Podcast
Questions and Answers
What recent behavioral history may qualify an individual for HIV Pre-Exposure Prophylaxis (PrEP)?
What recent behavioral history may qualify an individual for HIV Pre-Exposure Prophylaxis (PrEP)?
- Consistent condom use with any partner
- Solely the use of non-injection recreational drugs
- Absence of any bacterial STI diagnosis in the past year
- Having had sex with a partner who is a known HIV carrier (correct)
Which condition is NOT mentioned as a consideration for evaluating eligibility for PrEP?
Which condition is NOT mentioned as a consideration for evaluating eligibility for PrEP?
- Injectable drug use
- Previous use of oral contraceptives (correct)
- History of one or more bacterial STIs in the last 6 months
- Inconsistent condom use
Which group is specifically highlighted concerning eligibility requirements for PrEP based on bacterial STI diagnoses?
Which group is specifically highlighted concerning eligibility requirements for PrEP based on bacterial STI diagnoses?
- Only heterosexual women
- Individuals in monogamous relationships
- Men who have sex with men (MSM) and transgender women (TGW) (correct)
- All genders equally
What is a significant reason individuals may hesitate to discuss their sexual history with healthcare providers regarding PrEP?
What is a significant reason individuals may hesitate to discuss their sexual history with healthcare providers regarding PrEP?
Which statement best describes the target group for HIV PrEP eligibility concerning drug use?
Which statement best describes the target group for HIV PrEP eligibility concerning drug use?
What is the initial dosing schedule for Intramuscular Cabotegravir?
What is the initial dosing schedule for Intramuscular Cabotegravir?
Which PrEP regimen requires a negative eCrCl of at least 30 mL/min?
Which PrEP regimen requires a negative eCrCl of at least 30 mL/min?
What is the recommended follow-up testing frequency for renal function in patients over 50 years?
What is the recommended follow-up testing frequency for renal function in patients over 50 years?
What additional screening is specifically recommended for MSM and TGW during routine follow-up?
What additional screening is specifically recommended for MSM and TGW during routine follow-up?
How often should patients receiving oral PrEP be tested for HIV?
How often should patients receiving oral PrEP be tested for HIV?
What is the maintenance dosing schedule for Cabotegravir after initial injections?
What is the maintenance dosing schedule for Cabotegravir after initial injections?
For which population is it preferred to administer IM Cabotegravir due to renal issues?
For which population is it preferred to administer IM Cabotegravir due to renal issues?
What is the critical screening that must be done within 1 week before initiating PrEP therapy?
What is the critical screening that must be done within 1 week before initiating PrEP therapy?
How often must STI screening occur for all sexually active patients on PrEP?
How often must STI screening occur for all sexually active patients on PrEP?
What is the optional oral lead-in period for starting Cabotegravir therapy?
What is the optional oral lead-in period for starting Cabotegravir therapy?
Which PrEP regimen can lead to severe renal impairment if not monitored properly?
Which PrEP regimen can lead to severe renal impairment if not monitored properly?
What specific health history should be taken into consideration when evaluating suitability for oral PrEP?
What specific health history should be taken into consideration when evaluating suitability for oral PrEP?
HIV testing should occur following the positive result during PrEP therapy for confirmation. What laboratory test should confirm the result?
HIV testing should occur following the positive result during PrEP therapy for confirmation. What laboratory test should confirm the result?
Which parameter is not part of the routine follow-up for patients on oral PrEP?
Which parameter is not part of the routine follow-up for patients on oral PrEP?
Flashcards
PrEP (Pre-Exposure Prophylaxis)
PrEP (Pre-Exposure Prophylaxis)
A medication taken by people who are HIV-negative to reduce their risk of getting infected with HIV.
HIV-positive Sexual Partner
HIV-positive Sexual Partner
A person who has a detectable or unknown viral load of HIV.
Inconsistent Condom Use
Inconsistent Condom Use
Not always using condoms during sex or not using condoms at all.
Bacterial STI
Bacterial STI
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MSM
MSM
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PrEP
PrEP
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Oral PrEP (Descovy)
Oral PrEP (Descovy)
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Intramuscular (IM) Cabotegravir (Apretude)
Intramuscular (IM) Cabotegravir (Apretude)
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PrEP Initiation Requirements
PrEP Initiation Requirements
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Baseline Screening for PrEP
Baseline Screening for PrEP
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Hepatitis Screening for PrEP
Hepatitis Screening for PrEP
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Renal Function Assessment for PrEP
Renal Function Assessment for PrEP
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Follow-up Testing During PrEP
Follow-up Testing During PrEP
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STI Screening during PrEP
STI Screening during PrEP
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PrEP Therapy Continuation
PrEP Therapy Continuation
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HIV Positive Test During PrEP
HIV Positive Test During PrEP
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IM Cabotegravir for Patients with Renal Disease
IM Cabotegravir for Patients with Renal Disease
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Lipid Monitoring for PrEP
Lipid Monitoring for PrEP
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PrEP Availability
PrEP Availability
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Study Notes
HIV Pre-Exposure Prophylaxis (PrEP)
- PrEP is a strategy to prevent HIV infection
- PrEP regimens include oral and intramuscular options
- Oral PrEP regimens:
- Emtricitabine (FTC) + Tenofovir alafenamide (TAF) (Descovy)
- Emtricitabine (FTC) + Tenofovir disoproxil fumarate (TDF) (Truvada)
- Dosing: once daily by mouth
- Intramuscular PrEP:
- Cabotegravir (CAB)
- Dosing: 600mg injection every 2 months
- Initial dosing: 2 injections, one month apart
- Oral lead-in option: 30mg cabotegravir daily for 28 days, then first injection
- Baseline screening and testing:
- Negative HIV test (Ag/Ab) within 1 week before initiation
- No signs/symptoms of acute HIV infection
- Hepatitis B and C serology
- Renal function tests
- STI screening (syphilis, gonorrhea, chlamydia)
- Specific tests depending on risk factors (e.g., MSM, transgender women, etc.)
- Follow-up testing:
- Oral PrEP: Every 3 months, assess for signs/symptoms of acute HIV, adherence and risk engagement behavior. MSM and TGW screen for sexually transmitted infections every 6 months. Every 12 months assessment of renal function, and assess for hepatitis C, chlamydia, syphilis in all patients
- IM PrEP: One month after first injection: HIV testing, signs of acute infection. Every 2 months (starting on month 3): HIV testing, signs of acute infection. Every 4 months (starting month 3): STI testing (MSM & TGW screen for syphilis, gonorrhea, and chlamydia. Heterosexual men & women screen for syphilis and gonorrhea. Every 12 months, after the first injection—discuss continuation of PrEP therapy assess for chlamydia.Â
- Eligibility criteria:
- Individuals at risk for HIV infection and who meet specific criteria, including sexual history and injection drug use
Abbreviations
- TAF: tenofovir alafenamide
- TDF: tenofovir disoproxil fumarate
- FTC: emtricitabine
- CAB: cabotegravir
- MSM: men who have sex with men
- TGW: transgender women
- PWID: people who inject drugs
- STI: sexually transmitted infection
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