hormone).
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Gastric Secretion: Occurs in three stages: cephalic (brain signals), gastric (food in stomach/local), and intestinal (chyme in small intestine). The initial stages are major stimulators.
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HCl Production: Parietal cells release H+ ions through a proton pump, combining with Cl- to result in HCl.
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Gastric Alkaline Barrier: Mucus and bicarbonate protect the stomach lining from autodigestion.
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Protein Digestion: Pepsin begins protein digestion in the acidic stomach environment.
Pancreas
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Pancreatic Secretions: Exocrine glands producing various enzymes (e.g., amylase, trypsin, chymotrypsin, lipase, etc.) and bicarbonate/water. These enzymes break down carbohydrates, proteins, and fats.
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Pancreatic Duct/Ductules: Produce water and bicarbonate for neutralization.
Small Intestines
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Brunner's Glands: Mucous glands in the duodenum secrete alkaline mucus to protect the intestinal lining.
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Crypts of Lieberkühn: In the small intestines, these glands secrete digestive enzymes.
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Brush Border Enzymes: Digestive enzymes on the surface of small intestine cells, breaking down disaccharides and peptides.
Large Intestines
- Large Intestine Secretion: Mucus secretion is regulated locally by tactile stimulation and nervous reflexes.
Digestion & Absorption (General)
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Digestion: Breakdown of food into absorbable molecules via mechanical and chemical means.
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Absorption: Movement of digested food molecules from the GI tract into the bloodstream. This often involves transporters, which can be active or passive.
Carbohydrate Absorption
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Site of Digestion: Mouth (salivary amylase), and the duodenum (pancreatic amylase). Disaccharidases on the brush border finish carbohydrate digestion in the small intestine.
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Carbohydrate Absorption: Products of digestion (monosaccharides) are transported across the intestinal wall, primarily through SGLT1 (sodium-glucose transporter 1) and GLUT2 (glucose transporter 2). Glucose and galactose use SGLT1 while fructose enters via GLUT5.
Protein Digestion and Absorption
- Protein Digestion: Pepsin in the stomach initiates digestion. Pancreatic proteases break proteins into peptides (and some amino acids) . Brush border enzymes convert the peptides into amino acids, which are transported actively (or sometimes passively) into the cells lining the intestines.
Fat Digestion and Absorption
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Fat Digestion: Lingual lipase in the stomach begins fat digestion, but the major enzymes are pancreatic lipases. Bile salts aid by emulsifying fats and forming micelles. Micelles facilitate breakdown and absorption of fatty acids and glycerol.
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Fat Absorption: These fats are absorbed into the epithelial cells via passive and facilitated diffusion. These lipids are combined with proteins to become chylomicrons, which enter the lacteals and eventually the bloodstream.
Other
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Water Absorption: Absorption of water occurs in the small and large intestines, with large amounts occurring in the small intestine. Water follows the osmotic gradient created by substances like sodium.
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Ion Absorption: Ions like sodium, chloride, and bicarbonate are absorbed both transcellularly and paracellularly using channels and transporters.
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Description
This quiz explores crucial aspects of human digestion, including the gastric alkaline barrier, the role of enzymes, and nutrient absorption. Learn about the physiological functions that aid in breaking down food and the processes involved in nutrient transport. Test your knowledge on the digestive system's mechanisms and phases.