HSV Infection Diagnosis Methods
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Questions and Answers

What is the main characteristic feature of genital warts?

  • Presence of immature squamous cells with a perinuclear zone
  • Presence of goblet cells with a clear perinuclear zone
  • Presence of mature squamous cells with a clear perinuclear zone (correct)
  • Presence of basal cells with a clear cytoplasm

    • Which technique was initially used for HPV detection but was labor-intensive and time-consuming?

  • Hybrid capture HPV DNA Test (hc2)
  • Dot blot hybridization
  • Polymerase chain reaction
  • Southern blot hybridization (correct)

    • Which HPV detection technique can differentiate between 'low-risk' and 'high-risk' genotypes?

  • Dot blot hybridization
  • Polymerase chain reaction
  • Hybrid capture HPV DNA Test (hc2) (correct)
  • Pap smear

    • Which test can detect as little as 1 pg of HPV/ml?

    <p>Hybrid capture HPV DNA Test (hc2)</p> Signup and view all the answers

    Which technique selectively amplifies the HPV sequences present in biological specimens?

    <p>Polymerase chain reaction</p> Signup and view all the answers

    How is the Pap smear specimen collected for detection of viral infections like HPV and Herpes?

    <p>Vesicle swab collection</p> Signup and view all the answers

    Which technique is the most sensitive for detecting HSV DNA?

    <p>Polymerase chain reaction (PCR)</p> Signup and view all the answers

    What is the primary method for differentiating between HSV-1 and HSV-2?

    <p>Serologic assays based on glycoprotein G antigens</p> Signup and view all the answers

    Which of the following is true about the treatment of Herpes simplex?

    <p>Acyclovir prevents chain elongation by inhibiting viral DNA polymerase</p> Signup and view all the answers

    Which test can detect the presence of IgM or rising IgG titres for primary HSV infection?

    <p>Complement fixation test</p> Signup and view all the answers

    What is the diagnostic significance of giant cells or cow dry type A intranuclear inclusion bodies in a stained smear?

    <p>Diagnostic for Herpes simplex virus infection</p> Signup and view all the answers

    Which method is used to collect samples from vesicles for laboratory diagnosis of HSV?

    <p>Culture using swab from lesion base</p> Signup and view all the answers

    Which laboratory technique is commonly used to detect viral RNA in clinical specimens for HIV diagnosis?

    <p>Amplification assays</p> Signup and view all the answers

    What is the most widely used confirmation assay for HIV diagnosis that involves detecting antibodies to specific viral proteins?

    <p>Western blot technique</p> Signup and view all the answers

    Which viral proteins are most commonly assessed in the Western blot technique for HIV diagnosis?

    <p>p24 and envelope glycoproteins</p> Signup and view all the answers

    What does a decline in CD4+ cell count to less than 200 cells/μL correspond to in HIV/AIDS progression?

    <p>Increased risk of opportunistic infections</p> Signup and view all the answers

    Which technique is used to evaluate CD4+ T helper subset count for AIDS diagnosis?

    <p>Immunofluorescence with monoclonal anti-CD4 antibodies</p> Signup and view all the answers

    Which statement about the importance of viral load in HIV progression is accurate?

    <p>Lower viral load predicts disease progression</p> Signup and view all the answers

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