Human Digestion and Enzymatic Functions
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What is the primary function of the gastric alkaline barrier?

  • To transport K+ ions from the stomach cells into the lumen.
  • To increase the pH of the stomach lumen.
  • To transport H+ ions from the lumen into the stomach cells.
  • To neutralize the acidity of the stomach lumen. (correct)
  • What is the role of carbonic anhydrase in HCl production?

  • Carbonic anhydrase catalyzes the formation of carbonic acid from CO2 and water. (correct)
  • Carbonic anhydrase transports H+ ions from the cytoplasm to the lumen.
  • Carbonic anhydrase breaks down carbonic acid into H+ and OH- ions.
  • Carbonic anhydrase regulates the pH of the stomach lumen.
  • What is the source of H+ ions that are transported to the lumen of the stomach?

  • They are taken from the metabolism of the cell. (correct)
  • They are produced by the breakdown of carbonic acid.
  • They are transported from the blood.
  • They are produced by the decomposition of H2O.
  • What is the primary component of the gastric alkaline barrier?

    <p>Mucus (A)</p> Signup and view all the answers

    What is the effect of feeding on the gastric alkaline barrier?

    <p>It increases the secretion of mucus and HCO3–. (B)</p> Signup and view all the answers

    What is the primary goal of digestion in the human body?

    <p>To break down food into usable substances (C)</p> Signup and view all the answers

    Which enzyme is responsible for breaking down polysaccharides into dextrins?

    <p>Salivary amylase (A)</p> Signup and view all the answers

    What happens to digested food molecules after digestion?

    <p>They should reach the bloodstream (D)</p> Signup and view all the answers

    Which condition indicates a failure of absorption?

    <p>Digested food molecules do not reach the bloodstream (D)</p> Signup and view all the answers

    What type of carbohydrates must be broken down further during digestion?

    <p>Polysaccharides (B)</p> Signup and view all the answers

    What is the main source of complex carbohydrates in the human diet?

    <p>Starch (B)</p> Signup and view all the answers

    What is the term for the movement of digested food molecules through the intestinal walls?

    <p>Absorption (B)</p> Signup and view all the answers

    What role does salivary amylase play in the digestive process?

    <p>It initiates carbohydrate digestion (C)</p> Signup and view all the answers

    Which of the following statements describes the difference between the Gastric Phase and the Intestinal Phase of gastric acid secretion?

    <p>The Gastric Phase primarily involves chyme entering the stomach, while the Intestinal Phase involves chyme entering the small intestine. (B), The Gastric Phase is stimulated by local nervous reflexes and gastrin, while the Intestinal Phase is inhibited by secretin and other intestinal hormones. (D)</p> Signup and view all the answers

    What is the primary role of the 'Reverse Enterogastric Reflex' in the context of gastric acid secretion?

    <p>To slow down gastric emptying when the small intestine is full and/or irritated. (B)</p> Signup and view all the answers

    Which of the following hormones is NOT involved in inhibiting gastric acid secretion?

    <p>Gastrin (A)</p> Signup and view all the answers

    What is the primary role of enterokinase in protein digestion?

    <p>It activates the inactive enzyme trypsinogen into its active form, trypsin. (A)</p> Signup and view all the answers

    What is the primary function of pancreatic amylase in carbohydrate digestion?

    <p>Breaking down starch, glycogen, and other carbohydrates into disaccharides and trisaccharides. (C)</p> Signup and view all the answers

    How does the secretion of bicarbonate ions (HCO3-) by pancreatic duct cells contribute to digestion?

    <p>They neutralize the acidic chyme entering the duodenum from the stomach. (B)</p> Signup and view all the answers

    Which of the following statements BEST describes the relationship between HCl production and the 'Reverse Enterogastric Reflex'?

    <p>Increased HCl production triggers the 'Reverse Enterogastric Reflex' to slow down gastric emptying. (B)</p> Signup and view all the answers

    Which of the following scenarios would most likely activate the 'Reverse Enterogastric Reflex' and lead to a slowing down of gastric emptying?

    <p>The arrival of acidic chyme into the duodenum, irritating the intestinal lining. (A)</p> Signup and view all the answers

    Which of the following cells are responsible for producing histamine, which in turn stimulates parietal cells to produce HCl?

    <p>Enterochromaffin-like (ECL) cells (C)</p> Signup and view all the answers

    What is the function of 'Procarboxypeptidase', one of the pancreatic enzymes involved in protein digestion?

    <p>It splits peptides into individual amino acids. (B)</p> Signup and view all the answers

    Which of the following statements accurately describes the 'Interdigestive' or 'Fasting' period in gastric secretion?

    <p>Gastric secretion is primarily limited to mucus, with minimal pepsinogen and almost no acid. (D)</p> Signup and view all the answers

    What is the significance of cellulose/fiber in the context of digestion?

    <p>It acts as a prebiotic in the colon, promoting the growth of beneficial bacteria. (B)</p> Signup and view all the answers

    Which of the following enzymes is primarily responsible for breaking down fats into fatty acids and monoglycerides?

    <p>Pancreatic lipase (A)</p> Signup and view all the answers

    What is the primary role of 'Cholesterol esterase' in fat digestion?

    <p>Hydrolyzing cholesterol esters into cholesterol and fatty acids. (D)</p> Signup and view all the answers

    Which of the following statements BEST describes the relationship between the exocrine and endocrine functions of the pancreas?

    <p>Both the exocrine and endocrine functions contribute to digestion, but the exocrine function is responsible for digestive enzyme secretion, while the endocrine function secretes hormones that regulate glucose metabolism. (A)</p> Signup and view all the answers

    Which of the following stimuli would NOT likely trigger the release of pepsinogen and HCl in the stomach, even during the 'Interdigestive' period?

    <p>The presence of acidic chyme in the duodenum (A)</p> Signup and view all the answers

    What role do bile salts play in the small intestine?

    <p>They transport lipids into enterocytes. (D)</p> Signup and view all the answers

    What is steatorrhea?

    <p>Excretion of undigested fats in stool. (D)</p> Signup and view all the answers

    How are short-chain fatty acids absorbed in the body?

    <p>They enter the blood circulation directly through capillaries. (D)</p> Signup and view all the answers

    What occurs to long-chain fatty acids and monoglycerides once they enter enterocytes?

    <p>They combine to form triglycerides. (B)</p> Signup and view all the answers

    What effect does the drug orlistat have on lipid digestion?

    <p>It inhibits lipase activity. (A)</p> Signup and view all the answers

    Where does the majority of lipid absorption take place in the digestive system?

    <p>In the duodenum. (D)</p> Signup and view all the answers

    How do bile salts aid in lipid absorption?

    <p>By forming micelles with lipids. (C)</p> Signup and view all the answers

    What is the primary cause of steatorrhea?

    <p>Inhibition of lipase activity. (C)</p> Signup and view all the answers

    What is the primary enzyme responsible for breaking down dextrins in the small intestine?

    <p>Pancreatic Amylase (B)</p> Signup and view all the answers

    Which of the following products are formed from the digestion of sucrose?

    <p>Glucose and Fructose (D)</p> Signup and view all the answers

    Where does the action of salivary amylase occur?

    <p>Buccal Cavity (D)</p> Signup and view all the answers

    Which monosaccharides are produced from the digestion of lactose?

    <p>Galactose and Glucose (B)</p> Signup and view all the answers

    What is the role of disaccharidases at the brush border of enterocytes?

    <p>Digest disaccharides into monosaccharides (D)</p> Signup and view all the answers

    What happens to carbohydrates in the stomach?

    <p>No carbohydrate digestion occurs (B)</p> Signup and view all the answers

    What are the final products absorbed in the GI tract from carbohydrate digestion?

    <p>Monosaccharides (B)</p> Signup and view all the answers

    Which of the following enzymes is NOT a disaccharidase?

    <p>Pancreatic Amylase (D)</p> Signup and view all the answers

    What type of molecules are dextrins composed of?

    <p>Polymers with 2-3 glucose molecules (D)</p> Signup and view all the answers

    Which enzyme digests maltose into its monomer units?

    <p>Maltase (B)</p> Signup and view all the answers

    How do chloride ions primarily enter the bloodstream in the upper part of the small intestine?

    <p>By diffusion along an electrical gradient (C)</p> Signup and view all the answers

    What role does bicarbonate play in the absorption of chloride in the large intestine?

    <p>It is secreted to maintain electrical neutrality (D)</p> Signup and view all the answers

    Which ions are absorbed actively through the intestinal mucosa?

    <p>Calcium, potassium, magnesium, and phosphate (D)</p> Signup and view all the answers

    What determines the degree of iron absorption in the small intestine?

    <p>The body's need for hemoglobin formation (A)</p> Signup and view all the answers

    What mechanism do chloride ions use to exit the cells in the basal side of the intestinal wall?

    <p>Diffusion through chloride channels (B)</p> Signup and view all the answers

    What happens to the electrical charge balance when chloride ions are absorbed?

    <p>A negative charge is lost requiring another negative charge to be brought in (D)</p> Signup and view all the answers

    Which transporter is involved in chloride absorption in the ileum?

    <p>Cl––HCO3– exchanger (A)</p> Signup and view all the answers

    What is a characteristic of monovalent ions compared to bivalent ions in absorption?

    <p>They are absorbed easily in great quantities (B)</p> Signup and view all the answers

    Which ion absorption in the small intestine is predominantly active?

    <p>Calcium (D)</p> Signup and view all the answers

    What is the primary method of chloride absorption in the upper part of the small intestine?

    <p>Secondary active transport with sodium ions (D)</p> Signup and view all the answers

    Flashcards

    HCl production process

    The process by which H2O in parietal cells dissociates into H+ and OH-, with H+ transported to the stomach lumen.

    Gastric alkaline barrier

    A protective barrier formed by mucus and bicarbonate in the stomach, maintaining a less acidic environment for the epithelial cells.

    pH of stomach lumen

    The acidity level of the stomach, which is approximately 2.0 due to the presence of HCl.

    Active transport of H+

    The process that moves H+ ions from parietal cells to the stomach lumen against the concentration gradient, making the stomach more acidic.

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    Hypokalemia

    A condition characterized by low potassium levels, which can be induced by the process of making the stomach more acidic.

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    Digestion

    The process of breaking down food into usable substances by mechanical and enzymatic action in the alimentary canal.

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    Absorption

    Movement of digested food molecules through the small intestine walls into the bloodstream for circulation.

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    Cellulose digestion in humans

    Humans lack enzymes to digest cellulose, making it indigestible food.

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    Polysaccharides

    Complex carbohydrates that need to be broken down into simpler forms like monosaccharides during digestion.

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    Salivary amylase

    An enzyme in saliva that begins breaking down polysaccharides into dextrins in the mouth.

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    Monosaccharides

    The simplest form of carbohydrates, which are the end products of polysaccharide breakdown.

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    Main source of complex carbohydrates

    Starch, which is found in foods like grains and potatoes, and is used for energy storage.

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    Dextrins

    Short chains of glucose produced during polysaccharide breakdown by enzymes like salivary amylase.

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    Gastric Phase

    Phase of digestion where HCl is predominantly produced after the food bolus enters the stomach.

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    HCl Production

    Mainly produced in the gastric phase, primarily by parietal cells.

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    Parietal Cells

    Cells in the stomach lining that secrete hydrochloric acid (HCl).

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    Peptic Cells

    Cells that secrete pepsinogen, an inactive enzyme for protein digestion.

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    Gastrin

    Hormone produced by G cells that stimulates HCl production in the stomach.

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    Enterogastric Reflex

    Reflex that inhibits gastric acid secretion as chyme enters the small intestine.

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    Secretin

    Hormone released by the small intestine that inhibits gastric acid secretion.

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    Glucose-dependent Insulinotropic Peptide (GIP)

    Hormone that inhibits gastric secretions and enhances insulin secretion.

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    Vasoactive Intestinal Polypeptide (VIP)

    Hormone that inhibits gastric acid production.

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    Somatostatin

    Hormone that inhibits growth hormone and gastric secretions.

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    Pancreatic Enzymes

    Enzymes secreted by the pancreas for digestion of proteins, fats, and carbohydrates.

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    Amylase

    Enzyme that hydrolyzes carbohydrates into disaccharides and trisaccharides.

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    Lipase

    Enzyme that breaks down fats into fatty acids and monoglycerides.

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    Active Enzymes

    Enzymes that are activated from their inactive forms (e.g., trypsin activating others).

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    Pancreatic Amylase

    Enzyme in the small intestine that breaks down disaccharides.

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    Disaccharidases

    Enzymes at the brush border that convert disaccharides into monosaccharides.

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    Maltose

    A disaccharide made of two glucose molecules.

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    Sucrose

    A disaccharide composed of fructose and glucose.

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    Lactose

    A disaccharide made of galactose and glucose.

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    Brush Border

    The microvilli of enterocytes where nutrient absorption occurs.

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    Carbohydrate Digestion Sites

    Locations where carbohydrate digestion occurs: buccal cavity, stomach, small intestine.

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    Enterocytes

    Cells lining the small intestine, involved in nutrient absorption.

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    Bile Salts

    Compounds that help emulsify fats for digestion in the small intestine.

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    Micelles

    Tiny lipid structures formed by bile salts that help absorb fats.

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    Steatorrhea

    The presence of excess fat in stool.

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    Short and Medium-Chain Fatty Acids

    Types of fatty acids absorbed directly into the bloodstream from enterocytes.

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    Long-Chain Fatty Acids

    Fatty acids that form inside enterocytes and require more processing.

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    Lipase Inhibition

    The reduction of lipase activity, affecting fat digestion.

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    Orlistat

    A drug that inhibits lipase to reduce fat absorption, leading to weight loss.

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    Chloride Ion Absorption

    Chloride ions are absorbed in the small intestine mainly by diffusion, following sodium ions' electrical gradient.

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    Role of Parathyroid Hormone

    Chloride absorption depends on the levels of parathyroid hormone and Vitamin D in the body.

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    Cl–HCO3– Exchanger

    In the ileum and large intestine, chloride is absorbed via the Cl–HCO3– exchanger in the brush border membrane.

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    Chloride Diffusion Mechanism

    Chloride diffuses into the blood through channels in the basolateral membrane after being absorbed in cells.

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    Bacterial Fermentation in Colon

    Bacteria in the large intestine produce acid from undigested particles, requiring bicarbonate to neutralize it.

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    Ion Charge Neutrality

    When chloride exits, bicarbonate is brought in to maintain electrical neutrality in the intestines.

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    Calcium Absorption

    Calcium is actively absorbed in the blood, with absorption influenced by parathyroid hormone and Vitamin D.

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    Iron Absorption

    Iron is actively absorbed in the small intestine, depending on hemoglobin production needs.

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    Potassium and Magnesium Absorption

    Potassium and magnesium are actively absorbed through the intestinal mucosa during digestion.

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    Monovalent vs. Bivalent Ions

    Monovalent ions are absorbed in large quantities, while bivalent ions are needed in smaller amounts.

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    Study Notes

    Gastrointestinal Secretions, Digestion & Absorption

    • Gastrointestinal Secretions: Alimentary glands are primarily exocrine, with ducts releasing secretions into a space. Endocrine glands, in contrast, release hormones into the bloodstream. Different gland types exist, including mucous glands (goblet cells), specialized secretory cells (like in Crypts of Lieberkühn), deep tubular glands (e.g., oxyntic glands), and complex compound acinous glands (pancreas, liver, and salivary glands).

    Saliva

    • Saliva Secretion: Occurs in two stages: acinar (with isotonic plasma-like levels of ions and containing ptyalin and mucus) and salivary duct (with decreased tonicity due to ion transport).

    • Salivary Glands: Varied in type and function, including parotid (mostly serous), sublingual (mixed), submandibular (mixed), and buccal (mucus only) glands.

    • Stimuli for Secretion: Tactile stimuli (food touching the pharynx), chemical irritation, gut wall distension, and autonomic/hormonal stimulation.

    Stomach

    • Stomach Glands: The stomach contains glands, primarily oxyntic and pyloric, producing substances like mucus, HCl, intrinsic factor, and pepsinogen.

    • Oxyntic Glands: Located in the body and fundus, primarily responsible for producing HCl through active transport, producing intrinsic factor, and secreting pepsinogen.

    • Pyloric Glands: Located in the antrum, primarily secreting mucus and gastrin (a hormone).

    • Gastric Secretion: Occurs in three stages: cephalic (brain signals), gastric (food in stomach/local), and intestinal (chyme in small intestine). The initial stages are major stimulators.

    • HCl Production: Parietal cells release H+ ions through a proton pump, combining with Cl- to result in HCl.

    • Gastric Alkaline Barrier: Mucus and bicarbonate protect the stomach lining from autodigestion.

    • Protein Digestion: Pepsin begins protein digestion in the acidic stomach environment.

    Pancreas

    • Pancreatic Secretions: Exocrine glands producing various enzymes (e.g., amylase, trypsin, chymotrypsin, lipase, etc.) and bicarbonate/water. These enzymes break down carbohydrates, proteins, and fats.

    • Pancreatic Duct/Ductules: Produce water and bicarbonate for neutralization.

    Small Intestines

    • Brunner's Glands: Mucous glands in the duodenum secrete alkaline mucus to protect the intestinal lining.

    • Crypts of Lieberkühn: In the small intestines, these glands secrete digestive enzymes.

    • Brush Border Enzymes: Digestive enzymes on the surface of small intestine cells, breaking down disaccharides and peptides.

    Large Intestines

    • Large Intestine Secretion: Mucus secretion is regulated locally by tactile stimulation and nervous reflexes.

    Digestion & Absorption (General)

    • Digestion: Breakdown of food into absorbable molecules via mechanical and chemical means.

    • Absorption: Movement of digested food molecules from the GI tract into the bloodstream. This often involves transporters, which can be active or passive.

    Carbohydrate Absorption

    • Site of Digestion: Mouth (salivary amylase), and the duodenum (pancreatic amylase). Disaccharidases on the brush border finish carbohydrate digestion in the small intestine.

    • Carbohydrate Absorption: Products of digestion (monosaccharides) are transported across the intestinal wall, primarily through SGLT1 (sodium-glucose transporter 1) and GLUT2 (glucose transporter 2). Glucose and galactose use SGLT1 while fructose enters via GLUT5.

    Protein Digestion and Absorption

    • Protein Digestion: Pepsin in the stomach initiates digestion. Pancreatic proteases break proteins into peptides (and some amino acids) . Brush border enzymes convert the peptides into amino acids, which are transported actively (or sometimes passively) into the cells lining the intestines.

    Fat Digestion and Absorption

    • Fat Digestion: Lingual lipase in the stomach begins fat digestion, but the major enzymes are pancreatic lipases. Bile salts aid by emulsifying fats and forming micelles. Micelles facilitate breakdown and absorption of fatty acids and glycerol.

    • Fat Absorption: These fats are absorbed into the epithelial cells via passive and facilitated diffusion. These lipids are combined with proteins to become chylomicrons, which enter the lacteals and eventually the bloodstream.

    Other

    • Water Absorption: Absorption of water occurs in the small and large intestines, with large amounts occurring in the small intestine. Water follows the osmotic gradient created by substances like sodium.

    • Ion Absorption: Ions like sodium, chloride, and bicarbonate are absorbed both transcellularly and paracellularly using channels and transporters.

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    Description

    This quiz explores crucial aspects of human digestion, including the gastric alkaline barrier, the role of enzymes, and nutrient absorption. Learn about the physiological functions that aid in breaking down food and the processes involved in nutrient transport. Test your knowledge on the digestive system's mechanisms and phases.

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