Podcast
Questions and Answers
Which of the following regions is NOT involved in memory impairment when damaged?
Which of the following regions is NOT involved in memory impairment when damaged?
- Perirhinal cortex
- Hippocampus
- Motor cortex (correct)
- Parahippocampal cortex
Lesions in the hippocampus alone do not affect episodic memory.
Lesions in the hippocampus alone do not affect episodic memory.
False (B)
What does an episodic memory consist of?
What does an episodic memory consist of?
Stimulus and context
The hippocampus is crucial for storing _____ information, including when and where events occurred.
The hippocampus is crucial for storing _____ information, including when and where events occurred.
Match the type of lesion to its impact on memory:
Match the type of lesion to its impact on memory:
What happens to working memory with short delays?
What happens to working memory with short delays?
Context plays a significant role in forming episodic memories.
Context plays a significant role in forming episodic memories.
Which specific areas increase memory impairment when lesions occur?
Which specific areas increase memory impairment when lesions occur?
What is the primary function of the hippocampus in spatial navigation?
What is the primary function of the hippocampus in spatial navigation?
Lesioned rats can still utilize spatial cues effectively.
Lesioned rats can still utilize spatial cues effectively.
What is the name of the test used to assess the role of the hippocampus in spatial navigation?
What is the name of the test used to assess the role of the hippocampus in spatial navigation?
The hippocampus is responsible for encoding the '______' component of episodic memories.
The hippocampus is responsible for encoding the '______' component of episodic memories.
Match the following concepts with their descriptions:
Match the following concepts with their descriptions:
In the Morris water maze, what does it not matter when testing the rats?
In the Morris water maze, what does it not matter when testing the rats?
What percentage of convicted prisoners were mistakenly identified by an eyewitness and later exonerated according to the Innocence Project?
What percentage of convicted prisoners were mistakenly identified by an eyewitness and later exonerated according to the Innocence Project?
The function of the hippocampus during cue-based spatial navigation is well understood.
The function of the hippocampus during cue-based spatial navigation is well understood.
The misinformation effect involves incorporating accurate information into your memory of an event.
The misinformation effect involves incorporating accurate information into your memory of an event.
Describe a major limitation observed in rats with hippocampal lesions during the Morris water maze test.
Describe a major limitation observed in rats with hippocampal lesions during the Morris water maze test.
What can false identification during a line-up alter?
What can false identification during a line-up alter?
The __________ is a critical brain structure involved in memory and spatial navigation.
The __________ is a critical brain structure involved in memory and spatial navigation.
The phenomenon where misleading information is integrated into memory is known as the ________ effect.
The phenomenon where misleading information is integrated into memory is known as the ________ effect.
Match the following terms with their associated effects:
Match the following terms with their associated effects:
What is a consequence of not informing a witness that the perpetrator may not be in the line-up?
What is a consequence of not informing a witness that the perpetrator may not be in the line-up?
Match the following terms with their definitions:
Match the following terms with their definitions:
Who conducted a significant investigation into the malleability of memory in 2005?
Who conducted a significant investigation into the malleability of memory in 2005?
What is the primary role of the hippocampus in memory?
What is the primary role of the hippocampus in memory?
The hippocampus has no role in context-dependent memory.
The hippocampus has no role in context-dependent memory.
Which cells are recorded during navigation for their activity?
Which cells are recorded during navigation for their activity?
The process of memory being strengthened while sleeping is known as ______.
The process of memory being strengthened while sleeping is known as ______.
In what year did O'Keefe and Dostrovsky conduct their landmark study on hippocampal cells?
In what year did O'Keefe and Dostrovsky conduct their landmark study on hippocampal cells?
The 2014 Nobel Prize was awarded for research related to the hippocampus and spatial encoding.
The 2014 Nobel Prize was awarded for research related to the hippocampus and spatial encoding.
What type of memory is specifically linked with the medial temporal lobe?
What type of memory is specifically linked with the medial temporal lobe?
The study of the hippocampus includes exploring the difference between ______ and retrieval.
The study of the hippocampus includes exploring the difference between ______ and retrieval.
Which of the following is an ongoing area of research in relation to the hippocampus?
Which of the following is an ongoing area of research in relation to the hippocampus?
What is the primary purpose of the subsequent memory paradigm described in the study?
What is the primary purpose of the subsequent memory paradigm described in the study?
The encoding phase of the subsequent memory paradigm involves recalling a list of physical objects.
The encoding phase of the subsequent memory paradigm involves recalling a list of physical objects.
What does fMRI stand for?
What does fMRI stand for?
During retrieval, the brain activity at encoding is _____ in memory recall.
During retrieval, the brain activity at encoding is _____ in memory recall.
Match the words to their status during retrieval:
Match the words to their status during retrieval:
Which structure of the brain is primarily involved in the memory processes discussed?
Which structure of the brain is primarily involved in the memory processes discussed?
The study indicates that all words presented during encoding are equally likely to be remembered.
The study indicates that all words presented during encoding are equally likely to be remembered.
Name one of the two sources cited for the principles used in the study.
Name one of the two sources cited for the principles used in the study.
The quality check during retrieval determines whether a word is _____ or forgotten.
The quality check during retrieval determines whether a word is _____ or forgotten.
What is measured during the encoding phase according to the design?
What is measured during the encoding phase according to the design?
Flashcards
Delay Non-Match to Sample (DNMS)
Delay Non-Match to Sample (DNMS)
A task used to test episodic memory in animals. The animal learns to choose the novel, non-matching stimulus after a delay.
Hippocampus and DNMS performance
Hippocampus and DNMS performance
The more of the hippocampus that is damaged, the worse the animal performs on the DNMS task, especially when the delay is longer.
Input Regions of the Hippocampus
Input Regions of the Hippocampus
Regions like the perirhinal, parahippocampal, and entorhinal cortex connect to the hippocampus and play a role in processing information before it reaches the hippocampus.
Hippocampus and Episodic Memory
Hippocampus and Episodic Memory
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Episodic Memory Trace
Episodic Memory Trace
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Context and Episodic Memory
Context and Episodic Memory
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Hippocampus and Contextual Information
Hippocampus and Contextual Information
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Hippocampus and Episodic Memory Encoding
Hippocampus and Episodic Memory Encoding
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Memory Consolidation
Memory Consolidation
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Place Cells
Place Cells
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Episodic Memory
Episodic Memory
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Implicit Memory
Implicit Memory
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Memory Retrieval
Memory Retrieval
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Memory Encoding
Memory Encoding
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Familiarity
Familiarity
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Recall
Recall
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Hippocampus
Hippocampus
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Hippocampus & Spatial Navigation
Hippocampus & Spatial Navigation
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Hippocampus & Episodic Memory
Hippocampus & Episodic Memory
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Morris Water Maze
Morris Water Maze
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Hippocampal Lesion & Maze Performance
Hippocampal Lesion & Maze Performance
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Learning in the Morris Water Maze
Learning in the Morris Water Maze
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Hippocampal Lesion & Cue-Based Navigation
Hippocampal Lesion & Cue-Based Navigation
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Limitations of Lesion Studies
Limitations of Lesion Studies
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Morris Water Maze Experiment Significance
Morris Water Maze Experiment Significance
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Hippocampus: The Internal Map Maker
Hippocampus: The Internal Map Maker
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The Morris Water Maze: Exploring Spatial Navigation
The Morris Water Maze: Exploring Spatial Navigation
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Misinformation Effect
Misinformation Effect
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Suggestive Questions & Memory
Suggestive Questions & Memory
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Eyewitness Testimony & Reliability
Eyewitness Testimony & Reliability
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Misidentification in Wrongful Convictions
Misidentification in Wrongful Convictions
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Line-Up Instructions & False IDs
Line-Up Instructions & False IDs
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Innocence Project & Eyewitness Evidence
Innocence Project & Eyewitness Evidence
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Malleability of Memory
Malleability of Memory
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Subsequent Memory Paradigm
Subsequent Memory Paradigm
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Encoding
Encoding
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Retrieval
Retrieval
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Predictive Brain Activity
Predictive Brain Activity
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Input Regions
Input Regions
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Memory Quality
Memory Quality
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External Attention
External Attention
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Study Notes
Memory - Chapter 9, Part 1
- Cognitive Neuropsychology is the study of how the brain affects behaviour and the cognitive processes like memory.
- Memory's function is to predict what's going to happen next based on previous experiences.
- Key factors for memory evolution: danger, food, and partners.
Memory - Chapter 9, Part 2
- Memory function, also referred to as the memory's 'gist', is predicting the future after having previous experience.
- Generalisation: Applying past experience to similar experiences.
- Memory is like a Wikipedia page - information can be added or changed.
- Memory reconsolidation theory; following reactivation, memory traces return to a labile state.
Memory Stages
- Encoding: Acquisition and selection of information to be stored.
- Consolidation: Stabilizing the memory in the long-term memory.
- Storage: Permanent record of information.
- Retrieval: Accessing stored information.
- Reconsolidation: Retrieving stored information.
Amnesia Syndrome
- Anterograde amnesia: Loss of memory for events after a lesion or injury.
- Retrograde amnesia: Loss of memory for events before a lesion or injury.
- The Ribot Gradient (Temporal Gradient): a.k.a. Ribot's law; amnesia is more severe for recent memories.
- Patient H.M.: A famous case study of memory loss, resulting from surgery to treat epilepsy.
Patient H.M. - Deficits
- Anterograde amnesia (since lesion): Problems with encoding of new information .
- Retrograde amnesia (prior to lesion): Problems with recalling information before the lesion.
- Semantic memory (essentially frozen in 50s)
- Intact working memory: Can remember short sequences of numbers.
- Intact skill memory: Can improve on motor tasks, even without remembering training.
Memory Function: Diagram
- A diagram from slide 8 and 9 showing the structure and connections of different types of memories.
Hippocampal Place Cells
- Hippocampal cells fire at particular locations within a place.
- Helps in creating a 'map' of space.
- Used to encode where information occurred.
Memory Consolidation
- Process of transforming immediate memories into long-term memories.
- Takes a significant amount of time.
- Explains the different types of amnesias (retrograde and anterograde).
Theories of Consolidation
- Standard theory (Squire): Memories become independent of the hippocampus over time after being formed.
- Multiple Trace Theory (Moscovitch): Semantic context-free memories become independent of the hippocampus, but episodic memories always depend on the hippocampus.
Testing Reconsolidation
- ECT (Electroconvulsive Therapy) can disrupt memory.
- ECT only affects reactivated memories.
- ECT can be used to investigate memory reconsolidation.
- Different reactivation and test times.
- Different test groups (e.g. control group).
Eye Movement Desensitization and Reprocessing (EMDR) Therapy
- EMDR is used in the treatment of PTSD patients;
- Eye movements during extinction may cause amygdala deactivation.
- This is another alternative to test memory reconsolidation.
Memory Systems
- Declarative memory (Explicit memory)
- Episodic: Personal memories, with conscious awareness of time and place.
- Semantic: General knowledge of the world, without a particular time or place associated.
- Nondeclarative memory (Implicit memory):
- Procedural: Motor or cognitive skills.
- Perceptual priming: Recognizing things more easily after having seen them before.
- Classical conditioning; Learning a pairing of two stimuli.
- Non-associative learning; Learning a single stimulus.
The Medial Temporal Lobe
- Hippocampus, a key structure for long-term memory formation.
- The cortex around the hippocampus: helps in normal memory functions.
- Delayed non-match to sample tasks can be used to test the memory of non-human primates.
- Amygdala: Not critical for episodic memory but is important for emotional memory.
- Place cells in the hippocampus: Help in encoding contextual information.
Imaging
- Functional MRI: Shows that hippocampus is involved in encoding and retrieval of episodic memories and familiarity.
- The retrosplenial cortex: Crucial for many types of memory processes.
Misinformation Effect
- The misleading information can be incorporated into your memory of an event.
- This can have serious implications in real-life situations (e.g. legal disputes, recollection of traumatic events).
- Suggests the malleability of memory.
Which Brain Regions are Involved in Familiarity Memory?
- Perirhinal/anterior PHC is important for familiarity memory.
Retrieval
- Retrieval pathways: reactivation of areas that provided input initially.
- Sensory memory information retrieval; retrieving the perception associated with a stimulus/event.
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Description
Test your knowledge on the crucial role of the hippocampus in memory and spatial navigation. This quiz covers types of memory, the impact of lesions, and methods used to assess these functions. Challenge yourself with matching concepts and answering specific questions related to episodic memory.