HIV PrEP Overview and Testing Requirements

Choose a study mode

Play Quiz
Study Flashcards
Spaced Repetition
Chat to Lesson

Podcast

Play an AI-generated podcast conversation about this lesson

Questions and Answers

What recent behavioral history may qualify an individual for HIV Pre-Exposure Prophylaxis (PrEP)?

  • Consistent condom use with any partner
  • Solely the use of non-injection recreational drugs
  • Absence of any bacterial STI diagnosis in the past year
  • Having had sex with a partner who is a known HIV carrier (correct)

Which condition is NOT mentioned as a consideration for evaluating eligibility for PrEP?

  • Injectable drug use
  • Previous use of oral contraceptives (correct)
  • History of one or more bacterial STIs in the last 6 months
  • Inconsistent condom use

Which group is specifically highlighted concerning eligibility requirements for PrEP based on bacterial STI diagnoses?

  • Only heterosexual women
  • Individuals in monogamous relationships
  • Men who have sex with men (MSM) and transgender women (TGW) (correct)
  • All genders equally

What is a significant reason individuals may hesitate to discuss their sexual history with healthcare providers regarding PrEP?

<p>Fear of being judged based on their lifestyle (C)</p> Signup and view all the answers

Which statement best describes the target group for HIV PrEP eligibility concerning drug use?

<p>People who have used injectable drugs recreationally (A)</p> Signup and view all the answers

What is the initial dosing schedule for Intramuscular Cabotegravir?

<p>600 mg IM injection one month apart after two initial doses (B)</p> Signup and view all the answers

Which PrEP regimen requires a negative eCrCl of at least 30 mL/min?

<p>FTC + TAF (D)</p> Signup and view all the answers

What is the recommended follow-up testing frequency for renal function in patients over 50 years?

<p>Every 6 months (B)</p> Signup and view all the answers

What additional screening is specifically recommended for MSM and TGW during routine follow-up?

<p>Syphilis, gonorrhea, and chlamydia screening (A)</p> Signup and view all the answers

How often should patients receiving oral PrEP be tested for HIV?

<p>Every 3 months (C)</p> Signup and view all the answers

What is the maintenance dosing schedule for Cabotegravir after initial injections?

<p>600 mg every 2 months (D)</p> Signup and view all the answers

For which population is it preferred to administer IM Cabotegravir due to renal issues?

<p>Patients with significant renal disease (B)</p> Signup and view all the answers

What is the critical screening that must be done within 1 week before initiating PrEP therapy?

<p>HIV test (Ag/Ab) (A)</p> Signup and view all the answers

How often must STI screening occur for all sexually active patients on PrEP?

<p>Every 3 months (A)</p> Signup and view all the answers

What is the optional oral lead-in period for starting Cabotegravir therapy?

<p>28 days of oral doses (A)</p> Signup and view all the answers

Which PrEP regimen can lead to severe renal impairment if not monitored properly?

<p>FTC + TAF (B)</p> Signup and view all the answers

What specific health history should be taken into consideration when evaluating suitability for oral PrEP?

<p>Renal function and previous STI status (A)</p> Signup and view all the answers

HIV testing should occur following the positive result during PrEP therapy for confirmation. What laboratory test should confirm the result?

<p>Confirmatory laboratory testing for HIV (A)</p> Signup and view all the answers

Which parameter is not part of the routine follow-up for patients on oral PrEP?

<p>Vision tests (A)</p> Signup and view all the answers

Flashcards

PrEP (Pre-Exposure Prophylaxis)

A medication taken by people who are HIV-negative to reduce their risk of getting infected with HIV.

HIV-positive Sexual Partner

A person who has a detectable or unknown viral load of HIV.

Inconsistent Condom Use

Not always using condoms during sex or not using condoms at all.

Bacterial STI

A sexually transmitted infection (STI) such as syphilis, gonorrhea, or chlamydia.

Signup and view all the flashcards

MSM

Men who have sex with men.

Signup and view all the flashcards

PrEP

A medication regimen used to prevent HIV infection in people who are at risk.

Signup and view all the flashcards

Oral PrEP (Descovy)

A type of PrEP taken daily by mouth. It combines two antiretroviral drugs: emtricitabine (FTC) and tenofovir alafenamide (TAF).

Signup and view all the flashcards

Intramuscular (IM) Cabotegravir (Apretude)

A type of PrEP that involves injections of cabotegravir (CAB). It's administered by a healthcare provider every 2 months.

Signup and view all the flashcards

PrEP Initiation Requirements

A negative HIV test within a week before starting PrEP is required, along with no signs or symptoms of acute HIV infection.

Signup and view all the flashcards

Baseline Screening for PrEP

Before starting PrEP, a baseline assessment includes screening for STIs like syphilis, gonorrhea, and chlamydia, as well as hepatitis B and C for specific risk groups.

Signup and view all the flashcards

Hepatitis Screening for PrEP

Hepatitis B serology is mandatory for all individuals starting PrEP. Hepatitis C serology is recommended particularly for men who have sex with men (MSM), transgender women (TGW), and people who inject drugs (PWID).

Signup and view all the flashcards

Renal Function Assessment for PrEP

Renal function is assessed before starting PrEP, especially for people with existing kidney issues. Specific medications like emtricitabine (FTC) and tenofovir disoproxil fumarate (TDF) might not be suitable for individuals with reduced kidney function.

Signup and view all the flashcards

Follow-up Testing During PrEP

HIV tests (Ag/Ab and HIV-1 RNA assay) are conducted every 3 months during PrEP, along with assessing signs and symptoms of acute HIV infection, adherence to medication, and ongoing risk behaviors.

Signup and view all the flashcards

STI Screening during PrEP

For all sexually active individuals on PrEP, STI screening is recommended at least every 3 months. Specific screenings for syphilis, gonorrhea, and chlamydia are tailored based on sexual orientation and risk factors.

Signup and view all the flashcards

PrEP Therapy Continuation

Discussions about continuing or stopping PrEP therapy are held regularly during follow-up appointments. This helps to assess the patient's ongoing risk factors and the need for PrEP.

Signup and view all the flashcards

HIV Positive Test During PrEP

If a patient on PrEP tests positive for HIV, the results should be confirmed with appropriate laboratory testing.

Signup and view all the flashcards

IM Cabotegravir for Patients with Renal Disease

Intramuscular (IM) cabotegravir (Apretude) may be more suitable for patients with significant kidney disease who have adherence issues with daily oral PrEP regimes.

Signup and view all the flashcards

Lipid Monitoring for PrEP

For patients on emtricitabine (FTC) and tenofovir alafenamide (TAF), weight, triglyceride, and cholesterol levels should be assessed regularly.

Signup and view all the flashcards

PrEP Availability

PrEP therapy should be offered to patients when requested, even if no risk behavior is identified.

Signup and view all the flashcards

Study Notes

HIV Pre-Exposure Prophylaxis (PrEP)

  • PrEP is a strategy to prevent HIV infection
  • PrEP regimens include oral and intramuscular options
  • Oral PrEP regimens:
    • Emtricitabine (FTC) + Tenofovir alafenamide (TAF) (Descovy)
    • Emtricitabine (FTC) + Tenofovir disoproxil fumarate (TDF) (Truvada)
    • Dosing: once daily by mouth
  • Intramuscular PrEP:
    • Cabotegravir (CAB)
    • Dosing: 600mg injection every 2 months
    • Initial dosing: 2 injections, one month apart
    • Oral lead-in option: 30mg cabotegravir daily for 28 days, then first injection
  • Baseline screening and testing:
    • Negative HIV test (Ag/Ab) within 1 week before initiation
    • No signs/symptoms of acute HIV infection
    • Hepatitis B and C serology
    • Renal function tests
    • STI screening (syphilis, gonorrhea, chlamydia)
      • Specific tests depending on risk factors (e.g., MSM, transgender women, etc.)
  • Follow-up testing:
    • Oral PrEP: Every 3 months, assess for signs/symptoms of acute HIV, adherence and risk engagement behavior. MSM and TGW screen for sexually transmitted infections every 6 months. Every 12 months assessment of renal function, and assess for hepatitis C, chlamydia, syphilis in all patients
    • IM PrEP: One month after first injection: HIV testing, signs of acute infection. Every 2 months (starting on month 3): HIV testing, signs of acute infection. Every 4 months (starting month 3): STI testing (MSM & TGW screen for syphilis, gonorrhea, and chlamydia. Heterosexual men & women screen for syphilis and gonorrhea. Every 12 months, after the first injection—discuss continuation of PrEP therapy assess for chlamydia. 
  • Eligibility criteria:
    • Individuals at risk for HIV infection and who meet specific criteria, including sexual history and injection drug use

Abbreviations

  • TAF: tenofovir alafenamide
  • TDF: tenofovir disoproxil fumarate
  • FTC: emtricitabine
  • CAB: cabotegravir
  • MSM: men who have sex with men
  • TGW: transgender women
  • PWID: people who inject drugs
  • STI: sexually transmitted infection

Studying That Suits You

Use AI to generate personalized quizzes and flashcards to suit your learning preferences.

Quiz Team

Related Documents

HIV PrEP Chart PDF

More Like This

HIV Prevention and Transmission Quiz
3 questions
HIV Prevention Measures
3 questions

HIV Prevention Measures

LegendaryMajesty avatar
LegendaryMajesty
Southern African PrEP Guidelines 2020
45 questions
Use Quizgecko on...
Browser
Browser